Neural stem/progenitor cells are activated during tail regeneration in the leopard gecko (Eublepharis macularius)

2017 ◽  
Vol 526 (2) ◽  
pp. 285-309 ◽  
Author(s):  
E.A.B. Gilbert ◽  
M.K. Vickaryous
Keyword(s):  
Progenitor Cells ◽  
Tail Regeneration ◽  
Eublepharis Macularius ◽  
Leopard Gecko ◽  
Neural Stem Progenitor Cells

scholarly journals Cutaneous tactile sensitivity before and after tail loss and regeneration in the leopard gecko (Eublepharis macularius)

2021 ◽  
pp. jeb.234054
Author(s):  
Stefanie S. Bradley ◽  
Erika Howe ◽  
Leah R. Bent ◽  
Matthew K. Vickaryous
Keyword(s):  
Sudden Change ◽  
The Body ◽  
Tactile Sensitivity ◽  
Predator Detection ◽  
Natural Form ◽  
Tail Regeneration ◽  
Tail Loss ◽  
Eublepharis Macularius ◽  
Tail Autotomy ◽  
Leopard Gecko

Amongst tetrapods, mechanoreceptors on the feet establish a sense of body placement and help to facilitate posture and biomechanics. Mechanoreceptors are necessary for stabilizing the body while navigating through changing terrains or responding to a sudden change in body mass and orientation. Lizards such as the leopard gecko (Eublepharis macularius) employ autotomy – a voluntary detachment of a portion of the tail, to escape predation. Tail autotomy represents a natural form of significant (and localized) mass loss. Semmes-Weinstein monofilaments were used to investigate the effect of tail autotomy (and subsequent tail regeneration) on tactile sensitivity of each appendage of the leopard gecko. Prior to autotomy, we identified site-specific differences in tactile sensitivity across the ventral surfaces of the hindlimbs, forelimbs, and tail. Repeated monofilament testing of both control (tail-intact) and tail loss geckos had a significant sensitization effect (i.e., decrease in tactile threshold, maintained over time) in all regions of interest except the palmar surfaces of the forelimbs in post-autotomy geckos, compared to baseline testing. Although the regenerated tail is not an exact replica of the original, tactile sensitivity is shown to be effectively restored at this site. Re-establishment of tactile sensitivity on the ventral surface of the regenerate tail points towards a (continued) role in predator detection.

scholarly journals Characterization of TGFβ signaling during tail regeneration in the leopard Gecko (Eublepharis macularius)

2013 ◽  
Vol 242 (7) ◽  
pp. 886-896 ◽  
Author(s):  
Richard W.D. Gilbert ◽  
Matthew K. Vickaryous ◽  
Alicia M. Viloria-Petit
Keyword(s):  
Tgfβ Signaling ◽  
Tail Regeneration ◽  
Eublepharis Macularius ◽  
Leopard Gecko

scholarly journals Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. VOLUME 283 (2008) PAGES 27644-27652

2009 ◽  
Vol 284 (13) ◽  
pp. 8995
Author(s):  
Xuekun Li ◽  
Basam Z. Barkho ◽  
Jinfeng Bao ◽  
Yuping Luo ◽  
Richard D. Smrt ◽  
...  
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Epigenetic Regulation ◽  
Neural Stem Progenitor Cells ◽  
Cell Mitogen
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