Comparative distribution of neurotensin-like immunoreactivity in the brain of a teleost (carassius auratus), an amphibian (hyla meridionalis), and a reptile (gallotia galloti)

1994 ◽  
Vol 348 (4) ◽  
pp. 511-530 ◽  
Author(s):  
Aixa R. Bello ◽  
Javier Milän ◽  
Isabelle Anglade ◽  
Argelia Martín ◽  
Isabel Negrín ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
The Brain ◽  
Gallotia Galloti

scholarly journals Biomarker Effects in Carassius auratus Exposure to Ofloxacin, Sulfamethoxazole and Ibuprofen

2019 ◽  
Vol 16 (9) ◽  
pp. 1628 ◽  
Author(s):  
Xiaofan Yang ◽  
Xiaoping Xu ◽  
Xueyu Wei ◽  
Jie Wan ◽  
Yu Zhang
Keyword(s):  
Ache Activity ◽  
Carassius Auratus ◽  
Crucian Carp ◽  
Hazard Quotient ◽  
Acetylcholinesterase Activity ◽  
Response To Treatment ◽  
Aquatic Environments ◽  
Combined Effects ◽  
Adverse Impacts ◽  
The Brain

Ofloxacin, sulfamethoxazole and ibuprofen are three commonly used drugs which can be detected in aquatic environments. To assess their ecotoxicity, the effects of these three pharmaceuticals and their mixture on AChE (acetylcholinesterase) activity in the brain, and EROD (7-ethoxyresorufin-O-deethylase) and SOD (superoxide dismutase) activities in the liver of the freshwater crucian carp Carassius auratus were tested after exposure for 1, 2, 4 and 7 days. The results showed that treatments with 0.002–0.01 mg/L ofloxacin and 0.0008–0.004 mg/L sulfamethoxazole did not significantly change AChE, EROD and SOD activities. AChE activity was significantly inhibited in response to treatment with >0.05mg/L ofloxacin and >0.02 mg/L sulfamethoxazole. All three biomarkers were induced significantly in treatments with ibuprofen and the mixture of the three pharmaceuticals at all the tested concentrations. The combined effects of ofloxacin, sulfamethoxazole and ibuprofen were compared with their isolated effects on the three biomarkers, and the results indicated that exposure to ibuprofen and the mixture at environmentally relevant concentrations could trigger adverse impacts on Carassius auratus. The hazard quotient (HQ) index also demonstrated a high risk for ibuprofen. Moreover, the present study showed that the effects of ofloxacin, sulfamethoxazole and ibuprofen might be additive on the physiological indices of Carassius auratus.

In-vivo evaluation of dopamine receptor-mediated inhibition of gonadotrophin secretion from the pituitary gland of the goldfish, Carassius auratus

1987 ◽  
Vol 114 (3) ◽  
pp. 449-458 ◽  
Author(s):  
R. J. Omeljaniuk ◽  
S. H. Shih ◽  
R. E. Peter
Keyword(s):  
Dopamine Receptor ◽  
Carassius Auratus ◽  
Time Course ◽  
Dopamine Antagonists ◽  
Serum Concentrations ◽  
In Vivo Evaluation ◽  
Goldfish Carassius Auratus ◽  
Dopamine Receptor Antagonists ◽  
The Brain

ABSTRACT Dopamine acts directly on the pituitary to modulate gonadotrophin (GtH) secretion in goldfish (Carassius auratus). In the light of this important role for dopamine in the regulation of goldfish reproduction, this investigation was designed to evaluate the receptor specificity of this dopamine inhibition and to describe the use of domperidone, a specific dopamine D2-receptor antagonist, in the manipulation of pituitary function in goldfish. To investigate the specificity of dopamine inhibition of GtH secretion, selected dopamine receptor antagonists were injected i.p. to block dopamine receptors thereby increasing GtH secretion as reflected by increased serum concentrations of GtH. Serum GtH levels were significantly increased by the active stereoisomer (−)-sulpiride in a dose-related fashion; (+)-sulpiride had no effect. Comparison of dopamine antagonists at low doses indicated that only domperidone and pimozide caused significant increases in serum concentrations of GtH. Dopamine antagonists potentiated the action of a gonadotrophin-releasing hormone analogue (GnRH-A) with an order of potency of domperidone = pimozide > metoclopramide = fluphenazine. [3H]Domperidone, injected i.p. with unlabelled domperidone, entered the blood and achieved maximum concentrations 12 h after injection, but did not accumulate in the brain in appreciable amounts. Gonadal 3H radioactivity was usually equal to or in excess of blood radioactivity, while [3H]domperidone was highly concentrated in the pituitary in a time-dependent fashion, with maximal accumulation occurring 24 h after injection. The time-course of pituitary accumulation of [3H]domperidone correlated well with the temporal increase in serum GtH levels in response to i.p. injected domperidone or domperidone plus an analogue of LHRH. Domperidone increased serum concentrations of GtH in a dose-related fashion; an analogue of salmon GnRH (sGnRH-A) increased the sensitivity and magnitude of the serum GtH response to domperidone. Serum concentrations of GtH were increased by sGnRH-A in a dose-related fashion; a low dose of domperidone substantially increased the sensitivity of the serum GtH response to sGnRH-A. These results indicate that dopamine inhibits GtH secretion from the goldfish pituitary by acting through a specific mechanism mediated by a dopamine D2 receptor. Domperidone increased serum concentrations of GtH, potentiated the action of gonadotrophin-releasing hormones and did not pass into the brain after i.p. injection into goldfish. The data also suggest that dopamine and GnRH, although acting through different receptors, influence the effect of each other on GtH release. J. Endocr. (1987) 114, 449–458

Evidence of anoxia-induced channel arrest in the brain of the goldfish (Carassius auratus)

2008 ◽  
Vol 148 (4) ◽  
pp. 355-362 ◽  
Author(s):  
Michael P. Wilkie ◽  
Matthew E. Pamenter ◽  
Samir Alkabie ◽  
Dejana Carapic ◽  
Damian S.H. Shin ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
Channel Arrest ◽  
Goldfish Carassius Auratus ◽  
The Brain
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