Expression of transcription factors divides retinal ganglion cells into distinct classes

2017 ◽  
Vol 527 (1) ◽  
pp. 225-235 ◽  
Author(s):  
Neal T. Sweeney ◽  
Kiely N. James ◽  
Andreea Nistorica ◽  
Ryan M. Lorig-Roach ◽  
David A. Feldheim
Keyword(s):  
Transcription Factors ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

Co-expression of heat shock transcription factors 1 and 2 in rat retinal ganglion cells

2006 ◽  
Vol 405 (3) ◽  
pp. 191-195 ◽  
Author(s):  
Jacky M.K. Kwong ◽  
Maziar Lalezary ◽  
Jessica K. Nguyen ◽  
Christine Yang ◽  
Anuj Khattar ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Heat Shock ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Heat Shock Transcription Factors

Reprogramming to help the old see like the young

2020 ◽  
Vol 12 (574) ◽  
pp. eabf7738
Author(s):  
Carlos A. Aguilar
Keyword(s):  
Transcription Factors ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Aged Mouse ◽  
Retinal Ganglion ◽  
Functional Characteristics ◽  
Factors Associated

Transcription factors associated with pluripotency restore molecular and functional characteristics resembling youth in aged mouse retinal ganglion cells.

scholarly journals Whole Number, Distribution and Co-Expression of Brn3 Transcription Factors in Retinal Ganglion Cells of Adult Albino and Pigmented Rats

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49830 ◽  
Author(s):  
Francisco M. Nadal-Nicolás ◽  
Manuel Jiménez-López ◽  
Manuel Salinas-Navarro ◽  
Paloma Sobrado-Calvo ◽  
Juan J. Alburquerque-Béjar ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Number Distribution ◽  
Whole Number

scholarly journals Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Fuguo Wu ◽  
Jonathan E. Bard ◽  
Julien Kann ◽  
Donald Yergeau ◽  
Darshan Sapkota ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Transitional Cell ◽  
Retinal Ganglion ◽  
Rna Seq ◽  
Wild Type ◽  
Transitional State ◽  
Retinal Progenitor ◽  
Lineage Specific Genes

AbstractAtoh7 has been believed to be essential for establishing the retinal ganglion cell (RGC) lineage, and Pou4f2 and Isl1 are known to regulate RGC specification and differentiation. Here we report our further study of the roles of these transcription factors. Using bulk RNA-seq, we identify genes regulated by the three transcription factors, which expand our understanding of the scope of downstream events. Using scRNA-seq on wild-type and mutant retinal cells, we reveal a transitional cell state of retinal progenitor cells (RPCs) co-marked by Atoh7 and other genes for different lineages and shared by all early retinal lineages. We further discover the unexpected emergence of the RGC lineage in the absence of Atoh7. We conclude that competence of RPCs for different retinal fates is defined by lineage-specific genes co-expressed in the transitional state and that Atoh7 defines the RGC competence and collaborates with other factors to shepherd transitional RPCs to the RGC lineage.

scholarly journals Transcription Factors SOX4 and SOX11 Function Redundantly to Regulate the Development of Mouse Retinal Ganglion Cells

2013 ◽  
Vol 288 (25) ◽  
pp. 18429-18438 ◽  
Author(s):  
Ying Jiang ◽  
Qian Ding ◽  
Xiaoling Xie ◽  
Richard T. Libby ◽  
Veronique Lefebvre ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

scholarly journals Distinct Roles of Transcription Factors Brn3a and Brn3b in Controlling the Development, Morphology, and Function of Retinal Ganglion Cells

Neuron ◽  
2009 ◽  
Vol 61 (6) ◽  
pp. 852-864 ◽  
Author(s):  
Tudor C. Badea ◽  
Hugh Cahill ◽  
Jen Ecker ◽  
Samer Hattar ◽  
Jeremy Nathans
Keyword(s):  
Transcription Factors ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
And Function
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