Anterior and posterior parts of the rat ventral tegmental area and the rostromedial tegmental nucleus receive topographically distinct afferents from the lateral habenular complex

2017 ◽  
Vol 525 (10) ◽  
pp. 2310-2327 ◽  
Author(s):  
Anja Petzel ◽  
René Bernard ◽  
Wolfram C. Poller ◽  
Rüdiger W. Veh
Keyword(s):  
Ventral Tegmental Area ◽  
Tegmental Nucleus ◽  
Rostromedial Tegmental Nucleus ◽  
Ventral Tegmental

scholarly journals Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat

2015 ◽  
Vol 523 (16) ◽  
pp. 2426-2456 ◽  
Author(s):  
Leora Yetnikoff ◽  
Anita Y. Cheng ◽  
Heather N. Lavezzi ◽  
Kenneth P. Parsley ◽  
Daniel S. Zahm
Keyword(s):  
Ventral Tegmental Area ◽  
Lateral Habenula ◽  
Tegmental Nucleus ◽  
Rostromedial Tegmental Nucleus ◽  
Ventral Tegmental

Cholinergic control of morphine-induced locomotion in rostromedial tegmental nucleus versus ventral tegmental area sites

2013 ◽  
Vol 38 (5) ◽  
pp. 2774-2785 ◽  
Author(s):  
David I. Wasserman ◽  
Haoran G. Wang ◽  
Asim J. Rashid ◽  
Sheena A. Josselyn ◽  
John S. Yeomans
Keyword(s):  
Ventral Tegmental Area ◽  
Tegmental Nucleus ◽  
Rostromedial Tegmental Nucleus ◽  
Ventral Tegmental

scholarly journals Functional evidence for a direct excitatory projection from the lateral habenula to the ventral tegmental area in the rat

2016 ◽  
Vol 116 (3) ◽  
pp. 1161-1174 ◽  
Author(s):  
P. Leon Brown ◽  
Paul D. Shepard
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Lateral Habenula ◽  
Aversive Stimuli ◽  
Rat Pups ◽  
Tegmental Nucleus ◽  
Fasciculus Retroflexus ◽  
Ventral Tegmental ◽  
Midbrain Dopamine ◽  
Midbrain Dopamine Neurons

The lateral habenula, a phylogenetically conserved epithalamic structure, is activated by aversive stimuli and reward omission. Excitatory efferents from the lateral habenula predominately inhibit midbrain dopamine neuronal firing through a disynaptic, feedforward inhibitory mechanism involving the rostromedial tegmental nucleus. However, the lateral habenula also directly targets dopamine neurons within the ventral tegmental area, suggesting that opposing actions may result from increased lateral habenula activity. In the present study, we tested the effect of habenular efferent stimulation on dopamine and nondopamine neurons in the ventral tegmental area of Sprague-Dawley rats using a parasagittal brain slice preparation. Single pulse stimulation of the fasciculus retroflexus excited 48% of dopamine neurons and 51% of nondopamine neurons in the ventral tegmental area of rat pups. These proportions were not altered by excision of the rostromedial tegmental nucleus and were evident in both cortical- and striatal-projecting dopamine neurons. Glutamate receptor antagonists blocked this excitation, and fasciculus retroflexus stimulation elicited evoked excitatory postsynaptic potentials with a nearly constant onset latency, indicative of a monosynaptic, glutamatergic connection. Comparison of responses in rat pups and young adults showed no significant difference in the proportion of neurons excited by fasciculus retroflexus stimulation. Our data indicate that the well-known, indirect inhibitory effect of lateral habenula activation on midbrain dopamine neurons is complemented by a significant, direct excitatory effect. This pathway may contribute to the role of midbrain dopamine neurons in processing aversive stimuli and salience.

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