scholarly journals Metabolic activity of the nervous system. I. Amount of non-protein nitrogen in the central nervous system of the normal albino rat

1917 ◽  
Vol 28 (2) ◽  
pp. 361-378 ◽  
Author(s):  
S. Hatai
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Metabolic Activity ◽  
Albino Rat ◽  
Protein Nitrogen ◽  
The Central Nervous System

Effects of Certain Indole Amines on Electrical Activity of the Nervous System

1956 ◽  
Vol 185 (3) ◽  
pp. 601-606 ◽  
Author(s):  
Alan G. Slocombe ◽  
Hudson Hoagland ◽  
Lillian S. Tozian
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Electrical Activity ◽  
Lysergic Acid ◽  
Subcortical Structures ◽  
Albino Rat ◽  
Site Of Action ◽  
The Central Nervous System ◽  
Recovery From Anesthesia ◽  
The Brain

Lysergic acid diethylamide (LSD), 5-hydroxytryptamine, and adrenochrome were shown to have properties similar to epinephrine in their effects on the spontaneous electrical activity in the brain of the albino rat. The effects of these drugs were shown to be determined by the type of anesthetic used. In Pentothal-anesthetized animals, profound reduction of the electrical activity in both frequency and amplitude was found in response to these drugs, while in ether-anesthetized animals there was no significant effect. There was a tendency for LSD to increase electrical activity when injected following recovery from anesthesia. The significance of this differential response is discussed with respect to structures in the central nervous system primarily affected by ether and Pentothal, and it is suggested that the site of action of these compounds is in Pentothal-sensitive nonspecific pathways. The site of the depressive action of these drugs with Pentothal is further defined by the fact that both cortical and subcortical structures were equally affected, while respiratory and cardio-regulatory centers were not significantly depressed. This implicates one of the lower nonspecific centers with widespread cortical and subcortical projections.

Über die gerichtete Aufnahme des Biopterins im Organismus I.

1968 ◽  
Vol 23 (5) ◽  
pp. 666-670 ◽  
Author(s):  
Gisela Hanser ◽  
Heinz Rembold
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Metabolic Activity ◽  
Phenylalanine Hydroxylase ◽  
Tracheal Epithelium ◽  
Cellular Activity ◽  
Functional Importance ◽  
Larval Stages ◽  
The Central Nervous System ◽  
High Metabolic Activity

C14 labelled Biopterin and Neopterin, when fed to larval stages of Queen and Worker bees, behave similarly and are incorporated into different organs. During metamorphosis and imaginal development, the accumulation of the radioactive pterins is found in places of high metabolic activity such as the eyes, wings, legs. They are also found in the tracheal epithelium, in the wing muscles and the ovaries. In tissues of high cellular activity the radioactivity is found in the nuclei. The concentration of the administered labelled Biopterin and Neopterin into the imaginal cuticle at the time of sclerotization and pigmentation, as well as their directed uptake by the peripheral ganglion sheath of the central nervous system points to the functional importance of these pterins as cofactors of phenylalanine hydroxylase and respectively of tryptophane hydroxylase in insects.

Increased hexokinase activity in forebrain of water-deprived and diabetes insipidus rats

1986 ◽  
Vol 251 (2) ◽  
pp. R268-R273
Author(s):  
T. L. Krukoff ◽  
W. E. Turton ◽  
F. R. Calaresu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diabetes Insipidus ◽  
Metabolic Activity ◽  
Body Fluid ◽  
Supraoptic Nucleus ◽  
Preoptic Area ◽  
Fluid Regulation ◽  
The Central Nervous System ◽  
Body Fluid Regulation

Metabolic studies using the 2-[14C]deoxy-D-glucose and cytochrome oxidase techniques have demonstrated changes in the activity of central sites associated with the hypothalamoneurohypophysial system in water-deprived (WD) and diabetes insipidus (DI) rats. Another method that may be used as an index of metabolic activity in discrete regions of the central nervous system is the measurement of hexokinase (HK) activity. This study describes changes in metabolic activity, as measured by HK histochemistry, in regions of the forebrain of WD and DI rats. Significant increases in HK activity measured by densitometric analysis were observed in the magnocellular component of the paraventricular nucleus of the hypothalamus, supraoptic nucleus, nucleus circularis, and neurohypophysis of WD and DI rats. In addition, increased HK activity was observed in the preoptic area and subfornical organ of DI rats. These data demonstrate that metabolic changes occur in the forebrain of WD and DI rats within structures involved in body fluid regulation. The present study also demonstrates that HK histochemistry may be used as a marker of metabolic activity in discrete regions of the central nervous system.

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