Gemcitabine Delivery and Photodynamic Therapy in Cancer Cells via Porphyrin-Ethylene-Based Periodic Mesoporous Organosilica Nanoparticles

ChemNanoMat ◽  
2017 ◽  
Vol 4 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Dina Aggad ◽  
Chiara Mauriello Jimenez ◽  
Soraya Dib ◽  
Jonas G. Croissant ◽  
Laure Lichon ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica

Fluorescent periodic mesoporous organosilica nanoparticles dual-functionalized via click chemistry for two-photon photodynamic therapy in cells

2016 ◽  
Vol 4 (33) ◽  
pp. 5567-5574 ◽  
Author(s):  
Jonas G. Croissant ◽  
Sébastien Picard ◽  
Dina Aggad ◽  
Maxime Klausen ◽  
Chiara Mauriello Jimenez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Click Chemistry ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Periodic Mesoporous Organosilica ◽  
Two Photon ◽  
Mesoporous Organosilica ◽  
Photon Imaging ◽  
In Cells

The synthesis of ethenylene-based periodic mesoporous organosilica nanoparticles for two-photon imaging and photodynamic therapy of breast cancer cells is described.

scholarly journals The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics

2020 ◽  
Vol 8 (13) ◽  
pp. 3678-3684
Author(s):  
Morgane Daurat ◽  
Christophe Nguyen ◽  
Sofia Dominguez Gil ◽  
Vincent Sol ◽  
Vincent Chaleix ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Pulsed Laser ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica ◽  
Mannose 6 Phosphate

Periodic mesoporous organosilica nanoparticles targeted to the mannose 6-phosphate receptor for rhabdomyosarcoma photodynamic therapy using a pulsed laser.

scholarly journals Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells

2016 ◽  
Vol 22 (28) ◽  
pp. 9607-9615 ◽  
Author(s):  
Jonas G. Croissant ◽  
Yevhen Fatieiev ◽  
Haneen Omar ◽  
Dalaver H. Anjum ◽  
Andrey Gurinov ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Periodic Mesoporous Organosilica ◽  
High Drug ◽  
Mesoporous Organosilica

scholarly journals Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy

2021 ◽  
Vol 22 (5) ◽  
pp. 2251
Author(s):  
Fuyuhiko Tamanoi ◽  
Shanmugavel Chinnathambi ◽  
Mathilde Laird ◽  
Aoi Komatsu ◽  
Albane Birault ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Human Cancer ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Model ◽  
Periodic Mesoporous Organosilica ◽  
Human Cancer Cells ◽  
Mesoporous Organosilica ◽  
Tumor Accumulation

Biodegradable periodic mesoporous organosilica (BPMO) has recently emerged as a promising type of mesoporous silica-based nanoparticle for biomedical applications. Like mesoporous silica nanoparticles (MSN), BPMO possesses a large surface area where various compounds can be attached. In this work, we attached boronophenylalanine (10BPA) to the surface and explored the potential of this nanomaterial for delivering boron-10 for use in boron neutron capture therapy (BNCT). This cancer therapy is based on the principle that the exposure of boron-10 to thermal neutron results in the release of a-particles that kill cancer cells. To attach 10BPA, the surface of BPMO was modified with diol groups which facilitated the efficient binding of 10BPA, yielding 10BPA-loaded BPMO (10BPA-BPMO). Surface modification with phosphonate was also carried out to increase the dispersibility of the nanoparticles. To investigate this nanomaterial’s potential for BNCT, we first used human cancer cells and found that 10BPA-BPMO nanoparticles were efficiently taken up into the cancer cells and were localized in perinuclear regions. We then used a chicken egg tumor model, a versatile and convenient tumor model used to characterize nanomaterials. After observing significant tumor accumulation, 10BPA-BPMO injected chicken eggs were evaluated by irradiating with neutron beams. Dramatic inhibition of the tumor growth was observed. These results suggest the potential of 10BPA-BPMO as a novel boron agent for BNCT.

Light-harvesting photocatalysis for H2 evolution by methylacridone-bridged periodic mesoporous organosilica

2021 ◽  
Vol 287 ◽  
pp. 119965
Author(s):  
Yasutomo Goto ◽  
Ken-ichi Yamanaka ◽  
Masataka Ohashi ◽  
Yoshifumi Maegawa ◽  
Shinji Inagaki
Keyword(s):  
Light Harvesting ◽  
H2 Evolution ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica
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