Modelling the action potential propagation in a heart with structural heterogeneities: From high‐resolution MRI to numerical simulations

Author(s):  
Anđela Davidović ◽  
Yves Coudière ◽  
Yves Bourgault
2013 ◽  
Vol 235 ◽  
pp. 42-49 ◽  
Author(s):  
Daniel Edelhoff ◽  
Lars Walczak ◽  
Stefan Henning ◽  
Frank Weichert ◽  
Dieter Suter

Author(s):  
Joachim R. Sommer ◽  
Teresa High ◽  
Betty Scherer ◽  
Isaiah Taylor ◽  
Rashid Nassar

We have developed a model that allows the quick-freezing at known time intervals following electrical field stimulation of a single, intact frog skeletal muscle fiber isolated by sharp dissection. The preparation is used for studying high resolution morphology by freeze-substitution and freeze-fracture and for electron probe x-ray microanlysis of sudden calcium displacement from intracellular stores in freeze-dried cryosections, all in the same fiber. We now show the feasibility and instrumentation of new methodology for stimulating a single, intact skeletal muscle fiber at a point resulting in the propagation of an action potential, followed by quick-freezing with sub-millisecond temporal resolution after electrical stimulation, followed by multiple sampling of the frozen muscle fiber for freeze-substitution, freeze-fracture (not shown) and cryosectionmg. This model, at once serving as its own control and obviating consideration of variances between different fibers, frogs etc., is useful to investigate structural and topochemical alterations occurring in the wake of an action potential.


Author(s):  
Alan P. Koretsky ◽  
Afonso Costa e Silva ◽  
Yi-Jen Lin

Magnetic resonance imaging (MRI) has become established as an important imaging modality for the clinical management of disease. This is primarily due to the great tissue contrast inherent in magnetic resonance images of normal and diseased organs. Due to the wide availability of high field magnets and the ability to generate large and rapidly switched magnetic field gradients there is growing interest in applying high resolution MRI to obtain microscopic information. This symposium on MRI microscopy highlights new developments that are leading to increased resolution. The application of high resolution MRI to significant problems in developmental biology and cancer biology will illustrate the potential of these techniques.In combination with a growing interest in obtaining high resolution MRI there is also a growing interest in obtaining functional information from MRI. The great success of MRI in clinical applications is due to the inherent contrast obtained from different tissues leading to anatomical information.


2006 ◽  
Vol 22 (06) ◽  
Author(s):  
Robert Spinner ◽  
Toshiki Endo ◽  
Eric Dozois ◽  
Kimberly Amarami

2021 ◽  
Author(s):  
Karl‐Heinz Herrmann ◽  
Franziska Hoffmann ◽  
Günther Ernst ◽  
David Pertzborn ◽  
Daniela Pelzel ◽  
...  

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