A methodology for determining optimal thermal damage in magnetic nanoparticle hyperthermia cancer treatment

2011 ◽  
Vol 28 (2) ◽  
pp. 205-213 ◽  
Author(s):  
Manu Mital ◽  
Hooman V. Tafreshi
Keyword(s):  
Cancer Treatment ◽  
Magnetic Nanoparticle ◽  
Thermal Damage ◽  
Magnetic Nanoparticle Hyperthermia

Nanoparticle Redistribution During Magnetic Nanoparticle Hyperthermia: Multi-Physics Porous Medium Model Analyses

2012 ◽  
Author(s):  
Anilchandra Attaluri ◽  
Robert Ivkov ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Heat Transfer ◽  
Porous Media ◽  
Magnetic Nanoparticle ◽  
Thermal Damage ◽  
Heat Transfer Model ◽  
Transfer Model ◽  
Model Based ◽  
Porous Media Model ◽  
Magnetic Nanoparticle Hyperthermia ◽  
And Diffusion

A coupled theoretical framework comprising a suspension of nanoparticles transport in porous media model and a heat transfer model is developed to address nanoparticle redistribution during heating. Nanoparticle redistribution in biological tissues during magnetic nanoparticle hyperthermia is described by a multi-physics model that consists of five major components: (a) a fully saturated porous media model for fluid flow through tissue; (b) nanoparticle convection and diffusion; (c) heat transfer model based on heat generation by local nanoparticle concentration; (d) a model to predict tissue thermal damage and corresponding change to the porous structure; and (e) a nanoparticle redistribution model based on the dynamic porosity and diffusion diffusivity. The integrated model has been used to predict the structural damage in porous tumors and its effect on nanoparticle-induced heating in tumors. Thermal damage in the vicinity of the tumor center that is predicted by the Arrhenius equation increases from 14% with 10 minutes of heating to almost 99% after 20 minutes. It then induces an increased tumor porosity that increases nanoparticle diffusivity by seven-fold. The model predicts thermal damage induced by nanoparticle redistribution increases by 20% in the radius of the spherical tissue region containing nanoparticles. The developed model has demonstrated the feasibility of enhancing nanoparticle dispersion from injection sites using targeted thermal damage.

Magnetic Nanoparticle Hyperthermia for Cancer Treatment: a Review On Nanoparticle Types and Thermal Analyses

2021 ◽  
Author(s):  
Kassianne J Tofani ◽  
Saeed Tiari
Keyword(s):  
Temperature Distribution ◽  
Cancer Treatment ◽  
Magnetic Nanoparticle ◽  
Thermal Analyses ◽  
Blood Perfusion ◽  
Bioheat Transfer ◽  
Manganese Zinc ◽  
Different Types ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Future Work

Abstract Magnetic nanoparticle hyperthermia (MNH) is a localized cancer treatment which uses an alternating magnetic field to excite magnetic nanoparticles (MNPs) injected into a tumor, causing them to generate heat. Once the temperature of the tumor tissue reaches about 43°C, the cancerous cells die. Different types of MNPs have been studied, including iron oxides with various coatings, Cu-Ni alloys and complex manganese/zinc particles. This paper reviews different types of MNPs and assesses them by magnetization, SAR, and Curie Temperature. We reviewed the achievements and limitations of the works in this field. A major issue with MNH is maintaining effective hyperthermia while preserving healthy tissue. Numerical modeling can predict temperature distribution and safely simulate hyperthermia. The most used bioheat transfer equation is Pennes' equation which includes a term for blood perfusion, an important factor for temperature distribution. While some models safely neglect it, most include blood perfusion term. Some recent models have also included large blood vessels, others used their own heat transfer models. This article reviews the different models and classifies them based on how they address blood flow. A need for studies with realistic tumor shapes was identified. The irregular shape of most tumors could result in less uniform temperature distribution than in the commonly used circular or spherical models. This article aims to identify potential future work to create more realistic tumor models.

scholarly journals Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment

2013 ◽  
Vol 29 (8) ◽  
pp. 845-851 ◽  
Author(s):  
Alicia A. Petryk ◽  
Andrew J. Giustini ◽  
Rachel E. Gottesman ◽  
Peter A. Kaufman ◽  
P. Jack Hoopes
Keyword(s):  
Cancer Treatment ◽  
Magnetic Nanoparticle ◽  
Magnetic Nanoparticle Hyperthermia

Treatment Efficacy for Validating MicroCT-Based Theoretical Simulation Approach in Magnetic Nanoparticle Hyperthermia for Cancer Treatment

