Distribution of substance P and vasoactive intestinal polypeptide neurons in the chicken spinal cord, with notes on their postnatal development

1988 ◽  
Vol 278 (2) ◽  
pp. 253-264 ◽  
Author(s):  
Fu Du ◽  
Paul Dubois
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Postnatal Development ◽  
Vasoactive Intestinal Polypeptide ◽  
Intestinal Polypeptide

Vasoactive intestinal polypeptide excitation of central neurons

1978 ◽  
Vol 56 (2) ◽  
pp. 337-340 ◽  
Author(s):  
J. W. Phillis ◽  
J. R. Kirkpatrick ◽  
S. I. Said
Keyword(s):  
Spinal Cord ◽  
Cerebral Cortex ◽  
Substance P ◽  
Vasoactive Intestinal Polypeptide ◽  
Cortical Neurons ◽  
Dorsal Root ◽  
Central Neurons ◽  
Sensory Motor ◽  
Repeated Applications ◽  
Intestinal Polypeptide

Vasoactive intestinal polypeptide (VIP) was tested on neurons in the rat sensory motor cerebral cortex and on the isolated hemisected toad spinal cord. Iontophoretically applied VIP excited deep, spontaneously active cortical neurons, including identified corticospinal neurons. The excitation had a latency of onset varying from several seconds to over 1 min and often lasted for a minute or longer after cessation of the application. Desensitization of the effect occurred with repeated applications. VIP caused a depolarization of motoneurons and dorsal root terminals in the isolated amphibian spinal cord. Threshold for this effect was about 10−6 M. The effects of VIP on both preparations were comparable with those of another peptide, substance P.

scholarly journals Bombesin-Like, Substance P and Vasoactive Intestinal Polypeptide Receptors in Fetal Cortical Homografts to Host Cortex and Spinal Cord

1989 ◽  
Vol 1 (3-4) ◽  
pp. 105-112 ◽  
Author(s):  
Terry W. Moody ◽  
Reina L. Getz ◽  
William J. Goldberg ◽  
Jerald J. Bernstein
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Substance P ◽  
Vasoactive Intestinal Polypeptide ◽  
Peptide Receptors ◽  
Adult Rat ◽  
Graft Donor ◽  
Intestinal Polypeptide

Neuropeptide receptors were visualized in homografts of fetal cortex (E14) into adult rat cortex (immediate or 7 day delay) and spinal cord usingin vitroautoradiographic techniques to explore the expression of peptide receptors in the same graft tissue in different central nervous system implantation sites. Receptors for bombesin (BN)-like peptides developed in the grafts by 3 weeks postimplantation regardless of location or age of implantation pocket in host. After 4 weeks, the density of BN receptors was confined to the graft. In grafts to spinal cord, however, high densities of BN-like receptors were not confined to the graft but were distributed throughout the spinal cord. In contrast, the density of vasoactive intestinal polypeptide (VIP) and substance P (SP) receptors was moderate and low to undetectable in the fetal grafts. The development of the peptide receptors studied was graft donor tissue specific since they were not altered by central nervous system implantation site.

Survey of distribution of substance P, vasoactive intestinal polypeptide, cholecystokinin, neurotensin, Met-enkephalin, bombesin and PHI in the spinal cord of cat, dog, sloth and monkey

Peptides ◽  
1988 ◽  
Vol 9 (2) ◽  
pp. 357-372 ◽  
Author(s):  
Tony L. Yaksh ◽  
Sandra R. Michener ◽  
Jane E. Bailey ◽  
Gail J. Harty ◽  
Darlene L. Lucas ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Vasoactive Intestinal Polypeptide ◽  
Intestinal Polypeptide

scholarly journals Innervation of the pancreas by substance P, enkephalin, vasoactive intestinal polypeptide and gastrin/CCK immunoractive nerves.

1979 ◽  
Vol 27 (9) ◽  
pp. 1283-1284 ◽  
Author(s):  
L I Larsson
Keyword(s):  
Blood Flow ◽  
Insulin Secretion ◽  
Substance P ◽  
Blood Vessels ◽  
Vasoactive Intestinal Polypeptide ◽  
Pancreatic Blood Flow ◽  
Major Site ◽  
Site Of Action ◽  
Immunocytochemical Studies ◽  
Intestinal Polypeptide

Immunocytochemical studies habe shown that many peptides which profoundly affect the endocrine and exocrine functions of the pancreas are localized to neurons. In the cat, such peptidergic nerves appear to innervate ganglia, islets and blood vessels of the pancreas, whereas their contributions to exocrine cells are minor. Our studies suggest that pancreatic ganglia represent one major site of action of the peptides and that, in addition, nerves containing the vasoactive intestinal polypeptide and gastrin/CCK-related peptides profoundly affect pancreatic blood flow and insulin secretion, respectively.

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