The organization of cholinergic projections in the visual thalamus of the mouse

2021 ◽  
Author(s):  
Guela Sokhadze ◽  
Kyle L. Whyland ◽  
Martha E. Bickford ◽  
William Guido
Keyword(s):  
Visual Thalamus ◽  
Cholinergic Projections

Cholinergic projections to the visual thalamus and superior colliculus

1999 ◽  
Vol 847 (1) ◽  
pp. 121-123 ◽  
Author(s):  
Sara Billet ◽  
Nell B. Cant ◽  
William C. Hall
Keyword(s):  
Superior Colliculus ◽  
Visual Thalamus ◽  
Cholinergic Projections

scholarly journals Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Li Cheng ◽  
Cenglin Xu ◽  
Lu Wang ◽  
Dadao An ◽  
Lei Jiang ◽  
...  
Keyword(s):  
Functional Outcomes ◽  
Negative Symptoms ◽  
Cholinergic Neurons ◽  
Sensorimotor Gating ◽  
Social Impairment ◽  
H1 Receptor ◽  
Behavioral Deficits ◽  
Social Impairments ◽  
Cholinergic Projections ◽  
Functional Deficiency

AbstractNegative symptoms in schizophrenia strongly contribute to poor functional outcomes, however its pathogenesis is still unclear. Here, we found that histamine H1 receptor (H1R) expression in basal forebrain (BF) cholinergic neurons was decreased in patients with schizophrenia having negative symptoms. Deletion of H1R gene in cholinergic neurons in mice resulted in functional deficiency of cholinergic projections from the BF to the prefrontal cortex and in the formation of sensorimotor gating deficit, social impairment and anhedonia-like behavior. These behavioral deficits can be rescued by re-expressing H1R or by chemogenetic activation of cholinergic neurons in the BF. Direct chemogenetic inhibition of BF cholinergic neurons produced such behavioral deficits and also increased the susceptibility to hyperlocomotion. Our results suggest that the H1R deficiency in BF cholinergic neurons is critical for sensorimotor gating deficit, social impairments and anhedonia-like behavior. This finding may help to understand the genetic and biochemical bases of negative symptoms in schizophrenia.

Cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei to the pontine gigantocellular tegmental field in the cat

1988 ◽  
Vol 451 (1-2) ◽  
pp. 397-402 ◽  
Author(s):  
Akira Mitani ◽  
Keihachiro Ito ◽  
Ann E. Hallanger ◽  
Bruce H. Wainer ◽  
Kiyoshi Kataoka ◽  
...  
Keyword(s):  
Tegmental Nuclei ◽  
Cholinergic Projections

Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance

2004 ◽  
Vol 124 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Heidi S. Phillips ◽  
Merry Nishimura ◽  
Mark P. Armanini ◽  
Karen Chen ◽  
Kathryn M. Albers ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Target Innervation ◽  
Deficient Mice ◽  
Cholinergic Projections

Substance P containing and cholinergic projections from the habenula

1978 ◽  
Vol 149 (2) ◽  
pp. 413-429 ◽  
Author(s):  
A. Claudio Cuello ◽  
Piers C. Emson ◽  
George Paxinos ◽  
Thomas Jessell
Keyword(s):  
Substance P ◽  
Cholinergic Projections

Feed-forward inhibition in the visual thalamus

2002 ◽  
Vol 44-46 ◽  
pp. 479-487 ◽  
Author(s):  
Efstratios K Kosmidis ◽  
Jean-François Vibert
Keyword(s):  
Feed Forward ◽  
Visual Thalamus ◽  
Feed Forward Inhibition
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