Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair

2019 ◽  
Author(s):  
Sepand Rastegar ◽  
Avinash Parimisetty ◽  
Nora Cassam Sulliman ◽  
Sai Sandhya Narra ◽  
Sabrina Weber ◽  
...  
Keyword(s):  
Adult Zebrafish ◽  
Adiponectin Receptors ◽  
Brain Repair ◽  
The Brain

scholarly journals Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals After Injury

2020 ◽  
Author(s):  
Batoul Ghaddar ◽  
Luisa Lübke ◽  
David COURET ◽  
Sepand Rastegar ◽  
Nicolas Diotel
Keyword(s):  
Stem Cells ◽  
Adult Neurogenesis ◽  
Brain Plasticity ◽  
Adult Zebrafish ◽  
Cellular Mechanisms ◽  
Regenerative Capacity ◽  
Brain Repair ◽  
Cellular Events ◽  
Similarities And Differences ◽  
The Brain

Adult neurogenesis is an evolutionary conserved process occurring in all vertebrates. However, striking differences are observed between the taxa, considering the number of neurogenic niches, the neural stem cell (NSC) identity and brain plasticity under constitutive and injury-induced conditions. Zebrafish has become a popular model for the investigation of the molecular and cellular mechanisms involved in adult neurogenesis. Compared to mammals, the adult zebrafish displays a high number of neurogenic niches distributed throughout the brain. Furthermore, it exhibits a strong regenerative capacity without scar formation or any obvious disabilities. In this review, we will first discuss the similarities and differences regarding (i) the distribution of neurogenic niches in the brain of adult zebrafish and mammals (mainly mouse) and (ii) the nature of the neural stem cells within the main telencephalic niches. In the second part, we will describe the cascade of cellular events occurring after telencephalic injury in zebrafish and mouse. Our study clearly shows that most early events happening right after the brain injury are shared between zebrafish and mouse including cell death, microglia and oligodendrocyte recruitment, as well as injury-induced neurogenesis. In mammals one of the consequences following an injury is the formation of a glial scar that is persistent. This is not the case in zebrafish, which may be one of the main reasons that zebrafish display a higher regenerative capacity.

scholarly journals Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 391
Author(s):  
Batoul Ghaddar ◽  
Luisa Lübke ◽  
David Couret ◽  
Sepand Rastegar ◽  
Nicolas Diotel
Keyword(s):  
Stem Cells ◽  
Adult Neurogenesis ◽  
Brain Plasticity ◽  
Adult Zebrafish ◽  
Cellular Mechanisms ◽  
Regenerative Capacity ◽  
Brain Repair ◽  
Cellular Events ◽  
Similarities And Differences ◽  
The Brain

Adult neurogenesis is an evolutionary conserved process occurring in all vertebrates. However, striking differences are observed between the taxa, considering the number of neurogenic niches, the neural stem cell (NSC) identity, and brain plasticity under constitutive and injury-induced conditions. Zebrafish has become a popular model for the investigation of the molecular and cellular mechanisms involved in adult neurogenesis. Compared to mammals, the adult zebrafish displays a high number of neurogenic niches distributed throughout the brain. Furthermore, it exhibits a strong regenerative capacity without scar formation or any obvious disabilities. In this review, we will first discuss the similarities and differences regarding (i) the distribution of neurogenic niches in the brain of adult zebrafish and mammals (mainly mouse) and (ii) the nature of the neural stem cells within the main telencephalic niches. In the second part, we will describe the cascade of cellular events occurring after telencephalic injury in zebrafish and mouse. Our study clearly shows that most early events happening right after the brain injury are shared between zebrafish and mouse including cell death, microglia, and oligodendrocyte recruitment, as well as injury-induced neurogenesis. In mammals, one of the consequences following an injury is the formation of a glial scar that is persistent. This is not the case in zebrafish, which may be one of the main reasons that zebrafish display a higher regenerative capacity.

Exposure to aluminium causes behavioural alterations and oxidative stress in the brain of adult zebrafish

2021 ◽  
Vol 85 ◽  
pp. 103636
Author(s):  
Teresa Capriello ◽  
Luis M. Félix ◽  
Sandra M. Monteiro ◽  
Dércia Santos ◽  
Rita Cofone ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Zebrafish ◽  
The Brain ◽  
And Oxidative Stress

Effects of chronic exposure to bisphenol-S on social behaviors in adult zebrafish: Disruption of the neuropeptide signaling pathways in the brain

2020 ◽  
Vol 262 ◽  
pp. 113992 ◽  
Author(s):  
Arash Salahinejad ◽  
Mohammad Naderi ◽  
Anoosha Attaran ◽  
Denis Meuthen ◽  
Som Niyogi ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Chronic Exposure ◽  
Social Behaviors ◽  
Adult Zebrafish ◽  
Bisphenol S ◽  
The Brain

scholarly journals Electrophysiological Recording in the Brain of Intact Adult Zebrafish

