scholarly journals Patient-specific computational biomechanics for simulating adolescent scoliosis surgery: Predicted vs clinical correction for a preliminary series of six patients

2010 ◽  
Vol 27 (3) ◽  
pp. 347-356 ◽  
Author(s):  
J. Paige Little ◽  
Clayton Adam
Keyword(s):  
Patient Specific ◽  
Scoliosis Surgery ◽  
Computational Biomechanics

scholarly journals Simulation of atherosclerotic plaque growth using computational biomechanics and patient-specific data

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Dimitrios S. Pleouras ◽  
Antonis I. Sakellarios ◽  
Panagiota Tsompou ◽  
Vassiliki Kigka ◽  
Savvas Kyriakidis ◽  
...  
Keyword(s):  
Disease Progression ◽  
Plaque Burden ◽  
Patient Specific ◽  
High Density Lipoproteins ◽  
Computational Biomechanics ◽  
Plaque Area ◽  
Causes Of Mortality ◽  
Plaque Growth ◽  
Atherosclerotic Process ◽  
The One

Abstract Atherosclerosis is the one of the major causes of mortality worldwide, urging the need for prevention strategies. In this work, a novel computational model is developed, which is used for simulation of plaque growth to 94 realistic 3D reconstructed coronary arteries. This model considers several factors of the atherosclerotic process even mechanical factors such as the effect of endothelial shear stress, responsible for the initiation of atherosclerosis, and biological factors such as the accumulation of low and high density lipoproteins (LDL and HDL), monocytes, macrophages, cytokines, nitric oxide and formation of foams cells or proliferation of contractile and synthetic smooth muscle cells (SMCs). The model is validated using the serial imaging of CTCA comparing the simulated geometries with the real follow-up arteries. Additionally, we examine the predictive capability of the model to identify regions prone of disease progression. The results presented good correlation between the simulated lumen area (P < 0.0001), plaque area (P < 0.0001) and plaque burden (P < 0.0001) with the realistic ones. Finally, disease progression is achieved with 80% accuracy with many of the computational results being independent predictors.

Patient-specific computational biomechanics of the brain without segmentation and meshing

2012 ◽  
Vol 29 (2) ◽  
pp. 293-308 ◽  
Author(s):  
Johnny Y. Zhang ◽  
Grand Roman Joldes ◽  
Adam Wittek ◽  
Karol Miller
Keyword(s):  
Patient Specific ◽  
Computational Biomechanics ◽  
The Brain

scholarly journals Patient-Specific Templates for Pedicle Screw Insertion in Spinal Fixation Surgery

10.29007/kbf7 ◽  
2018 ◽  
Author(s):  
Mahmoud Hafez ◽  
Mohamed Fouda
Keyword(s):  
Pedicle Screw ◽  
3D Model ◽  
Pedicle Screws ◽  
Ct Scans ◽  
Patient Specific ◽  
Scoliosis Surgery ◽  
Spinal Fixation ◽  
Screw Insertion ◽  
Pedicle Screw Insertion ◽  
Surgery Patient

The increased use of pedicle screws in scoliosis creates a challenge for accurate and safe placement ofscrew within the pedicle during the scoliosis surgery. Patient-specific templates (PST) is a novelmethod to guide the surgeons for allocating and detecting the positions and trajectories of pediclescrews in scoliosis surgery. Based on CT-scans and according to certain protocol, this technique willallow the surgeon to construct a 3D model of spine and present the stage and vertebrae which containthe most deformed bone. With preplanned surgery on specific software, we can develop an accurateand safe position of pedicle screws and its trajectories. This method has the ability to customize theplacement and the size of each pedicle screw based on the unique morphology and landmarks of thevertebrae.

