Theoretical Model of the Influence of Irreversibly Electroporated Cells on Post Pulse Drug Delivery to Reversibly Electroporated Cells

2021 ◽  
Author(s):  
Sid M. Becker
Keyword(s):  
Drug Delivery ◽  
Theoretical Model

scholarly journals Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates

2017 ◽  
Vol 7 ◽  
Author(s):  
Fatma E. El-Khouly ◽  
Dannis G. van Vuurden ◽  
Thom Stroink ◽  
Esther Hulleman ◽  
Gertjan J. L. Kaspers ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Theoretical Model ◽  
Diffuse Intrinsic Pontine Glioma ◽  
Effective Drug ◽  
Pontine Glioma

scholarly journals Poly(vinyl alcohol boric acid)-Diclofenac Sodium Salt Drug Delivery Systems: Experimental and Theoretical Studies

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Daniela Ailincai ◽  
Alexandra Maria Dorobanțu ◽  
Bogdan Dima ◽  
Ștefan Andrei Irimiciuc ◽  
Cristian Lupașcu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Theoretical Model ◽  
Drug Release ◽  
Mathematical Models ◽  
Boric Acid ◽  
Sodium Salt ◽  
Vinyl Alcohol ◽  
Drug Delivery Systems ◽  
Diclofenac Sodium ◽  
Poly Vinyl Alcohol

The main aim of the paper was to simulate the drug release by a multifractal theoretical model, as a valuable method to assess the drug release mechanism. To do this, drug delivery films were prepared by mixing poly(vinyl alcohol boric acid) (PVAB) and diclofenac (DCF) sodium salt drug in different mass ratios from 90/10 to 70/30, in order to obtain drug delivery systems with different releasing rates. The different drug content of the three systems was confirmed by energy-dispersive spectroscopy (EDAX) analysis, and the encapsulation particularities were investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM), and polarized optical microscopy (POM) techniques. The ability of the PVAB matrix to anchor the DCF was assessed by Fourier transform infrared (FTIR) spectroscopy. The in vitro release of the diclofenac sodium salt from the formulations was investigated in biomimetic conditions (pH=7.4 and 37°C) by UV-Vis spectroscopy, measuring the absorbance of the drug at 275 nm and fitting the results on a previously drawn calibration curve. An estimation of the drug release kinetics was performed by fitting three traditional mathematical models on experimental release data. Further, the drug delivery was simulated by the fractal theory of motion, in which the release dynamics of the polymer-drug complex system is described through various Riccati-type “regimes.” To explain such dynamics involved multifractal self-modulation in the form of period doubling, quasiperiodicity, intermittency, etc., as well as multifractal self-modulation of network type. Standard release dynamics were explained by multifractal behaviors of temporary kink type. The good correlation between the traditional mathematical models and the new proposed theoretical model demonstrated the validity of the multifractal model for the investigation of the drug release.

Novel pKa/DFT-Based Theoretical Model for Predicting the Drug Loading and Release of a pH-Responsive Drug Delivery System

2018 ◽  
Vol 122 (23) ◽  
pp. 12279-12290 ◽  
Author(s):  
Shaukatali N. Inamdar ◽  
Khalid Ahmed ◽  
Nashiour Rohman ◽  
Adam A. Skelton
Keyword(s):  
Drug Delivery ◽  
Theoretical Model ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Ph Responsive

Trajectory Simulation of Magnetic Nanoparticles in the Blood Vessel for the Magnetic Targeted-Drug Delivery

2013 ◽  
Vol 753-755 ◽  
pp. 988-994 ◽  
Author(s):  
Jie Feng ◽  
Rui Lin Zhang ◽  
Ya Nan Qu ◽  
Ping Geng ◽  
Shou Liang Qi
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Theoretical Model ◽  
Blood Vessel ◽  
Targeted Drug Delivery ◽  
Magnetic Circuit ◽  
Critical Parameters ◽  
Retention Ratio ◽  
Targeted Drug

Magnetic nanoparticles (MNPs) have been considered as potential therapeutic agent carrier for the magnetic targeted-drug delivery in the fight against cancer. Trajectories of MNPs in the blood vessel determine the capture and retention ratio, and the final effectiveness of the treatment. In the present study, a theoretical model of MNPs trajectory is deduced at first. Then two kinds of magnets are proposed, and their magnetic field distributions are calculated through the finite element method software of ANSYS. Using the model and magnetic field inputs, the MNPs trajectories are determined, and the influences of the MNP diameter (Rp), the blood flow velocity (vf) and magnetic field intensity (H) on the trajectories are clarified finally. It is found that the proposed method combining the theoretical model and numerical simulation is feasible. The closed magnetic circuit with concave-convex poles has better MNPs retention ratio than that of the open magnetic circuit because it has higher H and Grad (H). LargeRp, lowvf, and high H are good to capture the MNPs. Especiallyvfand H are critical parameters for the retention ratio of MNPs, and highvfand low H may let MNPs escape the magnetic field region.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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