Mapping Reward Mechanisms by Intracerebral Self Stimulation in the Rhesus Monkey ( Macaca mulatta )

2021 ◽  
Author(s):  
Douglas Mc Hose Bowden ◽  
Dwight Charles German
Keyword(s):  
Rhesus Monkey ◽  
Macaca Mulatta ◽  
Reward Mechanisms ◽  
Self Stimulation

scholarly journals Rhesus monkey (Macaca mulatta) cool sensitivity measured by a signal detection method

1976 ◽  
Vol 19 (3) ◽  
pp. 246-251 ◽  
Author(s):  
Helen H. Molinari ◽  
Andrew J. Rózsa ◽  
Dan R. Kenshalo
Keyword(s):  
Rhesus Monkey ◽  
Signal Detection ◽  
Macaca Mulatta ◽  
Detection Method

scholarly journals Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model

2021 ◽  
Vol 59 (1) ◽  
pp. 175-182
Author(s):  
Dong-hong Tang ◽  
Chen-yun Wang ◽  
Xi Huang ◽  
Hong-kun Yi ◽  
Zhe-li Li ◽  
...  
Keyword(s):  
Animal Model ◽  
Rhesus Monkey ◽  
Macaca Mulatta

scholarly journals Recommendations for Abnormal Behaviour Ethograms in Monkey Research

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1461
Author(s):  
Andrea Polanco ◽  
Brenda McCowan ◽  
Lee Niel ◽  
David L. Pearl ◽  
Georgia Mason
Keyword(s):  
Macaca Mulatta ◽  
Regression Models ◽  
Convergent Validity ◽  
P Value ◽  
Morphological Similarity ◽  
Abnormal Behaviour ◽  
Logistic Regression Models ◽  
The Third ◽  
Welfare Implications ◽  
Self Stimulation

Laboratory monkey ethograms currently include subcategories of abnormal behaviours that are based on superficial morphological similarity. Yet, such ethograms may be misclassifying behaviour, with potential welfare implications as different abnormal behaviours are likely to have distinct risk factors and treatments. We therefore investigated the convergent validity of four hypothesized subcategories of abnormal behaviours (‘motor’, e.g., pacing; ‘self-stimulation’, e.g., self-sucking; ‘postural’, e.g., hanging; and ‘self-abuse’, e.g., self-biting). This hypothesis predicts positive relationships between the behaviours within each subcategory. Rhesus macaque (Macaca mulatta) data on 19 abnormal behaviours were obtained from indoor-housed animals (n = 1183). Logistic regression models, controlling for sex, age, and the number of observations, revealed that only 1/6 ‘motor’ behaviours positively predicted pacing, while 2/3 ‘self-abuse’ behaviours positively predicted self-biting (one-tailed p-value < 0.05). Furthermore, ‘self-stimulation’ behaviours did not predict self-sucking, and none of the ‘postural’ behaviours predicted hanging. Thus, none of the subcategories fully met convergent validity. Subsequently, we created four new valid subcategories formed of comorbid behaviours. The first consisted of self-biting, self-hitting, self-injurious behaviour, floating limb, leg-lifting, and self-clasping. The second comprised twirling, bouncing, rocking, swinging, and hanging. The third comprised pacing and head-twisting, while the final subcategory consisted of flipping and eye-poking. Self-sucking, hair-plucking, threat-biting, and withdrawn remained as individual behaviours. We encourage laboratories to replicate the validation of these subcategories first, and for scientists working with other species to validate their ethograms before using them in welfare assessments.

Accuracy of the regulation of caloric ingestion in the rhesus monkey

1978 ◽  
Vol 235 (1) ◽  
pp. R29-R34 ◽  
Author(s):  
P. R. McHugh ◽  
T. H. Moran
Keyword(s):  
Rhesus Monkey ◽  
Macaca Mulatta ◽  
Caloric Intake ◽  
Feeding Period ◽  
Random Fashion ◽  
Series Of Experiments

In seven male monkeys, Macaca mulatta, the infusion of nutrients into the stomach just prior to or 20 h before a 4-h feeding period reduced the feeding by an amount comparable to the calories infused. Pure carbohydrates, fat, protein, and mixtures were employed as infusions and given in a random fashion over a caloric range of 75-300 kcal. In a second series of experiments, monkeys were partially fasted on 1 day and in this way deprived of 75, 150, 300, or 450 kcal. On successive days, they overate to compensate for this deprivation. The smaller deprivations (75 and 150 kcal) were corrected on the first recovery day. The 300-kcal deprivation required 2 days to be corrected while the 450-kcal deficit was only partially restored. These experiments demonstrate the capacities of the monkey to respond with precision to caloric supply and deprivation so as to maintain a constant caloric intake.

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