Serotonin distribution in the brain of the plainfin midshipman: Substrates for vocal‐acoustic modulation and a reevaluation of the serotonergic system in teleost fishes

2020 ◽  
Vol 528 (18) ◽  
pp. 3451-3478
Author(s):  
Miky Timothy ◽  
Paul M. Forlano
Keyword(s):  
Serotonergic System ◽  
Teleost Fishes ◽  
Acoustic Modulation ◽  
Plainfin Midshipman ◽  
The Brain

The role of tryptophan in hepatic encephalopathy

1993 ◽  
Vol 5 (4) ◽  
pp. 71-75
Author(s):  
C. Aaldijk ◽  
W.W. Van Den Broek ◽  
R.C. Van Der Mast
Keyword(s):  
Hepatic Encephalopathy ◽  
Clinical Picture ◽  
Serotonergic System ◽  
Pathogenetic Mechanisms ◽  
Research Findings ◽  
Glutamine Synthesis ◽  
The Brain ◽  
Tryptophan Uptake

SummaryIn this review the most important hypotheses for the occurrence of the clinical picture of hepatic encephalopathy are discussed. As possible pathogenetic mechanisms are raised: dysfunction of the serotonergic system due to an increased tryptophan uptake in the brain, an elevated intracerebral ammoniac concentration and glutamine synthesis, and a heightened intracerebral GABA-activity.The dysregulation of the serotonergic system as a consequence of the increased intracerebral tryptophan uptake is described as one of the most important pathogenetic mechanisms. The elevated intracerebral ammoniac concentration and the elevated intracerebral glutamine synthesis play in this a facilitating role. The similarity in symptomatology of the clinical picture of HE and the serotonergic syndrome support this hypothesis. Due to contradictory research findings the role of the GABA-ergic system and the occurrence of HE remains unclear.

Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice

2014 ◽  
Vol 40 ◽  
pp. 37-47 ◽  
Author(s):  
Tsuyoshi Otsuka ◽  
Misato Kawai ◽  
Yuki Togo ◽  
Ryosei Goda ◽  
Takahiro Kawase ◽  
...  
Keyword(s):  
Serotonergic System ◽  
Laboratory Mice ◽  
Photoperiodic Responses ◽  
The Brain ◽  
Peripheral Metabolism

Neurotrophic factors (BDNF and GDNF) and the serotonergic system of the brain

2017 ◽  
Vol 82 (3) ◽  
pp. 308-317 ◽  
Author(s):  
N. K. Popova ◽  
T. V. Ilchibaeva ◽  
V. S. Naumenko
Keyword(s):  
Neurotrophic Factors ◽  
Serotonergic System ◽  
The Brain

scholarly journals Affective spectrum disorders and role of serotonergic system of the brain

2014 ◽  
Vol 1 (3) ◽  
pp. 168-173
Author(s):  
Ivana Timotijevic ◽  
Mirjana Todorovic ◽  
Katarina Crnic ◽  
Srdjan Markovic ◽  
Dragana Kastratovic
Keyword(s):  
Serotonergic System ◽  
Spectrum Disorders ◽  
The Brain

scholarly journals Neuroanatomical Distribution of the Serotonergic System in the Brain and Retina of Holostean Fishes, The Sister Group to Teleosts

2020 ◽  
Vol 95 (1) ◽  
pp. 25-44
Author(s):  
Daniel Lozano ◽  
Agustín González ◽  
Jesús M. López
Keyword(s):  
Spinal Cord ◽  
Preoptic Area ◽  
Area Postrema ◽  
Sister Group ◽  
Brain Regions ◽  
Serotonergic System ◽  
Paraventricular Organ ◽  
Cell Groups ◽  
Actinopterygian Fishes ◽  
The Brain