J0206-2-6 Development of a patient-specific aortic aneurysm model based on computational biomechanics

2010 ◽  
Vol 2010.6 (0) ◽  
pp. 95-96
Author(s):  
Kazutoshi MIYASHITA ◽  
Koichi SUGIMOTO ◽  
Fuyou LIANG ◽  
Ken-ichi TSUBOTA ◽  
Hao LIU
Keyword(s):  
Aortic Aneurysm ◽  
Patient Specific ◽  
Computational Biomechanics ◽  
Model Based ◽  
Aneurysm Model

Adolescent idiopathic scoliosis surgery with patient-specific screw placement-guides

2014 ◽  
Vol 23 (12) ◽  
pp. 2765-2766 ◽  
Author(s):  
C. Lamartina ◽  
A. Capuzzo ◽  
R. Cecchinato ◽  
A. Zerbi ◽  
P. Berjano
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Screw Placement ◽  
Patient Specific ◽  
Scoliosis Surgery

A finite element study on intra-operative corrective forces and evaluation of screw density in scoliosis surgeries

2018 ◽  
Vol 232 (12) ◽  
pp. 1245-1254 ◽  
Author(s):  
Ameneh Musapoor ◽  
Mohammad Nikkhoo ◽  
Mohammad Haghpanahi
Keyword(s):  
Finite Element ◽  
Pedicle Screws ◽  
Element Model ◽  
Applied Force ◽  
Patient Specific ◽  
Scoliosis Surgery ◽  
Element Analysis ◽  
Clinical Images ◽  
Significant Difference ◽  
Screw Density

Scoliosis is an abnormal sideways curvature of the spine and rib cage, which may need surgical treatments. Most of the corrective maneuvers in scoliosis surgeries are based on surgeon’s experience; hence, there is great interest of understanding how the correction ratio can be influenced by the magnitude of forces and moments. Therefore, the objective of this study was to develop and validate a detailed finite element model of the thoracolumbar which can be used to simulate the scoliosis surgeries based on patient-specific clinical images. The validated models of five patients were carefully developed, and the surgery procedures were simulated and the corrective forces were estimated using inverse finite element analysis during the surgery. Furthermore, parametric studies including the influences of the corrective force magnitude and screw density were evaluated. The results showed that the maximum estimated correction force and moment were 173 (±55.43) N and 10.67 (±2.02) N m, respectively, which were aligned with measured clinical observations. The sensitivity analysis on the magnitude of applied force to the screws showed that correction ratio was slightly increased in level 1 (i.e. FB = 1.3 ×  F) but decreased in level 2 (i.e. FB = 1.6 ×  F). In addition, the parametric study on increasing the number of pedicle screws showed that there was no significant difference between lower and higher screw density. However, the stress distribution was significantly greater using higher screw density during correction maneuvers. In conclusion, this study shows a direct relationship between the applied force/moment and screw density and the correction ratio up to a border line which should be defined accurately. This detailed computational modeling can be used in clinic in hope of achieving the optimum outcome of scoliosis surgery using individual patient-specific characterization.

scholarly journals Subject-Specific Analysis of Joint Contact Mechanics: Application to the Study of Osteoarthritis and Surgical Planning

2013 ◽  
Vol 135 (2) ◽  
Author(s):  
Corinne R. Henak ◽  
Andrew E. Anderson ◽  
Jeffrey A. Weiss
Keyword(s):  
Contact Mechanics ◽  
Computational Models ◽  
Preoperative Planning ◽  
Patient Specific ◽  
Joint Mechanics ◽  
Imaging Data ◽  
Computational Biomechanics ◽  
Subject Specific ◽  
Joint Contact ◽  
Technical Considerations

Advances in computational mechanics, constitutive modeling, and techniques for subject-specific modeling have opened the door to patient-specific simulation of the relationships between joint mechanics and osteoarthritis (OA), as well as patient-specific preoperative planning. This article reviews the application of computational biomechanics to the simulation of joint contact mechanics as relevant to the study of OA. This review begins with background regarding OA and the mechanical causes of OA in the context of simulations of joint mechanics. The broad range of technical considerations in creating validated subject-specific whole joint models is discussed. The types of computational models available for the study of joint mechanics are reviewed. The types of constitutive models that are available for articular cartilage are reviewed, with special attention to choosing an appropriate constitutive model for the application at hand. Issues related to model generation are discussed, including acquisition of model geometry from volumetric image data and specific considerations for acquisition of computed tomography and magnetic resonance imaging data. Approaches to model validation are reviewed. The areas of parametric analysis, factorial design, and probabilistic analysis are reviewed in the context of simulations of joint contact mechanics. Following the review of technical considerations, the article details insights that have been obtained from computational models of joint mechanics for normal joints; patient populations; the study of specific aspects of joint mechanics relevant to OA, such as congruency and instability; and preoperative planning. Finally, future directions for research and application are summarized.

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