Selective upregulation of T?1 ?-tubulin and neuropeptide Y mRNAs after intermittent excitatory stimulation in adult rat hippocampus in vivo

1996 ◽  
Vol 367 (1) ◽  
pp. 132-146 ◽  
Author(s):  
Carrie G. Causing ◽  
Kenneth D. Makus ◽  
Yanling Ma ◽  
Freda D. Miller ◽  
William F. Comers
Keyword(s):  
Neuropeptide Y ◽  
Rat Hippocampus ◽  
Adult Rat

Kindling Induces Transient Changes in Neuronal Expression of Somatostatin, Neuropeptide Y, and Calbindin in Adult Rat Hippocampus and Fascia Dentata

Epilepsia ◽  
1994 ◽  
Vol 35 (6) ◽  
pp. 1299-1308 ◽  
Author(s):  
Niels Tonder ◽  
Jorn Kragh ◽  
Bente R. Finsen ◽  
Tom G. Bolwig ◽  
Jens Zimmer
Keyword(s):  
Neuropeptide Y ◽  
Rat Hippocampus ◽  
Fascia Dentata ◽  
Adult Rat ◽  
Neuronal Expression

scholarly journals Does 5-bromo-2′-deoxyuridine (BrdU) disrupt cell proliferation and neuronal maturation in the adult rat hippocampus in vivo?

2009 ◽  
Vol 199 (2) ◽  
pp. 218-221 ◽  
Author(s):  
Aneeka Hancock ◽  
Carolina Priester ◽  
Emily Kidder ◽  
Julian R. Keith
Keyword(s):  
Cell Proliferation ◽  
Rat Hippocampus ◽  
Neuronal Maturation ◽  
Adult Rat

scholarly journals Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-23 ◽  
Author(s):  
Muhammad Sohail Khan ◽  
Tahir Muhammad ◽  
Muhammad Ikram ◽  
Myeong Ok Kim
Keyword(s):  
Signaling Pathway ◽  
Neuroprotective Effect ◽  
Neuronal Cell ◽  
Memory Deficits ◽  
Akt Signaling ◽  
Rat Hippocampus ◽  
Akt Signaling Pathway ◽  
Adult Rats ◽  
Adult Rat

Curcumin is a natural polyphenolic compound widely known to have antioxidant, anti-inflammatory, and antiapoptotic properties. In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammation, neurodegeneration, and memory deficits in the adult rat hippocampus via regulation of the JNK/NF-κB/Akt signaling pathway. Adult rats were treated intraperitoneally with LPS at a dose of 250 μg/kg for 7 days and curcumin at a dose of 300 mg/kg for 14 days. After 14 days, the rats were sacrificed, and western blotting and ROS and lipid peroxidation assays were performed. For immunohistochemistry and confocal microscopy, the rats were perfused transcardially with 4% paraformaldehyde. In order to verify the JNK-dependent neuroprotective effect of curcumin and to confirm the in vivo results, HT-22 neuronal and BV2 microglial cells were exposed to LPS at a dose of 1 μg/ml, curcumin 100 μg/ml, and SP600125 (a specific JNK inhibitor) 20 μM. Our immunohistochemical, immunofluorescence, and biochemical results revealed that curcumin inhibited LPS-induced oxidative stress by reducing malondialdehyde and 2,7-dichlorofluorescein levels and ameliorating neuroinflammation and neuronal cell death via regulation of the JNK/NF-κB/Akt signaling pathway both in vivo (adult rat hippocampus) and in vitro (HT-22/BV2 cell lines). Moreover, curcumin markedly improved LPS-induced memory impairment in the Morris water maze and Y-maze tasks. Taken together, our results suggest that curcumin may be a potential preventive and therapeutic candidate for LPS-induced ROS-mediated neurotoxicity and memory deficits in an adult rat model.

scholarly journals In vivo phosphorylation sites in fetal and adult rat tau.

1993 ◽  
Vol 268 (34) ◽  
pp. 25712-25717
Author(s):  
A Watanabe ◽  
M Hasegawa ◽  
M Suzuki ◽  
K Takio ◽  
M Morishima-Kawashima ◽  
...  
Keyword(s):  
Phosphorylation Sites ◽  
Adult Rat
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