scholarly journals Individual differences in cortical connections of somatosensory cortex are associated with parental rearing style in prairie voles (Microtus ochrogaster)

2015 ◽  
Vol 524 (3) ◽  
pp. 564-577 ◽  
Author(s):  
Adele M.H. Seelke ◽  
Allison M. Perkeybile ◽  
Rebecca Grunewald ◽  
Karen L. Bales ◽  
Leah A. Krubitzer
Keyword(s):  
Individual Differences ◽  
Somatosensory Cortex ◽  
Microtus Ochrogaster ◽  
Prairie Voles ◽  
Cortical Connections ◽  
Parental Rearing

scholarly journals Early-life sleep disruption increases parvalbumin in primary somatosensory cortex and impairs social bonding in prairie voles

2019 ◽  
Vol 5 (1) ◽  
pp. eaav5188 ◽  
Author(s):  
Carolyn E. Jones ◽  
Ryan A. Opel ◽  
Mara E. Kaiser ◽  
Alex Q. Chau ◽  
Jazmine R. Quintana ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Rem Sleep ◽  
Early Life ◽  
Neural Circuits ◽  
Microtus Ochrogaster ◽  
Primary Somatosensory Cortex ◽  
Sleep Disruption ◽  
Prairie Voles ◽  
Pair Bonds ◽  
Object Preference

Across mammals, juveniles sleep more than adults, with rapid eye movement (REM) sleep at a lifetime maximum early in life. One function of REM sleep may be to facilitate brain development of complex behaviors. Here, we applied 1 week of early-life sleep disruption (ELSD) in prairie voles (Microtus ochrogaster), a highly social rodent species that forms lifelong pair bonds. Electroencephalographic recordings from juvenile voles during ELSD revealed decreased REM sleep and reduced γ power compared to baseline. ELSD impaired pair bond formation and altered object preference in adulthood. Furthermore, ELSD increased GABAergic parvalbumin immunoreactivity in the primary somatosensory cortex in adulthood, a brain region relevant to both affected behaviors. We propose that, early in life, sleep is crucial for tuning inhibitory neural circuits and the development of species-typical affiliative social behavior.

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