Matrix metalloproteinases as promising regulators of axonal regrowth in the injured adult zebrafish retinotectal system

2015 ◽  
Vol 524 (7) ◽  
pp. 1472-1493 ◽  
Author(s):  
Kim Lemmens ◽  
Ilse Bollaerts ◽  
Stitipragyan Bhumika ◽  
Lies de Groef ◽  
Jessie Van Houcke ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Adult Zebrafish ◽  
Axonal Regrowth ◽  
Retinotectal System

Axonal regrowth after spinal cord transection in adult zebrafish

1997 ◽  
Vol 377 (4) ◽  
pp. 577-595 ◽  
Author(s):  
Thomas Becker ◽  
Mario F. Wullimann ◽  
Catherina G. Becker ◽  
Robert R. Bernhardt ◽  
Melitta Schachner
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Transection ◽  
Adult Zebrafish ◽  
Axonal Regrowth

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

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