Mid-life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ-associated pathology and positively influences synaptic and cognitive health in healthy ageing

2017 ◽  
Vol 525 (8) ◽  
pp. 1797-1810 ◽  
Author(s):  
Kimberley E. Stuart ◽  
Anna E. King ◽  
Carmen M. Fernandez-Martos ◽  
Justin Dittmann ◽  
Mathew J. Summers ◽  
...  
Keyword(s):  
Mouse Model ◽  
Environmental Enrichment ◽  
Healthy Ageing ◽  
Synaptic Density ◽  
Cognitive Health

scholarly journals Environmental enrichment improves metabolic and behavioral health in the BTBR mouse model of autism

2020 ◽  
Vol 111 ◽  
pp. 104476 ◽  
Author(s):  
Nicholas J. Queen ◽  
Amber A. Boardman ◽  
Ripal S. Patel ◽  
Jason J. Siu ◽  
Xiaokui Mo ◽  
...  
Keyword(s):  
Mouse Model ◽  
Behavioral Health ◽  
Environmental Enrichment ◽  
Btbr Mouse

Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment

2006 ◽  
Vol 23 (7) ◽  
pp. 1829-1838 ◽  
Author(s):  
Stanley E. Lazic ◽  
Helen E. Grote ◽  
Colin Blakemore ◽  
Anthony J. Hannan ◽  
Anton van Dellen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Transgenic Mouse ◽  
Environmental Enrichment ◽  
Transgenic Mouse Model

scholarly journals Moderate Environmental Enrichment Mitigates Tauopathy in a Neurofibrillary Tangle Mouse Model

2011 ◽  
Vol 70 (7) ◽  
pp. 610-621 ◽  
Author(s):  
Inbal Lahiani-Cohen ◽  
Athanasios Lourbopoulos ◽  
Ester Haber ◽  
Lea Rozenstein-Tsalkovich ◽  
Oded Abramsky ◽  
...  
Keyword(s):  
Mouse Model ◽  
Environmental Enrichment ◽  
Neurofibrillary Tangle

scholarly journals Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome

eNeuro ◽  
2016 ◽  
Vol 3 (5) ◽  
pp. ENEURO.0103-16.2016 ◽  
Author(s):  
Silvina Catuara-Solarz ◽  
Jose Espinosa-Carrasco ◽  
Ionas Erb ◽  
Klaus Langohr ◽  
Juan Ramon Gonzalez ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Environmental Enrichment ◽  
Combined Treatment ◽  
Learning Deficits ◽  
Hippocampal Alterations

scholarly journals Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model

2020 ◽  
Vol 21 (3) ◽  
pp. 843
Author(s):  
Lisa S. Robison ◽  
Nikita Francis ◽  
Dominique L. Popescu ◽  
Maria E. Anderson ◽  
Joshua Hatfield ◽  
...  
Keyword(s):  
Physical Activity ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Cerebral Amyloid Angiopathy ◽  
Environmental Enrichment ◽  
Transgenic Mouse Model ◽  
Cognitive Stimulation ◽  
Cognitive Behavioral ◽  
Amyloid Angiopathy ◽  
Cerebral Amyloid

Cerebral amyloid angiopathy (CAA) is the deposition of amyloid protein in the cerebral vasculature, a common feature in both aging and Alzheimer’s disease (AD). However, the effects of environmental factors, particularly cognitive stimulation, social stimulation, and physical activity, on CAA pathology are poorly understood. These factors, delivered in the form of the environmental enrichment (EE) paradigm in rodents, have been shown to have beneficial effects on the brain and behavior in healthy aging and AD models. However, the relative importance of these subcomponents on CAA pathology has not been investigated. Therefore, we assessed the effects of EE, social enrichment (SOC), and cognitive enrichment (COG) compared to a control group that was single housed without enrichment (SIN) from 4 to 8 months of age in wild-type mice (WT) and Tg-SwDI mice, a transgenic mouse model of CAA that exhibits cognitive/behavioral deficits. The results show that individual facets of enrichment can affect an animal model of CAA, though the SOC and combined EE conditions are generally the most effective at producing physiological, cognitive/behavioral, and neuropathological changes, adding to a growing literature supporting the benefits of lifestyle interventions.

scholarly journals Specific profile of ultrasonic communication in a mouse model of neurodevelopmental disorders

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Marika Premoli ◽  
Sara Anna Bonini ◽  
Andrea Mastinu ◽  
Giuseppina Maccarinelli ◽  
Francesca Aria ◽  
...  
Keyword(s):  
Mouse Model ◽  
Social Communication ◽  
Neurodevelopmental Disorders ◽  
Environmental Enrichment ◽  
Maternal Separation ◽  
Wild Type ◽  
Social Investigation ◽  
Behavioural Phenotyping ◽  
Ultrasonic Communication ◽  
Specific Profile

Abstract Mice emit ultrasonic vocalizations (USVs) in different social conditions: pups maternal separation, juveniles play, adults mating and social investigation. The USVs measurement has become an important instrument for behavioural phenotyping in neurodevelopmental disorders (NDDs). Recently, we have demonstrated that the deletion of the NFκB1 gene, which encodes the p50 NF-κB subunit, causes NDDs phenotype in mice. In this study, we investigated the ultrasonic communication and the effects of an early social enrichment in mice lacking the NF-κB p50 subunit (p50 KO). In particular, USVs of wild-type (WT), p50 KO and KO exposed to early social enrichment (KO enriched) were recorded using an ultrasound sensitive microphone and analysed by Avisoft software. USVs analysis showed that p50 KO pups emit more and longer vocalizations compared to WT pups. On the contrary, in adulthood, p50 KO mice emit less USVs than WT mice. We also found significant qualitative differences in p50 KO mice USVs compared to WT mice; the changes specifically involved two USVs categories. Early social enrichment had no effect on USVs number, duration and type in p50 KO mice. Together, these data revealed social communication alterations in a mouse model of NDDs; these deficits were not recovered by early social enrichment, strengthening the fact that genetic background prevails on environmental enrichment.

Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis

2008 ◽  
Vol 28 (4) ◽  
pp. 717-723 ◽  
Author(s):  
Nathan C. Stam ◽  
Jess Nithianantharajah ◽  
Monique L. Howard ◽  
Julie D. Atkin ◽  
Surindar S. Cheema ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Environmental Enrichment ◽  
Transgenic Mouse Model ◽  
Behavioural Effects ◽  
Lateral Sclerosis
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