10.3791/51065 ◽  
2013 ◽  
Author(s):  
Lindsey Johnston ◽  
Rebecca E. Ball ◽  
Seth Acuff ◽  
John Gaudet ◽  
Andrew Sornborger ◽  
...  
Keyword(s):  
Electrophysiological Recording ◽  
Adult Zebrafish ◽  
The Brain

scholarly journals Behavioral Impairments and Oxidative Stress in the Brain, Muscle, and Gill Caused by Chronic Exposure of C70 Nanoparticles on Adult Zebrafish

2019 ◽  
Vol 20 (22) ◽  
pp. 5795 ◽  
Author(s):  
Sreeja Sarasamma ◽  
Gilbert Audira ◽  
Prabu Samikannu ◽  
Stevhen Juniardi ◽  
Petrus Siregar ◽  
...  
Keyword(s):  
High Dose ◽  
Adult Zebrafish ◽  
Activity Impairment ◽  
Skin Cells ◽  
Biochemical Assays ◽  
Muscle Tissues ◽  
Behavioral Impairments ◽  
Α Level ◽  
The Brain ◽  
Brain Tissues

There is an imperative need to develop efficient whole-animal-based testing assays to determine the potential toxicity of engineered nanomaterials. While previous studies have demonstrated toxicity in lung and skin cells after C70 nanoparticles (NPs) exposure, the potential detrimental role of C70 NPs in neurobehavior is largely unaddressed. Here, we evaluated the chronic effects of C70 NPs exposure on behavior and alterations in biochemical responses in adult zebrafish. Two different exposure doses were used for this experiment: low dose (0.5 ppm) and high dose (1.5 ppm). Behavioral tests were performed after two weeks of exposure of C70 NPs. We found decreased locomotion, exploration, mirror biting, social interaction, and shoaling activities, as well as anxiety elevation and circadian rhythm locomotor activity impairment after ~2 weeks in the C70 NP-exposed fish. The results of biochemical assays reveal that following exposure of zebrafish to 1.5 ppm of C70 NPs, the activity of superoxide dismutase (SOD) in the brain and muscle tissues increased significantly. In addition, the concentration of reactive oxygen species (ROS) also increased from 2.95 ± 0.12 U/ug to 8.46 ± 0.25 U/ug and from 0.90 ± 0.03 U/ug to 3.53 ± 0.64 U/ug in the muscle and brain tissues, respectively. Furthermore, an increased level of cortisol was also observed in muscle and brain tissues, ranging from 17.95 ± 0.90 pg/ug to 23.95 ± 0.66 pg/ug and from 3.47 ± 0.13 pg/ug to 4.91 ± 0.51 pg/ug, respectively. Increment of Hif1-α level was also observed in both tissues. The elevation was ranging from 11.65 ± 0.54 pg/ug to 18.45 ± 1.00 pg/ug in the muscle tissue and from 4.26 ± 0.11 pg/ug to 6.86 ± 0.37 pg/ug in the brain tissue. Moreover, the content of DNA damage and inflammatory markers such as ssDNA, TNF-α, and IL-1β were also increased substantially in the brain tissues. Significant changes in several biomarker levels, including catalase and malondialdehyde (MDA), were also observed in the gill tissues. Finally, we used a neurophenomic approach with a particular focus on environmental influences, which can also be easily adapted for other aquatic fish species, to assess the toxicity of metal and carbon-based nanoparticles. In summary, this is the first study to illustrate the adult zebrafish toxicity and the alterations in several neurobehavior parameters after zebrafish exposure to environmentally relevant amounts of C70 NPs.

scholarly journals Modulation of the chelatable Zn pool in the brain by diethyldithiocarbamate is associated with behavioral impairment in adult zebrafish

2015 ◽  
Vol 4 (2) ◽  
pp. 317-325 ◽  
Author(s):  
Marcos M. Braga ◽  
Emerson S. Silva ◽  
Eduardo P. Rico ◽  
Leticia F. Pettenuzzo ◽  
Diogo L. Oliveira ◽  
...  
Keyword(s):  
Adult Zebrafish ◽  
Behavioral Impairment ◽  
The Brain

DEDTC leads to a buildup of DEDTC in the brain with consequent chelation of reactive Zn and behavioral impairment of zebrafish.

bdnf and ntrk2b Gene Expression Profile in the Brain of Adult Zebrafish after Induced Seizure (PD3.001)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. PD3.001-PD3.001 ◽  
Author(s):  
F. C. Reis-Pinto ◽  
P. Barbalho ◽  
R. Mangolin ◽  
C. Maurer-Morelli
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Adult Zebrafish ◽  
The Brain
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