Among actinopterygian fishes, holosteans are the phylogenetically closest group to teleosts but they have been much less studied, particularly regarding the neurochemical features of their central nervous system. The serotonergic system is one of the most important and conserved systems of neurotransmission in all vertebrates. By means of immunohistochemistry against serotonin (5-hydroxytryptamine), we have conducted a comprehensive and complete description of this system in the brain and retina of representative species of the 3 genera of holostean fishes, belonging to the only 2 extant orders, Amiiformes and Lepisosteiformes. Serotonin-immunoreactive cell groups were detected in the preoptic area, the hypothalamic paraventricular organ, the epiphysis, the pretectal region, the long and continuous column of the raphe, the spinal cord, and the inner nuclear layer of the retina. Specifically, the serotonergic cell groups in the preoptic area, the epiphysis, the pretectum, and the retina had never been identified in previous studies in this group of fishes. Widespread serotonergic innervation was observed in all main brain regions, but more abundantly in the subpallium, the hypothalamus, the habenula, the optic tectum, the so-called cerebellar nucleus, and the area postrema. The comparative analysis of these results with those in other groups of vertebrates reveals some extremely conserved features, such as the presence of serotonergic cells in the retina, the pineal organ, and the raphe column, while other characteristics, like the serotonergic populations in the preoptic area, the paraventricular organ, the pretectum, and the spinal cord are generally present in all fish groups, but have been lost in most amniotes.

Nuclear organization of the serotonergic system in the brain of the rock cavy (Kerodon rupestris)

2012 ◽  
Vol 43 (2) ◽  
pp. 112-119 ◽  
Author(s):  
Joacil G. Soares ◽  
José R.L.P. Cavalcanti ◽  
Francisco G. Oliveira ◽  
André L.B. Pontes ◽  
Twyla B. Sousa ◽  
...  
Keyword(s):  
Nuclear Organization ◽  
Serotonergic System ◽  
The Brain

scholarly journals Genetic approaches to the investigation of serotonergic neuron functions in animals

2019 ◽  
Vol 23 (4) ◽  
pp. 448-455
Author(s):  
U. S. Drozd ◽  
E. V. Shaburova ◽  
N. N. Dygalo
Keyword(s):  
Developmental Stages ◽  
Sensory Information ◽  
Serotonergic System ◽  
Serotonergic Neurons ◽  
Neurotransmitter Systems ◽  
New Therapeutic Approaches ◽  
Serotonin System ◽  
The Brain

The serotonergic system is one of the most important neurotransmitter systems that take part in the regulation of vital CNS functions. The understanding of its mechanisms will help scientists create new therapeutic approaches to the treatment of mental and neurodegenerative diseases and find out how this neurotransmitter system interacts with other parts of the brain and regulates their activity. Since the serotonergic system anatomy and functionality are heterogeneous and complex, the best tools for studying them are based on manipulation of individual types of neurons without affecting neurons of other neurotransmitter systems. The selective cell control is possible due to the genetic determinism of their functions. Proteins that determine the uniqueness of the cell type are expressed under the regulation of cell-specific promoters. By using promoters that are specific for genes of the serotonin system, one can control the expression of a gene of interest in serotonergic neurons. Here we review approaches based on such promoters. The genetic models to be discussed in the article have already shed the light on the role of the serotonergic system in modulating behavior and processing sensory information. In particular, genetic knockouts of serotonin genes sert, pet1, and tph2 promoted the determination of their contribution to the development and functioning of the brain. In addition, the review describes inducible models that allow gene expression to be controlled at various developmental stages. Finally, the application of these genetic approaches in optogenetics and chemogenetics provided a new resource for studying the functions, discharge activity, and signal transduction of serotonergic neurons. Nevertheless, the advantages and limitations of the discussed genetic approaches should be taken into consideration in the course of creating models of pathological conditions and developing pharmacological treatments for their correction.

scholarly journals Is the role of melatonin in induction of ovulation in the light-induced constant estrous anovulatory state mediated through the brain serotonergic system ?

1980 ◽  
Vol 20 (6) ◽  
pp. 1893-1898 ◽  
Author(s):  
Carmela F DE GAETANI ◽  
Rosanna POGGIOLI ◽  
Paola FERRARI ◽  
B. MESS ◽  
G. P. TRENTINI
Keyword(s):  
Serotonergic System ◽  
Induction Of Ovulation ◽  
The Brain
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