scholarly journals Neurochemical characterization of extrinsic nerves in myenteric ganglia of the guinea pig distal colon

2014 ◽  
Vol 523 (5) ◽  
pp. 742-756 ◽  
Author(s):  
Bao Nan Chen ◽  
Dale F. Sharrad ◽  
Timothy J. Hibberd ◽  
Vladimir P. Zagorodnyuk ◽  
Marcello Costa ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Distal Colon ◽  
Myenteric Ganglia ◽  
Extrinsic Nerves

Synaptic behavior of myenteric neurons in guinea pig distal colon

1988 ◽  
Vol 255 (2) ◽  
pp. G184-G190 ◽  
Author(s):  
P. R. Wade ◽  
J. D. Wood
Keyword(s):  
Guinea Pig ◽  
Input Resistance ◽  
Distal Colon ◽  
Bathing Medium ◽  
Myenteric Neurons ◽  
Fiber Tracts ◽  
Slow Rise ◽  
Domain 3 ◽  
Myenteric Ganglia

Intracellular recording methods were used in vitro to analyze the synaptic behavior of neurons in myenteric ganglia of guinea pig distal colon. Fast excitatory postsynaptic potentials (EPSPs) were observed in a variety of types of colonic neurons. Both spontaneous and stimulus-evoked EPSPs were abolished or suppressed by addition of hexamethonium, tetrodotoxin, or elevation of Mg2+ and reduction of Ca2+ in the bathing medium. Individual neurons usually received inputs from several fiber tracts and multiple EPSPs were sometimes evoked by electrical stimulation of single-fiber tracts. Stimulus-evoked fast EPSPs were always of greater amplitude, longer duration, and longer decay time than were spontaneous fast EPSPs in the same neurons. No rundown of the fast EPSPs occurred during prolonged stimulation at frequencies up to 10 Hz. Repetitive stimulation evoked slow depolarizing potentials (slow EPSPs) in 25% of the neurons. Characteristics of the slow EPSPs were 1) slow rise times, 2) duration in the seconds time domain, 3) enhanced excitability, 4) increased input resistance, and 5) reduction of hyperpolarizing after-potentials. In general, the variety of synaptic potentials and the properties of the events were the same as found in myenteric neurons of the guinea pig small bowel. Compared with synaptic behavior of small intestinal myenteric neurons, the notable differences were absence of the rundown phenomenon for fast EPSPs in the colonic neurons and a greater incidence of spontaneously occurring fast EPSPs.

Purification and characterization of the ouabain-sensitive H+/K+-ATPase from guinea-pig distal colon

2010 ◽  
Vol 496 (1) ◽  
pp. 21-32 ◽  
Author(s):  
Dimas C. Belisario ◽  
Miguel A. Rocafull ◽  
Jesús R. del Castillo
Keyword(s):  
Guinea Pig ◽  
Distal Colon ◽  
Purification And Characterization
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