Astrocytes in cat visual cortex studied by GFAP and S-100 immunocytochemistry during postnatal development

1992 ◽  
Vol 317 (3) ◽  
pp. 309-323 ◽  
Author(s):  
Christian M. Müller
Keyword(s):  
Visual Cortex ◽  
Postnatal Development ◽  
Cat Visual Cortex ◽  
S 100

Postnatal development of perisomatic GABAergic axon terminals on neurons projecting from area 17 to area 18 of the cat visual cortex

1999 ◽  
Vol 16 (1) ◽  
pp. 35-44 ◽  
Author(s):  
FERNANDO PÉREZ-CERDÁ ◽  
LUIS MARTÍNEZ-MILLÁN ◽  
CARLOS MATUTE
Keyword(s):  
Visual Cortex ◽  
Postnatal Development ◽  
Developmental Stages ◽  
Time Frame ◽  
Projection Neurons ◽  
Area 17 ◽  
Gamma Aminobutyric Acid ◽  
Area 18 ◽  
Axon Terminals ◽  
Cat Visual Cortex

We have studied the postnatal development of presumptive axon terminals (puncta) which were recognized by antibodies to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and were located on the somata of area 17 neurons projecting to the ipsilateral area 18 of the visual cortex in cats ranging from 7 days of age to adulthood. Projection neurons were retrogradely labeled by injection of horseradish peroxidase conjugated to wheat germ agglutinin into the ipsilateral area 18. These neurons were mainly pyramidal in shape at all the developmental stages examined and the adult distribution of labeled cells was reached by 21 days. Subsequent GABA postembedding immunohistochemistry using high-resolution light microscopy was carried out to study the development of GABAergic terminals on cell bodies of identified projecting neurons in layers II–III. At all ages examined, we found perisomatic GABAergic puncta on these cells. Their density showed a significant increase from postnatal days 7 to 45, and then remained largely constant through adulthood. Since GABAergic puncta are considered the light-microscopic correlate of GABAergic synaptic terminals, our results support the idea of a developmentally regulated increase in the inhibitory activity of local interneurons on area 17 pyramidal neurons projecting to area 18 in the cat visual cortex which occurs within the same time frame as that of the acquisition of the mature operation of these cells.

The laminar distributions and postnatal development of neurotransmitter and neuromodulator receptors in cat visual cortex

1986 ◽  
Vol 16 (5) ◽  
pp. 661-671 ◽  
Author(s):  
C. Shaw ◽  
M. Wilkinson ◽  
M. Cynader ◽  
M.C. Needler ◽  
C. Aoki ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Postnatal Development ◽  
Cat Visual Cortex

Surgical undercutting prevents receptor redistribution in developing kitten visual cortex

1988 ◽  
Vol 1 (2) ◽  
pp. 205-210 ◽  
Author(s):  
C. Shaw ◽  
G. Prusky ◽  
M. Cynader
Keyword(s):  
Visual Cortex ◽  
Postnatal Development ◽  
Critical Period ◽  
Cortical Plasticity ◽  
Postnatal Life ◽  
Present Communication ◽  
Cat Visual Cortex

AbstractRecent studies have shown that several receptor populations in cat visual cortex undergo alterations in their laminar distributions during postnatal development (Shaw et al., 1984a, b; 1986b). These redistributions occur during the first few months of postnatal life, coincident with the physiologically defined critical period for cortical plasticity. In the present communication, we demonstrate that receptor redistributions can be prevented from occurring, or progressing once started, by surgically isolating the visual cortex at appropriate postnatal ages. These data suggest that the maturation of the chemical circuitry of the visual cortex is dependent on factors of extrinsic origin.

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