scholarly journals TrkA-immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin

1994 ◽  
Vol 350 (4) ◽  
pp. 587-611 ◽  
Author(s):  
Teresa Sobreviela ◽  
Douglas O. Clary ◽  
Louis F. Reichardt ◽  
Melanie M. Brandabur ◽  
Jeffrey H. Kordower ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Choline Acetyltransferase ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Nerve Growth ◽  
The Central Nervous System

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system

Neuron ◽  
1989 ◽  
Vol 2 (2) ◽  
pp. 1123-1134 ◽  
Author(s):  
Thomas H. Large ◽  
Gisela Weskamp ◽  
Judith C. Helder ◽  
Monte J. Radeke ◽  
Thomas P. Misko ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Developmental Expression ◽  
Nerve Growth

scholarly journals Immunohistochemical analysis of nerve growth factor receptor expression in normal and malignant human tissues.

1988 ◽  
Vol 36 (4) ◽  
pp. 383-389 ◽  
Author(s):  
P G Chesa ◽  
W J Rettig ◽  
T M Thomson ◽  
L J Old ◽  
M R Melamed
Keyword(s):  
Nervous System ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Normal Development ◽  
Malignant Tumors ◽  
Sympathetic Neurons ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Receptor Expression ◽  
Nerve Growth

Nerve growth factor (NGF) is a polypeptide important for normal development of the nervous system and promotion of survival and differentiation of sensory and sympathetic neurons in culture. The cellular effects of NGF are mediated by a specific cell surface molecule, nerve growth factor receptor (NGF-R). In the present study we have used a monoclonal antibody against human NGF-R to examine, by the avidin-biotin-immunoperoxidase method, the receptor distribution in a wide range of normal tissues and in more than 200 malignant tumors. Our results show that (a) human NGF-R is expressed in the peripheral nervous system but not in any of the central nervous system areas tested; (b) NGF-R expression is not restricted to neural tissues but is also found in a number of normal epithelial, mesenchymal, and lymphoid tissues; (c) NGF-R expression changes during normal development; and (d) NGF-R expression in malignant tumors generally parallels its normal tissue distribution. Thus, NGF-R is detected in a proportion of neuroectoderm-derived tumors, carcinomas, and lymphomas, and also in a characteristic group of small round-cell tumors (Ewing's sarcomas and embryonal rhabdomyosarcomas). These findings suggest a normal regulatory role for NGF in both neuronal and non-neuronal cells and identify a range of human tumors in which the NGF/NGF-R system may contribute to the malignant phenotype.

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