scholarly journals A semi‐active human digital twin model for detecting severity of carotid stenoses from head vibration—A coupled computational mechanics and computer vision method

2019 ◽  
Vol 35 (5) ◽  
pp. e3180 ◽  
Author(s):  
Neeraj Kavan Chakshu ◽  
Jason Carson ◽  
Igor Sazonov ◽  
Perumal Nithiarasu
Keyword(s):  
Computer Vision ◽  
Computational Mechanics ◽  
Digital Twin ◽  
Twin Model ◽  
Carotid Stenoses

scholarly journals Graph Representation Forecasting of Patient's Medical Conditions: Toward a Digital Twin

2021 ◽  
Vol 12 ◽  
Author(s):  
Pietro Barbiero ◽  
Ramon Viñas Torné ◽  
Pietro Lió
Keyword(s):  
Blood Pressure ◽  
Tissue Expression ◽  
Modern Medicine ◽  
Cellular Level ◽  
Graph Representation ◽  
Modular Architecture ◽  
Panoramic View ◽  
Generative Adversarial Network ◽  
Digital Twin ◽  
Twin Model

Objective: Modern medicine needs to shift from a wait and react, curative discipline to a preventative, interdisciplinary science aiming at providing personalized, systemic, and precise treatment plans to patients. To this purpose, we propose a “digital twin” of patients modeling the human body as a whole and providing a panoramic view over individuals' conditions.Methods: We propose a general framework that composes advanced artificial intelligence (AI) approaches and integrates mathematical modeling in order to provide a panoramic view over current and future pathophysiological conditions. Our modular architecture is based on a graph neural network (GNN) forecasting clinically relevant endpoints (such as blood pressure) and a generative adversarial network (GAN) providing a proof of concept of transcriptomic integrability.Results: We tested our digital twin model on two simulated clinical case studies combining information at organ, tissue, and cellular level. We provided a panoramic overview over current and future patient's conditions by monitoring and forecasting clinically relevant endpoints representing the evolution of patient's vital parameters using the GNN model. We showed how to use the GAN to generate multi-tissue expression data for blood and lung to find associations between cytokines conditioned on the expression of genes in the renin–angiotensin pathway. Our approach was to detect inflammatory cytokines, which are known to have effects on blood pressure and have previously been associated with SARS-CoV-2 infection (e.g., CXCR6, XCL1, and others).Significance: The graph representation of a computational patient has potential to solve important technological challenges in integrating multiscale computational modeling with AI. We believe that this work represents a step forward toward next-generation devices for precision and predictive medicine.

scholarly journals Analyzing the Manufacturing Supply Chain Performance for Urgent Item During COVID-19 Outbreak

2021 ◽  
Vol 9 (1) ◽  
pp. 15-31
Author(s):  
Ali Arishi ◽  
Krishna K Krishnan ◽  
Vatsal Maru
Keyword(s):  
Raw Materials ◽  
Early Stage ◽  
Supply And Demand ◽  
Network Models ◽  
Combine System ◽  
Neural Network Models ◽  
Digital Twin ◽  
Twin Model ◽  
The Impact ◽  
Reaction Patterns

As COVID-19 pandemic spreads in different regions with varying intensity, supply chains (SC) need to utilize an effective mechanism to adjust spike in both supply and demand of resources, and need techniques to detect unexpected behavior in SC at an early stage. During COVID-19 pandemic, the demand of medical supplies and essential products increases unexpectedly while the availability of recourses and raw materials decreases significantly. As such, the questions of SC and society survivability were raised. Responding to this urgent demand quickly and predicting how it will vary as the pandemic progresses is a key modeling question. In this research, we take the initiative in addressing the impact of COVID-19 disruption on manufacturing SC performance overwhelmed by the unprecedented demands of urgent items by developing a digital twin model for the manufacturing SC. In this model, we combine system dynamic simulation and artificial intelligence to dynamically monitor SC performance and predict SC reaction patterns. The simulation modeling is used to study the disruption propagation in the manufacturing SC and the efficiency of the recovery policy. Then based on this model, we develop artificial neural network models to learn from disruptions and make an online prediction of potential risks. The developed digital twin model is aimed to operate in real-time for early identification of disruptions and the respective SC reaction patterns to increase SC visibility and resilience.

scholarly journals Construction of Intelligent Integrated Model Framework for the Workshop Manufacturing System Via Digital Twin

2021 ◽  
Author(s):  
Zhongyu Zhang ◽  
Zhenjie Zhu ◽  
Jinsheng Zhang ◽  
Jingkun Wang
Keyword(s):  
Real Time ◽  
Production System ◽  
Manufacturing System ◽  
System Optimization ◽  
Production Cycle ◽  
Model Framework ◽  
The Real ◽  
Digital Twin ◽  
Twin Model ◽  
Information Layer

Abstract With the drastic development of the globally advanced manufacturing industry, transition of the original production pattern from traditional industries to advanced intelligence is completed with the least delay possible, which are still facing new challenges. Because the timeliness, stability and reliability of them is significantly restricted due to lack of the real-time communication. Therefore, an intelligent workshop manufacturing system model framework based on digital twin is proposed in this paper, driving the deep inform integration among the physical entity, data collection, and information decision-making. The conceptual and obscure of the traditional digital twin is refined, optimized, and upgraded on the basis of the four-dimension collaborative model thinking. A refined nine-layer intelligent digital twin model framework is established. Firstly, the physical evaluation is refined into entity layer, auxiliary layer and interface layer, scientifically managing the physical resources as well as the operation and maintenance of the instrument, and coordinating the overall system. Secondly, dividing the data evaluation into the data layer and the processing layer can greatly improve the flexible response-ability and ensure the synchronization of the real-time data. Finally, the system evaluation is subdivided into information layer, algorithm layer, scheduling layer, and functional layer, developing flexible manufacturing plan more reasonably, shortening production cycle, and reducing logistics cost. Simultaneously, combining SLP and artificial bee colony are applied to investigate the production system optimization of the textile workshop. The results indicate that the production efficiency of the optimized production system is increased by 34.46%.

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