Immunohistochemical distribution and biological activity of pituitary adenylate cyclase-activating polypeptide (PACAP) in the central nervous system of the frogRana ridibunda

1992 ◽  
Vol 324 (4) ◽  
pp. 485-499 ◽  
Author(s):  
Laurent Yon ◽  
Marc Feuilloley ◽  
Nicolas Chartrel ◽  
Akira Arimura ◽  
J. Michael Conlon ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biological Activity ◽  
Adenylate Cyclase ◽  
Pituitary Adenylate Cyclase ◽  
The Central Nervous System

Regional distributions of pituitary adenylate cyclase activating polypeptide (PACAP) and its binding sites in the rat central nervous system

1992 ◽  
Vol 37 (3) ◽  
pp. 313
Author(s):  
Yoshinori Masuo ◽  
Tetsuya Ohtaki ◽  
Hirokazu Matsumoto ◽  
Yasushi Masuda ◽  
Nobuhiro Suzuki ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adenylate Cyclase ◽  
Binding Sites ◽  
Pituitary Adenylate Cyclase

Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system

1975 ◽  
Vol 88 (1) ◽  
pp. 1-14 ◽  
Author(s):  
I. Kraulis ◽  
G. Foldes ◽  
H. Traikov ◽  
B. Dubrovsky ◽  
M.K. Birmingham
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biological Activity ◽  
The Central Nervous System

EFFECT OF SEROTONIN AND NEUROPEPTIDES ON ADENYLATE CYCLASE OF THE CENTRAL NERVOUS SYSTEM AND PERIPHERAL ORGANS OF THE FRESHWATER SNAIL PLANORBARIUS CORNEUS

1996 ◽  
Vol 28 (4) ◽  
pp. 417-424 ◽  
Author(s):  
MARIA ENRICA FERRETTI ◽  
DARIO SONETTI ◽  
MARIA CRISTINA PARESCHI ◽  
MARCO BUZZI ◽  
MARIA LUISA COLAMUSSI ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adenylate Cyclase ◽  
Freshwater Snail ◽  
Planorbarius Corneus ◽  
Peripheral Organs ◽  
The Central Nervous System

Differential Biological Activity of Estradiol Metabolites

PEDIATRICS ◽  
1978 ◽  
Vol 62 (6) ◽  
pp. 1128-1133
Author(s):  
Jack Fishman ◽  
Charles Martucci
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biological Activity ◽  
Estrogenic Activity ◽  
Critical Role ◽  
Pituitary Hormone ◽  
Clear Cut ◽  
The Central Nervous System ◽  
Estradiol Metabolites ◽  
The One

Assessment of the biological potency of an estrogen in the human has been and remains a formidable task. The problem arises not only from the lack of a readily distinguished physiological endpoint, but also from the diversity of the biological actions of the estrogens. Estrogens exert proliferative effects in recognized target tissues such as endometrium, vagina, and breast,1 and this action is the one commonly associated with the term "estrogenicity." Estrogens, however, also participate in inducing a host of other peripheral responses in tissues such as blood, bone, skin, and others.2 More importantly, the estrogens also exercise major regulatory functions in the central nervous system, including control of pituitary hormone secretion3 and influencing behavior such as food intake4 and sexual receptivity.5 Much attention had been devoted to the design of estrogen structures that would exhibit a specific type of estrogenic activity, such as gonadotropic regulation, without retaining any uterotropic action. Despite the vast numbers of structures synthesized, little clear-cut separation of these activities has been achieved, suggesting that these dual actions of estrogens may be inextricably linked to each other. On the other hand, much effort has also gone into the study of the mechanism of estrogen action in the uterus and in the central nervous system; despite much progress in both directions, little evidence of a commonality between these two responses to estradiol has so far emerged, suggesting that they may not be directly linked. In our studies, we sought to examine whether estradiol metabolism may play a critical role in the expression of the biological activity of the female sex hormone.

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