scholarly journals A second corticotropin-releasing hormone gene (CRH2) is conserved across vertebrate classes and expressed in the hindbrain of a basal Neopterygian fish, the spotted gar (Lepisosteus oculatus)

2015 ◽  
Vol 523 (7) ◽  
pp. 1125-1143 ◽  
Author(s):  
Brian P. Grone ◽  
Karen P. Maruska
Keyword(s):  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Spotted Gar ◽  
Lepisosteus Oculatus

scholarly journals Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages

2016 ◽  
Vol 57 (1) ◽  
pp. 73-86 ◽  
Author(s):  
João C R Cardoso ◽  
Christina A Bergqvist ◽  
Rute C Félix ◽  
Dan Larhammar
Keyword(s):  
Teleost Fish ◽  
Gene Families ◽  
Corticotropin Releasing Hormone ◽  
Neighboring Gene ◽  
Receptor System ◽  
Releasing Hormone ◽  
Spotted Gar ◽  
Genome Doubling ◽  
Peptide Family ◽  
Lepisosteus Oculatus

The evolution of the peptide family consisting of corticotropin-releasing hormone (CRH) and the three urocortins (UCN1-3) has been puzzling due to uneven evolutionary rates. Distinct gene duplication scenarios have been proposed in relation to the two basal rounds of vertebrate genome doubling (2R) and the teleost fish-specific genome doubling (3R). By analyses of sequences and chromosomal regions, including many neighboring gene families, we show here that the vertebrate progenitor had two peptide genes that served as the founders of separate subfamilies. Then, 2R resulted in a total of five members: one subfamily consists of CRH1, CRH2, and UCN1. The other subfamily contains UCN2 and UCN3. All five peptide genes are present in the slowly evolving genomes of the coelacanth Latimeria chalumnae (a lobe-finned fish), the spotted gar Lepisosteus oculatus (a basal ray-finned fish), and the elephant shark Callorhinchus milii (a cartilaginous fish). The CRH2 gene has been lost independently in placental mammals and in teleost fish, but is present in birds (except chicken), anole lizard, and the nonplacental mammals platypus and opossum. Teleost 3R resulted in an additional surviving duplicate only for crh1 in some teleosts including zebrafish (crh1a and crh1b). We have previously reported that the two vertebrate CRH/UCN receptors arose in 2R and that CRHR1 was duplicated in 3R. Thus, we can now conclude that this peptide–receptor system was quite complex in the ancestor of the jawed vertebrates with five CRH/UCN peptides and two receptors, and that crh and crhr1 were duplicated in the teleost fish tetraploidization.

Corticotropin releasing hormone (CRH) is a proinflammatory peptide in mouse ileum

2001 ◽  
Vol 120 (5) ◽  
pp. A38-A39
Author(s):  
M WLK ◽  
C WANG ◽  
M VENICHAKI ◽  
S KUHNTMOORE ◽  
D ZHAO ◽  
...  
Keyword(s):  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Mouse Ileum

Dissecting the role of Corticotropin-releasing hormone receptor type 1 in Alzheimer's Disease

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
K Lerche ◽  
M Willem ◽  
K Kleinknecht ◽  
C Romberg ◽  
U Konietzko ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hormone Receptor ◽  
Receptor Type ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Testosterone modulates the corticotropin releasing hormone-induced pro-oxidant activity in macroendothelial cells

2020 ◽  
Author(s):  
Maria Filiponi ◽  
Sophia Gougoura ◽  
Christina Befani ◽  
Alexandra Bargiota ◽  
Panagiotis Liakos ◽  
...  
Keyword(s):  
Corticotropin Releasing Hormone ◽  
Releasing Hormone
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