The role of PDLIM1, a PDZ‐LIM domain protein, at the ribbon synapses in the chicken retina

2020 ◽  
Vol 528 (11) ◽  
pp. 1820-1832 ◽  
Author(s):  
Hugo Ríos ◽  
Alejandra R. Paganelli ◽  
Nicolás S. Fosser
Keyword(s):  
Lim Domain ◽  
Ribbon Synapses ◽  
Lim Domain Protein ◽  
Domain Protein ◽  
Chicken Retina

scholarly journals ABSENCE OF FOUR-AND-A-HALF LIM DOMAIN PROTEIN 2 DECREASES ATHEROSCLEROSIS IN APOE-/- MICE: ROLE OF MONOCYTIC IMMUNE CELLS

2014 ◽  
Vol 30 (10) ◽  
pp. S320
Author(s):  
T. Ebrahimian ◽  
D. Simon ◽  
C.A. Lemarié ◽  
S. Simeone ◽  
M. Heidari ◽  
...  
Keyword(s):  
Immune Cells ◽  
Lim Domain ◽  
Lim Domain Protein ◽  
Domain Protein

scholarly journals The LIM-Only Protein FHL2 is involved in autophagy to regulate the development of skeletal muscle cell

2018 ◽  
Author(s):  
Zihao Liu ◽  
Shunshun Han ◽  
Yan Wang ◽  
Can Cui ◽  
Qing Zhu ◽  
...  
Keyword(s):  
Muscle Development ◽  
C2c12 Cells ◽  
Marker Genes ◽  
Lim Domain ◽  
Lim Domain Protein ◽  
Electron Microscopy Analysis ◽  
Microscopy Analysis ◽  
Mouse Cells ◽  
Domain Protein

AbstractFour and a half LIM domain protein 2 (FHL2) is a LIM domain protein expressed in muscle tissue whose deletion is causative of myopathies. Although FHL2 has a confirmed important role in muscle development, its autophagy-related function in muscle differentiation has not been fully determined. To explore the role of FHL2 in autophagy-related muscle regulation, FHL2-silenced and -overexpressing C2C12 mouse cells were examined. Immunofluorescence and co-immunoprecipitation assay findings showed that FHL2 silencing reduced LC3-Ⅱ protein expression and the amount of LC3 that co-immunoprecipitated with FHL2, indicating that FHL2 interacts with LC3-Ⅱ in the formation of autophagosomes. Moreover, the expression of muscle development marker genes such as MyoD1 and MyoG was lower in FHL2-silenced C2C12 cells but not in FHL2-overexpressing C2C12 cells. Electron microscopy analysis revealed large empty autophagosomes in FHL2-silenced myoblasts, while flow cytometry suggested that FHL2 silencing made cells more vulnerable to staurosporine-induced cell death. In conclusion, we propose that FHL2 interacts with LC3-Ⅱ in autophagosome formation to regulate the development of muscle cells.

Inhibition of Four- and-a-Half-Lim Domain Protein-2 Decreases Atherosclerosis in APOE -/- Mice Model: Role of Immune T-Cells

2013 ◽  
Vol 29 (10) ◽  
pp. S229-S230
Author(s):  
T. Ebrahimian ◽  
M. Heidari ◽  
C.A. Lemarie ◽  
S. Simeone ◽  
D. Simon ◽  
...  
Keyword(s):  
T Cells ◽  
Mice Model ◽  
Lim Domain ◽  
Lim Domain Protein ◽  
Domain Protein

Proteomic identification of the LIM domain protein FHL1 as the gene-product mutated in reducing body myopathy

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
J Schessl ◽  
Y Zou ◽  
MJ McGrath ◽  
BS Cowling ◽  
B Maiti ◽  
...  
Keyword(s):  
Gene Product ◽  
Lim Domain ◽  
Lim Domain Protein ◽  
Proteomic Identification ◽  
Domain Protein

scholarly journals Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity

Metabolism ◽  
2021 ◽  
pp. 154815
Author(s):  
Maria P. Clemente-Olivo ◽  
Jayron J. Habibe ◽  
Mariska Vos ◽  
Roelof Ottenhoff ◽  
Aldo Jongejan ◽  
...  
Keyword(s):  
Lim Domain ◽  
Human Obesity ◽  
Diet Induced Obesity ◽  
Lim Domain Protein ◽  
Domain Protein

scholarly journals The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tannaz Norizadeh Abbariki ◽  
Zita Gonda ◽  
Denise Kemler ◽  
Pavel Urbanek ◽  
Tabea Wagner ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cells ◽  
Muscle Regeneration ◽  
Myogenic Differentiation ◽  
Skeletal Muscle Regeneration ◽  
Temporal Control ◽  
Lim Domain ◽  
Lim Domain Protein ◽  
Domain Protein

AbstractThe process of myogenesis which operates during skeletal muscle regeneration involves the activation of muscle stem cells, the so-called satellite cells. These then give rise to proliferating progenitors, the myoblasts which subsequently exit the cell cycle and differentiate into committed precursors, the myocytes. Ultimately, the fusion of myocytes leads to myofiber formation. Here we reveal a role for the transcriptional co-regulator nTRIP6, the nuclear isoform of the LIM-domain protein TRIP6, in the temporal control of myogenesis. In an in vitro model of myogenesis, the expression of nTRIP6 is transiently up-regulated at the transition between proliferation and differentiation, whereas that of the cytosolic isoform TRIP6 is not altered. Selectively blocking nTRIP6 function results in accelerated early differentiation followed by deregulated late differentiation and fusion. Thus, the transient increase in nTRIP6 expression appears to prevent premature differentiation. Accordingly, knocking out the Trip6 gene in satellite cells leads to deregulated skeletal muscle regeneration dynamics in the mouse. Thus, dynamic changes in nTRIP6 expression contributes to the temporal control of myogenesis.

Chromosomal mapping, tissue distribution and cDNA sequence of Four-and-a-half LIM domain protein 1 (FHL1)

Gene ◽  
1998 ◽  
Vol 216 (1) ◽  
pp. 163-170 ◽  
Author(s):  
Simon Ming Yuen Lee ◽  
Stephen Kwok Wing Tsui ◽  
Kwok Keung Chan ◽  
Merce Garcia-Barcelo ◽  
Mary Miu Yee Waye ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Cdna Sequence ◽  
Chromosomal Mapping ◽  
Lim Domain ◽  
Lim Domain Protein ◽  
Domain Protein
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