scholarly journals Sonic hedgehog expression in zebrafish forebrain identifies the teleostean pallidal signaling center and shows preglomerular complex and posterior tubercular dopamine cells to arise from shh cells

2020 ◽  
Vol 528 (8) ◽  
pp. 1321-1348 ◽  
Author(s):  
Mario F. Wullimann ◽  
Kosisochukwu E. Umeasalugo
Keyword(s):  
Sonic Hedgehog ◽  
Signaling Center

scholarly journals FGFs are orchestra conductors of Shh-dependent oligodendroglial fate specification in the ventral spinal cord

2017 ◽  
Author(s):  
Marie-Amélie Farreny ◽  
Eric Agius ◽  
Sophie Bel-Vialar ◽  
Nathalie Escalas ◽  
Nagham Khouri-Farah ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Progenitor Cells ◽  
Sonic Hedgehog ◽  
Fgf Signaling ◽  
Oligodendrocyte Precursor Cell ◽  
Signaling Center ◽  
Oligodendrocyte Precursor ◽  
Prevailing View ◽  
Ventral Spinal Cord

AbstractMost oligodendrocytes of the spinal cord originate from ventral progenitor cells of the pMN domain, characterized by expression of the transcription factor Olig2. A minority of oligodendrocytes is also recognized to emerge from dorsal progenitors during fetal development. The prevailing view is that generation of ventral oligodendrocytes depends on Sonic hedgehog (Shh) while dorsal oligodendrocytes develop under the influence of Fibroblast Growth Factors (FGFs). Using the well-established model of the chicken embryo, we evidence that ventral spinal progenitor cells activate FGF signaling at the onset of oligodendrocyte precursor cell (OPC) generation, as do they dorsal counterpart. Inhibition of FGF receptors at that time appears sufficient to prevent generation of ventral OPCs, highlighting that, in addition to Shh, FGF signaling is required also for generation of ventral OPCs. We further reveal an unsuspected interplay between Shh and FGF signaling by showing that FGFs serve dual essential functions in ventral OPC specification. FGFs are responsible for timely induction of a secondary Shh signaling center, the lateral floor plate, a crucial step to create the burst of Shh required for OPC specification. At the same time, FGFs prevent down-regulation of Olig2 in pMN progenitor cells as these cells receive higher threshold of the Shh signal. Finally, we bring arguments favoring a key role of newly differentiated neurons acting as providers of the FGF signal required to trigger OPC generation in the ventral spinal cord.

672: Regulation of Cavernous Nerve Injury-Induced Apoptosis by Sonic Hedgehog

2007 ◽  
Vol 177 (4S) ◽  
pp. 225-225
Author(s):  
Carol A. Podlasek ◽  
Yi Tang ◽  
Cynthia L. Meraz ◽  
Kevin E. McKenna ◽  
Kevin T. McVary
Keyword(s):  
Nerve Injury ◽  
Sonic Hedgehog ◽  
Cavernous Nerve ◽  
Induced Apoptosis ◽  
Cavernous Nerve Injury

Crosstalk between Sonic hedgehog and CRH pathways leading to a synergic effect on ACTH secretion

2004 ◽  
Vol 112 (S 1) ◽  
Author(s):  
G Vila ◽  
M Theodoropoulou ◽  
M Papazoglou ◽  
J Stalla ◽  
U Renner ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Synergic Effect ◽  
Acth Secretion
Sign in / Sign up

Export Citation Format

Share Document