Effects of prenatal protein deprivation on postnatal development of granule cells in the fascia dentata

1991 ◽  
Vol 310 (3) ◽  
pp. 356-364 ◽  
Author(s):  
S. Diáz-Cintra ◽  
L. Cintra ◽  
A. Galván ◽  
A. Aguilar ◽  
T. Kemper ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Granule Cells ◽  
Protein Deprivation ◽  
Fascia Dentata

Transient decrease in calbindin immunoreactivity of the rat fascia dentata granule cells after repeated electroconvulsive shocks

Hippocampus ◽  
1994 ◽  
Vol 4 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Niels Tønder ◽  
Jørn Kragh ◽  
Tom Bolwig ◽  
Jens Zimmer
Keyword(s):  
Granule Cells ◽  
Fascia Dentata ◽  
Transient Decrease

Ultrastructural localization of activated NF-κB in granule cells of the rat fascia dentata

Neuroreport ◽  
2000 ◽  
Vol 11 (4) ◽  
pp. 839-844 ◽  
Author(s):  
Barbara Kaltschmidt ◽  
Thomas Deller ◽  
Michael Frotscher ◽  
Christian Kaltschmidt
Keyword(s):  
Granule Cells ◽  
Ultrastructural Localization ◽  
Fascia Dentata

scholarly journals Dendritic Morphology and Inhibitory Regulation Distinguish Dentate Semilunar Granule Cells from Granule Cells through Distinct Stages of Postnatal Development

2019 ◽  
Author(s):  
Akshay Gupta ◽  
Archana Proddutur ◽  
Yun-Juan Chang ◽  
Vidhatri Raturi ◽  
Jenieve Guevarra ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Granule Cells ◽  
Feedback Inhibition ◽  
Input Resistance ◽  
Cell Types ◽  
Structural Features ◽  
Dendritic Morphology ◽  
Membrane Properties ◽  
Projection Neurons ◽  
Inhibitory Regulation

AbstractSemilunar granule cells (SGCs) have been proposed as a morpho-functionally distinct class of hippocampal dentate projection neurons contributing to feedback inhibition and memory processing in juvenile rats. However, the structural and physiological features that can reliably classify granule cells (GCs) from SGCs through postnatal development remain unresolved. Focusing on postnatal days 11-13, 28-42, and >120, corresponding with human infancy, adolescence, and adulthood, we examined the somatodendritic morphology and inhibitory regulation in SGCs and GCs to determine the cell-type specific features. Unsupervised cluster analysis confirmed that morphological features reliably distinguish SGCs from GCs irrespective of animal age. SGCs maintain higher spontaneous inhibitory postsynaptic current (sIPSC) frequency than GCs from infancy through adulthood. Although sIPSC frequency in SGCs was particularly enhanced during adolescence, sIPSC amplitude and cumulative charge transfer declined from infancy to adulthood and were not different between GCs and SGCs. Extrasynaptic GABA current amplitude peaked in adolescence in both cell types and was significantly greater in SGCs than in GCs only during adolescence. Although GC input resistance was higher than in SGCs during infancy and adolescence, input resistance decreased with developmental age in GCs while it progressively increased in SGCs. Consequently, GCs input resistance was significantly lower than SGCs in adults. The data delineate the structural features that can reliably distinguish GCs from SGCs through development. The results reveal developmental differences in passive membrane properties and steady state inhibition between GCs and SGCs which could confound their use in classifying the cell types.

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