Myeloarchitectonics of the lateral olfactory tract and of the piriform cortex of the albino rat

1949 ◽  
Vol 91 (1) ◽  
pp. 103-127 ◽  
Author(s):  
Jerzy Kreiner
Keyword(s):  
Piriform Cortex ◽  
Lateral Olfactory Tract ◽  
Albino Rat ◽  
Olfactory Tract

scholarly journals Effects of lateral olfactory tract stimulation on Fos immunoreactivity in vasopressin neurones of the rat piriform cortex

2017 ◽  
Vol 29 (11) ◽  
pp. e12531 ◽  
Author(s):  
C. Tsuji ◽  
T. Tsuji ◽  
A. Allchorne ◽  
G. Leng ◽  
M. Ludwig
Keyword(s):  
Piriform Cortex ◽  
Lateral Olfactory Tract ◽  
Olfactory Tract

scholarly journals NOTE: Effects of lateral olfactory tract stimulation on Fos immunoreactivity in vasopressin neurones of the rat piriform cortex

2018 ◽  
Vol 30 (8) ◽  
pp. e12637
Author(s):  
C. Tsuji ◽  
T. Tsuji ◽  
A. Allchorne ◽  
G. Leng ◽  
M. Ludwig
Keyword(s):  
Piriform Cortex ◽  
Lateral Olfactory Tract ◽  
Olfactory Tract

scholarly journals Bi-directional encoding of context-based odors and behavioral states by the nucleus of the lateral olfactory tract

iScience ◽  
2021 ◽  
pp. 102381
Author(s):  
Yuta Tanisumi ◽  
Kazuki Shiotani ◽  
Junya Hirokawa ◽  
Yoshio Sakurai ◽  
Hiroyuki Manabe
Keyword(s):  
Lateral Olfactory Tract ◽  
Olfactory Tract ◽  
Behavioral States

scholarly journals Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala

2021 ◽  
Vol 226 (2) ◽  
pp. 519-562 ◽  
Author(s):  
Elena Garcia-Calero ◽  
Lara López-González ◽  
Margaret Martínez-de-la-Torre ◽  
Chen-Ming Fan ◽  
Luis Puelles
Keyword(s):  
Experimental Data ◽  
Mouse Line ◽  
Lateral Olfactory Tract ◽  
Migration Stream ◽  
Olfactory Tract ◽  
Basolateral Nucleus ◽  
Gene Functions ◽  
Layer 2 ◽  
Embryonic Origin ◽  
Olfactory Input

AbstractWe focus this report on the nucleus of the lateral olfactory tract (NLOT), a superficial amygdalar nucleus receiving olfactory input. Mixed with its Tbr1-expressing layer 2 pyramidal cell population (NLOT2), there are Sim1-expressing cells whose embryonic origin and mode of arrival remain unclear. We examined this population with Sim1-ISH and a Sim1-tauLacZ mouse line. An alar hypothalamic origin is apparent at the paraventricular area, which expresses Sim1 precociously. This progenitor area shows at E10.5 a Sim1-expressing dorsal prolongation that crosses the telencephalic stalk and follows the terminal sulcus, reaching the caudomedial end of the pallial amygdala. We conceive this Sim1-expressing hypothalamo-amygdalar corridor (HyA) as an evaginated part of the hypothalamic paraventricular area, which participates in the production of Sim1-expressing cells. From E13.5 onwards, Sim1-expressing cells migrated via the HyA penetrate the posterior pallial amygdalar radial unit and associate therein to the incipient Tbr1-expressing migration stream which swings medially past the amygdalar anterior basolateral nucleus (E15.5), crosses the pallio-subpallial boundary (E16.5), and forms the NLOT2 within the anterior amygdala by E17.5. We conclude that the Tbr1-expressing NLOT2 cells arise strictly within the posterior pallial amygdalar unit, involving a variety of required gene functions we discuss. Our results are consistent with the experimental data on NLOT2 origin reported by Remedios et al. (Nat Neurosci 10:1141–1150, 2007), but we disagree on their implication in this process of the dorsal pallium, observed to be distant from the amygdala.

scholarly journals SAT-606 Distribution of Beta Klotho Gene Expression in the Mouse Brain

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Bianca S Bono ◽  
Persephone A Miller ◽  
Nikita K Koziel Ly ◽  
Melissa J Chee
Keyword(s):  
Basolateral Amygdala ◽  
Piriform Cortex ◽  
Brain Regions ◽  
Brain Atlas ◽  
Hypothalamic Nucleus ◽  
Fibroblast Growth Factor 21 ◽  
Lateral Olfactory Tract ◽  
Hypothalamic Area ◽  
Low Levels ◽  
The Brain

Abstract Fibroblast growth factor 21 (FGF21) has emerged as a critical endocrine factor for understanding the neurobiology of obesity, such as by the regulation thermogenesis, food preference, and metabolism, as well as for neuroprotection in Alzheimer’s disease and traumatic brain injury. FGF21 is synthesized primarily by the liver and pancreas then crosses the blood brain barrier to exert its effects in the brain. However, the sites of FGF21 action in the brain is not well-defined. FGF21 action requires the activation of FGF receptor 1c as well as its obligate co-receptor beta klotho (KLB). In order to determine the sites of FGF21 action, we mapped the distribution of Klb mRNA by in situ hybridization using RNAscope technology. We labeled Klb distribution throughout the rostrocaudal axis of male wildtype mice by amplifying Klb hybridization using tyramine signal amplification and visualizing Klb hybridization using Cyanine 3 fluorescence. The resulting Klb signal appears as punctate red “dots,” and each Klb neuron may express low (1–4 dots), medium (5–9 dots), or high levels (10+ dots) of Klb hybridization. We then mapped individual Klb expressing neuron to the atlas plates provided by the Allen Brain Atlas in order to determine Klb distribution within the substructures of each brain region, which are defined by Nissl-based parcellations of cytoarchitectural boundaries. The distribution of Klb mRNA is widespread throughout the brain, and the brain regions analyzed thus far point to notable expression in the hypothalamus, amygdala, hippocampus, and the cerebral cortex. The highest expression of Klb was localized to the suprachiasmatic nucleus in the hypothalamus, which contained low and medium Klb-expressing neurons in the lateral hypothalamic area and ventromedial hypothalamic nucleus while low expressing Klb neurons were seen in the paraventricular and dorsmedial hypothalamic nucleus. Hippocampal Klb expression was limited to the dorsal region and largely restricted to the pyramidal cell layer of the dentate gyrus, CA3, CA2, and CA1 but at low levels only. In the amygdala, low and medium Klb expressing cells were seen in lateral amygdala nucleus while low levels were observed in the basolateral amygdala nucleus. Cortical Klb expression analyzed thus far included low Klb-expressing neurons in the olfactory areas, including layers 2 and 3 of piriform cortex and nucleus of the lateral olfactory tract. These findings are consistent with the known roles of FGF21 in the central regulation of energy balance, but also implicates potentially wide-ranging effects of FGF21 such as in executive functions.

Chronic stress leads to long-lasting deficits in olfactory-guided behaviors, and to neuroplastic changes in the nucleus of the lateral olfactory tract

2018 ◽  
Vol 98 ◽  
pp. 130-144 ◽  
Author(s):  
Ricardo P. Vaz ◽  
Armando Cardoso ◽  
Paula Serrão ◽  
Pedro A. Pereira ◽  
M. Dulce Madeira
Keyword(s):  
Chronic Stress ◽  
Lateral Olfactory Tract ◽  
Olfactory Tract
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