The Risk of Rupture and Abdominal Aortic Aneurysm Morphology: a computational study

2021 ◽  
Author(s):  
Josip Živić ◽  
Lana Virag ◽  
Nino Horvat ◽  
Marija Smoljkić ◽  
Igor Karšaj
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Computational Study ◽  
Abdominal Aortic ◽  
Risk Of Rupture ◽  
Aneurysm Morphology

Current evidence and prospects for medical treatment of abdominal aortic aneurysms

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 217-223 ◽  
Author(s):  
Diehm ◽  
Schmidli ◽  
Dai-Do ◽  
Baumgartner
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Medical Treatment ◽  
Endovascular Treatment ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Current Evidence ◽  
Significant Morbidity ◽  
Abdominal Aortic ◽  
Risk Of Rupture

Abdominal aortic aneurysm (AAA) is a potentially fatal condition with risk of rupture increasing as maximum AAA diameter increases. It is agreed upon that open surgical or endovascular treatment is indicated if maximum AAA diameter exceeds 5 to 5.5cm. Continuing aneurysmal degeneration of aortoiliac arteries accounts for significant morbidity, especially in patients undergoing endovascular AAA repair. Purpose of this review is to give an overview of the current evidence of medical treatment of AAA and describe prospects of potential pharmacological approaches towards prevention of aneurysmal degeneration of small AAAs and to highlight possible adjunctive medical treatment approaches after open surgical or endovascular AAA therapy.

Gender differences in abdominal aortic aneurysm therapy – a systematic review

VASA ◽  
2018 ◽  
Vol 47 (4) ◽  
pp. 267-272 ◽  
Author(s):  
Konstanze Stoberock ◽  
Tilo Kölbel ◽  
Gülsen Atlihan ◽  
Eike Sebastian Debus ◽  
Nikolaos Tsilimparis ◽  
...  
Keyword(s):  
Gender Differences ◽  
Abdominal Aortic Aneurysm ◽  
Survival Rate ◽  
Aortic Aneurysm ◽  
Endovascular Treatment ◽  
Aortic Aneurysms ◽  
Lower Survival Rate ◽  
Lower Survival ◽  
Abdominal Aortic ◽  
Risk Of Rupture

Abstract. This article analyses if and to what extent gender differences exist in abdominal aortic aneurysm (AAA) therapy. For this purpose Medline (PubMed) was searched from January 1999 to January 2018. Keywords were: “abdominal aortic aneurysm”, “gender”, “prevalence”, “EVAR”, and “open surgery of abdominal aortic aneurysm”. Regardless of open or endovascular treatment of abdominal aortic aneurysms, women have a higher rate of complications and longer hospitalizations compared to men. The majority of studies showed that women have a lower survival rate for surgical and endovascular treatment of abdominal aneurysms after both elective and emergency interventions. Women receive less surgical/interventional and protective medical treatment. Women seem to have a higher risk of rupture, a lower survival rate in AAA, and a higher rate of complications, regardless of endovascular or open treatment. The gender differences may be due to a higher age of women at diagnosis and therapy associated with higher comorbidity, but also because of genetic, hormonal, anatomical, biological, and socio-cultural differences. Strategies for treatment in female patients must be further defined to optimize outcome.

scholarly journals Comparison of open versus endovascular surgical treatment of abdominal aortic aneurysm

2020 ◽  
Vol 6 (3) ◽  
pp. 477-480
Author(s):  
Sabine Kischkel ◽  
Carsten M. Bünger
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Treatment Options ◽  
Prosthetic Graft ◽  
Healthcare Research ◽  
Vascular Medicine ◽  
Related Complication ◽  
Abdominal Aortic ◽  
Open Aortic Repair ◽  
Risk Of Rupture

