Development of parvalbumin neurons and perineuronal nets in the visual cortex of normal and dark‐exposed cats

2021 ◽  
Author(s):  
Elise M. Aronitz ◽  
Braden A. Kamermans ◽  
Kevin R. Duffy
Keyword(s):  
Visual Cortex ◽  
Perineuronal Nets ◽  
Parvalbumin Neurons

scholarly journals Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex

2021 ◽  
Author(s):  
John H. Harkness ◽  
Angela E. Gonzalez ◽  
Priyanka N. Bushana ◽  
Emily T. Jorgensen ◽  
Deborah M. Hegarty ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Perineuronal Nets ◽  
Diurnal Changes ◽  
Parvalbumin Neurons

scholarly journals Dopamine Receptor Expression Among Local and Visual Cortex-Projecting Frontal Eye Field Neurons

2019 ◽  
Vol 30 (1) ◽  
pp. 148-164 ◽  
Author(s):  
Adrienne Mueller ◽  
Rebecca M Krock ◽  
Steven Shepard ◽  
Tirin Moore
Keyword(s):  
Visual Cortex ◽  
Pyramidal Neurons ◽  
Receptor Expression ◽  
Inhibitory Neurons ◽  
Extrastriate Cortex ◽  
Frontal Eye Field ◽  
D2 Dopamine Receptors ◽  
Dopaminergic Modulation ◽  
Eye Field ◽  
Parvalbumin Neurons

Abstract Dopaminergic modulation of prefrontal cortex plays an important role in numerous cognitive processes, including attention. The frontal eye field (FEF) is modulated by dopamine and has an established role in visual attention, yet the underlying circuitry upon which dopamine acts is not known. We compared the expression of D1 and D2 dopamine receptors (D1Rs and D2Rs) across different classes of FEF neurons, including those projecting to dorsal or ventral extrastriate cortex. First, we found that both D1Rs and D2Rs are more prevalent on pyramidal neurons than on several classes of interneurons and are particularly prevalent on putatively long-range projecting pyramidals. Second, higher proportions of pyramidal neurons express D1Rs than D2Rs. Third, overall a higher proportion of inhibitory neurons expresses D2Rs than D1Rs. Fourth, among inhibitory interneurons, a significantly higher proportion of parvalbumin+ neurons expresses D2Rs than D1Rs, and a significantly higher proportion of calbindin+ neurons expresses D1Rs than D2Rs. Finally, compared with D2Rs, virtually all of the neurons with identified projections to both dorsal and ventral extrastriate visual cortex expressed D1Rs. Our results demonstrate that dopamine tends to act directly on the output of the FEF and that dopaminergic modulation of top-down projections to visual cortex is achieved predominately via D1Rs.

Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex

2018 ◽  
Vol 112 ◽  
pp. 59-70 ◽  
Author(s):  
Hiroshi Ueno ◽  
Keizo Takao ◽  
Shunsuke Suemitsu ◽  
Shinji Murakami ◽  
Naoya Kitamura ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Perineuronal Nets ◽  
Mouse Cerebral Cortex ◽  
Age Dependent ◽  
Specific Alteration ◽  
Parvalbumin Neurons

scholarly journals Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex

2012 ◽  
Vol 32 (27) ◽  
pp. 9429-9437 ◽  
Author(s):  
M. Beurdeley ◽  
J. Spatazza ◽  
H. H. C. Lee ◽  
S. Sugiyama ◽  
C. Bernard ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Perineuronal Nets

scholarly journals Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons

2020 ◽  
Author(s):  
Angelina Lesnikova ◽  
Plinio Cabrera Casarotto ◽  
Senem Merve Fred ◽  
Mikko Voipio ◽  
Frederike Winkel ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Protein Tyrosine Phosphatase ◽  
Critical Period ◽  
Antidepressant Treatment ◽  
Tyrosine Phosphatase ◽  
Adult Brain ◽  
Neurotrophin Receptor ◽  
Perineuronal Nets ◽  
Protein Tyrosine ◽  
Chondroitin Sulphate Proteoglycans

AbstractPerineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulphate proteoglycans (CSPGs) which preferentially encase parvalbumin-containing (PV+) interneurons. PNNs restrict cortical network plasticity but the molecular mechanisms involved are unclear. We found that reactivation of ocular dominance plasticity in the adult visual cortex induced by chondroitinase (chABC)-mediated PNN removal requires intact signaling by the neurotrophin receptor TRKB in PV+ neurons. Additionally, we demonstrate that chABC increases TRKB phosphorylation (pTRKB), while PNN component aggrecan attenuates BDNF-induced pTRKB in cortical neurons in culture. We further found that protein tyrosine phosphatase sigma (PTPσ, PTPRS), receptor for CSPGs, interacts with TRKB and restricts TRKB phosphorylation. PTPσ deletion increases phosphorylation of TRKB in vitro and in vivo in male and female mice, and juvenile-like plasticity is retained in the visual cortex of adult PTPσ deficient mice (PTPσ+/-). The antidepressant drug fluoxetine, which is known to promote TRKB phosphorylation and reopen critical period-like plasticity in the adult brain, disrupts the interaction between TRKB and PTPσ by binding to the transmembrane domain of TRKB. We propose that both chABC and fluoxetine reopen critical period-like plasticity in the adult visual cortex by promoting TRKB signaling in PV+ neurons through inhibition of TRKB dephosphorylation by the PTPσ-CSPG complex.Significance statementCritical period-like plasticity can be reactivated in the adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or by chronic antidepressant treatment. We now show that the effects of both chondroitinase and fluoxetine are mediated by the neurotrophin receptor TRKB in parvalbumin-containing (PV+) interneurons. We found that chondroitinase-induced visual cortical plasticity is dependent on TRKB in PV+ neurons. Protein tyrosine phosphatase type S (PTPσ, PTPRS), a receptor for PNNs, interacts with TRKB and inhibits its phosphorylation, and chondroitinase treatment or deletion of PTPσ increases TRKB phosphorylation. Antidepressant fluoxetine disrupts the interaction between TRKB and PTPσ, thereby increasing TRKB phosphorylation. Thus, juvenile-like plasticity induced by both chondroitinase and antidepressant treatment is mediated by TRKB activation in PV+ interneurons.

scholarly journals Reduced Responsiveness to Long-Term Monocular Deprivation of Parvalbumin Neurons Assessed by c-Fos Staining in Rat Visual Cortex

PLoS ONE ◽  
2009 ◽  
Vol 4 (2) ◽  
pp. e4342 ◽  
Author(s):  
Marco Mainardi ◽  
Silvia Landi ◽  
Nicoletta Berardi ◽  
Lamberto Maffei ◽  
Tommaso Pizzorusso
Keyword(s):  
Visual Cortex ◽  
Monocular Deprivation ◽  
Parvalbumin Neurons

scholarly journals Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia

2016 ◽  
Vol 41 (9) ◽  
pp. 2206-2214 ◽  
Author(s):  
John F Enwright ◽  
Sowmya Sanapala ◽  
Aaron Foglio ◽  
Raissa Berry ◽  
Kenneth N Fish ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Perineuronal Nets ◽  
Dorsolateral Prefrontal ◽  
Parvalbumin Neurons

scholarly journals Differential Expression and Cell-Type Specificity of Perineuronal Nets in Hippocampus, Medial Entorhinal Cortex, and Visual Cortex Examined in the Rat and Mouse

eNeuro ◽  
2017 ◽  
Vol 4 (3) ◽  
pp. ENEURO.0379-16.2017 ◽  
Author(s):  
Kristian Kinden Lensjø ◽  
Ane Charlotte Christensen ◽  
Simen Tennøe ◽  
Marianne Fyhn ◽  
Torkel Hafting
Keyword(s):  
Visual Cortex ◽  
Differential Expression ◽  
Entorhinal Cortex ◽  
Perineuronal Nets ◽  
Cell Type ◽  
Cell Type Specificity ◽  
Medial Entorhinal Cortex
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