2017 ◽  
Vol 139 (5) ◽  
Author(s):  
Alexander LeBrun ◽  
Tejashree Joglekar ◽  
Charles Bieberich ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Treatment Efficacy ◽  
Magnetic Nanoparticle ◽  
Thermal Damage ◽  
Theoretical Models ◽  
Control Group ◽  
Tumor Shrinkage ◽  
Tumor Cell Death ◽  
Theoretical Simulation ◽  
Magnetic Nanoparticle Hyperthermia

The objective is to validate a designed heating protocol in a previous study based on treatment efficacy of magnetic nanoparticle hyperthermia in prostate tumors. In vivo experiments have been performed to induce temperature elevations in implanted PC3 tumors injected with magnetic nanoparticles, following the same heating protocol designed in our previous microCT-based theoretical simulation. A tumor shrinkage study and histological analyses of tumor cell death are conducted after the heating. Tumor shrinkage is observed over a long period of 8 weeks. Histological analyses of the tumors after heating are used to evaluate whether irreversible thermal damage occurs in the entire tumor region. It has been shown that the designed 25 min heating (Arrhenius integral Ω ≥ 4 in the entire tumor) on tumor tissue is effective to cause irreversible thermal damage to PC3 tumors, while reducing the heating time to 12 min (Ω ≥ 1 in the entire tumor) results in an initial shrinkage, however, later tumor recurrence. The treated tumors with 25 min of heating disappear after only a few days. On the other hand, the tumors in the control group without heating show approximately an increase of more than 700% in volume over the 8-week observation period. In the undertreated group with 12 min of heating, its growth rate is smaller than that in the control group. In addition, results of the histological analysis suggest vast regions of apoptotic and necrotic cells, consistent with the regions of significant temperature elevations. In conclusion, this study demonstrates the importance of imaging-based design for individualized treatment planning. The success of the designed heating protocol for completely damaging PC3 tumors validates the theoretical models used in planning heating treatment in magnetic nanoparticle hyperthermia.

Temperature Distribution and Thermal Dosage Affected by Nanoparticle Distribution in Tumours During Magnetic Nanoparticle Hyperthermia

2019 ◽  
Author(s):  
Manpreet Singh ◽  
Qimei Gu ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Magnetic Nanoparticle ◽  
Thermal Damage ◽  
Local Heating ◽  
Heating Time ◽  
Control Group ◽  
Theoretical Simulation ◽  
Nanoparticle Distribution ◽  
Tumor Periphery ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Experimental Group

Abstract Recent microCT imaging study has demonstrated that local heating caused a much larger nanoparticle distribution volume in tumors than that in tumors without localized heating, suggesting possible nanoparticle redistribution/migration during heating. In this study, a theoretical simulation is performed to evaluate to what extent the nanoparticle redistribution affects the temperature elevations and thermal dosage required to cause permanent thermal damage to PC3 tumors. Two tumor groups with similar sizes are selected. The control group consists of five PC3 tumors with nanoparticles distribution without heating, while the experimental group consists of another five resected PC3 tumors with nanoparticles distribution obtained after 25 minutes of local heating. Each generated tumor model is attached to a mouse body model by microCT scans. A previously determined relationship between the nanoparticle concentration distribution and the volumetric heat generation rate is implemented in the theoretical simulation of temperature elevations during magnetic nanoparticle hyperthermia. Our simulation results show that the average steady state temperature elevation in the tumors of the control group is higher than that in the experimental group when the nanoparticles are more spreading from the tumor center to tumor periphery (control group: 64.03±3.2°C vs. experimental group: 62.04±3.07°C). Further we assess the thermal dosage needed to cause 100% permanent thermal damage (Arrhenius integral Ω = 4) to the entire tumor, based on the assumption of unchanged nanoparticle distribution during heating. The average heating time based on the experimental setting from our previous studies demonstrates significantly different designs. Specifically, the average heating time for the control group is 24.3 minutes. However, the more spreading of nanoparticles to tumor periphery in the experimental group results in a much longer heating time of 38.1 minutes, 57° longer than that in the control group, to induce permanent thermal damage to the entire tumor. The results from this study suggest that the heating time needed when considering dynamic nanoparticle migration during heating is probably between 24 to 38 minutes. In conclusion, the study demonstrates the importance of including dynamic nanoparticle spreading during heating into theoretical simulation of temperature elevations in tumors to determine accurate thermal dosage needed in magnetic nanoparticle hyperthermia design.

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