AbstractAbdominal aortic aneurysm (AAA) is a common condition of increasing prevalence, particularly among older men. An AAA is defined as a permanent dilation of the abdominal aorta, with a diameter greater than 30 mm or a diameter greater than 50% of the aortic diameter at the level of the diaphragm. As the size of the aneurysm increases, so does the risk of rupture. Therefore, prophylactic repair with insertion of a prosthetic graft is offered. Since 1951 traditional open aneurysm repair (OAR) was reported and minimally invasive endovascular repair (EVAR) was first reported in 1986. Data from four randomized controlled trials (EVAR-1, DREAM, OVER, ACE) for abdominal aortic aneurysm, which enrolled almost 3000 patients, in a period from 1999 to 2008, were summarized. In addition, registry databases on the treatment of AAA of average 4000 patients per year, based from 2015 to 2018 of the German Institute for Vascular Medicine Healthcare Research of the German Society for Vascular Surgery and Vascular Medicine, were compared. The EVAR procedure for AAA showed a lower risk of perioperative mortality but was associated with a higher cardiovascular and aneurysm-related complication rate. In particular, patients aged 80 years or older benefited from EVAR since the 30-day mortality of patients receiving OAR was higher. In mid-term and long-term follow-up there were no differences in survival after endovascular and open aortic repair. Overall, it depends on the respective underlying disease and anatomy which of the two approaches is to be preferred. In conclusion, both treatment options can be considered as equal and can be offered to patients.

Challenges of applying circulating biomarkers for abdominal aortic aneurysm progression

2021 ◽  
pp. 153537022199253
Author(s):  
Yuan Li ◽  
Dan Yang ◽  
Yuehong Zheng
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Prognostic Models ◽  
Rapid Progression ◽  
Circulating Biomarkers ◽  
Invasive Treatment ◽  
Abdominal Symptoms ◽  
Abdominal Aortic ◽  
Risk Of Rupture ◽  
Threatening Condition

As a prevalent potentially life-threatening condition, abdominal aortic aneurysm (AAA) presents increasing risk of rupture as its diameter grows. However, rapid progression and rupture may occasionally occur in smaller AAAs. Earlier surgery for patients with high risk of disease progression may improve the outcome. Therefore, more precise indicators for invasive treatment in addition to diameter and abdominal symptoms are demanded. This systematic review aimed to identify potential circulating biomarkers that may predict growth rate of AAA. Cochrane and PubMed library were searched (until August 2020) for researches which reported circulating biomarkers associated with AAA expansion, and 25 papers were included. Twenty-eight identified biomarkers were further classified into five categories (inflammation and oxidative stress, matrix degradation, hematology and lipid metabolism, thrombosis and fibrinolysis, and others), and discussed further with their correlation and regression analysis results. Larger prospective trials are required to establish and evaluate prognostic models with highest values with these markers.

Abdominal aortic aneurysm morphology: CT features in patients with ruptured and nonruptured aneurysms.

1994 ◽  
Vol 163 (5) ◽  
pp. 1123-1129 ◽  
Author(s):  
C L Siegel ◽  
R H Cohan ◽  
M Korobkin ◽  
M B Alpern ◽  
D L Courneya ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
Aneurysm Morphology ◽  
Ct Features

Intraluminal thrombus and risk of rupture in patient specific abdominal aortic aneurysm – FSI modelling

2009 ◽  
Vol 12 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Danny Bluestein ◽  
Kris Dumont ◽  
Matthieu De Beule ◽  
John Ricotta ◽  
Paul Impellizzeri ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Patient Specific ◽  
Intraluminal Thrombus ◽  
Abdominal Aortic ◽  
Risk Of Rupture

Investigating the Effect of Intraluminal Thrombus in Abdominal Aortic Aneurysm by Computational and Experimental Methods

2009 ◽  
Author(s):  
Florentina Ene ◽  
Carine Gachon ◽  
Patrick Delassus ◽  
Liam Morris
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
High Risk ◽  
Aortic Aneurysm ◽  
Abdominal Aorta ◽  
Experimental Methods ◽  
Infrarenal Aorta ◽  
Intraluminal Thrombus ◽  
Abdominal Aortic ◽  
Risk Of Rupture

Abdominal aortic aneurysm (AAA) represents an abnormal dilatation and weakening of the abdominal aorta with high risk of rupture. Most aneurysms of the infrarenal aorta possess an asymmetrical fusiform morphology.

scholarly journals Prediction of Abdominal Aortic Aneurysm Growth and Risk of Rupture in the Era of Machine Learning

Angiology ◽  
2020 ◽  
Vol 71 (8) ◽  
pp. 767-767
Author(s):  
Fabien Lareyre ◽  
Cédric Adam ◽  
Marion Carrier ◽  
Juliette Raffort
Keyword(s):  
Machine Learning ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
Risk Of Rupture ◽  
Aneurysm Growth
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