An ultrastructural and morphometric study of the effect of removal of retinal input on the development of the dorsal lateral geniculate nucleus

1990 ◽  
Vol 301 (4) ◽  
pp. 585-603 ◽  
Author(s):  
J. K. Brunso-Bechtold ◽  
S. L. Vinsant
Keyword(s):  
Lateral Geniculate Nucleus ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Morphometric Study ◽  
Lateral Geniculate ◽  
Retinal Input ◽  
Dorsal Lateral Geniculate

Neonatal monocular enucleation and the geniculo-cortical system in the golden hamster: Shrinkage in dorsal lateral geniculate nucleus and area 17 and the effects on relay cell size and number

1995 ◽  
Vol 12 (5) ◽  
pp. 971-983 ◽  
Author(s):  
A.J. Trevelyan ◽  
I.D. Thompson
Keyword(s):  
Cell Size ◽  
Lateral Geniculate Nucleus ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Area 17 ◽  
Relay Cell ◽  
Monocular Enucleation ◽  
Lateral Geniculate ◽  
Retinal Input ◽  
Dorsal Lateral Geniculate ◽  
Relay Neurons

AbstractWe have examined the effects of neonatal monocular enucleation on the volume of the dorsal lateral geniculate nucleus (dLGN), the area of area 17, and the size and numbers of geniculate relay neurons identified by retrograde transport of HRP from cortex. Compared to values for normal animals, the only significant change contralateral to the remaining eye was an increase in relay cell radius. The effects ipsilateral to the remaining eye were more widespread: we found significant reductions in the volume of the dLGN (27% reduction), the area of striate cortex (22%), and the number (16%) and average soma radius (6%) of geniculate relay neurons. The relay neurons were also more densely packed, suggesting that other geniculate cell types were affected similarly, although this was not explicitly examined. These changes were not uniform throughout the nucleus, and as such, reflected the changes in retinal input. The greatest reduction in cell size occurred in the region of the ipsilateral dLGN receiving the most sparse retinal input subsequent to enucleation. Nor was the shrinkage of the dLGN uniform, being most apparent in the coronal plane especially along the axis orthogonal to the pia; there appeared to be little change in the anteroposterior extent. Shrinkage in area 17 ipsilateral to the remaining eye was the same (about 22%) whether it was defined by myelin staining or transneuronal transport of WGA-HRP. These results show that the transneuronal changes seen in the organization of visual cortex after early monocular enucleation in rodents are associated with only a moderate loss of geniculate relay cells.

scholarly journals Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Jianlin He ◽  
Xiguang Xu ◽  
Aboozar Monavarfeshani ◽  
Sharmi Banerjee ◽  
Michael A. Fox ◽  
...  
Keyword(s):  
Lateral Geniculate Nucleus ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Lateral Geniculate ◽  
Retinal Input ◽  
Dorsal Lateral Geniculate

scholarly journals Synaptic properties of the feedback connections from the thalamic reticular nucleus to the dorsal lateral geniculate nucleus

2020 ◽  
Vol 124 (2) ◽  
pp. 404-417 ◽  
Author(s):  
Peter W. Campbell ◽  
Gubbi Govindaiah ◽  
Sean P. Masterson ◽  
Martha E. Bickford ◽  
William Guido
Keyword(s):  
Lateral Geniculate Nucleus ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Thalamic Reticular Nucleus ◽  
Reticular Nucleus ◽  
Lateral Geniculate ◽  
Dependent Form ◽  
Dorsal Lateral Geniculate ◽  
Feedback Connections ◽  
Spike Firing ◽  
Stimulation Of

The thalamic reticular nucleus (TRN) modulates thalamocortical transmission through inhibition. In mouse, TRN terminals in the dorsal lateral geniculate nucleus (dLGN) form synapses with relay neurons but not interneurons. Stimulation of TRN terminals in dLGN leads to a frequency-dependent form of inhibition, with higher rates of stimulation leading to a greater suppression of spike firing. Thus, TRN inhibition appears more dynamic than previously recognized, having a graded rather than an all-or-none impact on thalamocortical transmission.

Sign in / Sign up

Export Citation Format

Share Document