Evolutionarily conserved organization of the dopaminergic system in lamprey: SNc/VTA afferent and efferent connectivity and D2 receptor expression

2014 ◽  
Vol 522 (17) ◽  
pp. 3775-3794 ◽  
Author(s):  
Juan Pérez-Fernández ◽  
Marcus Stephenson-Jones ◽  
Shreyas M. Suryanarayana ◽  
Brita Robertson ◽  
Sten Grillner
Keyword(s):  
Dopaminergic System ◽  
D2 Receptor ◽  
Receptor Expression ◽  
Evolutionarily Conserved

scholarly journals Evolutionarily conserved organization of the dopaminergic system in lamprey: SNc/VTA afferent and efferent connectivity and D2 receptor expression

2014 ◽  
Vol 522 (17) ◽  
pp. Spc1-Spc1
Author(s):  
Juan Pérez-Fernández ◽  
Marcus Stephenson-Jones ◽  
Shreyas M. Suryanarayana ◽  
Brita Robertson ◽  
Sten Grillner
Keyword(s):  
Dopaminergic System ◽  
D2 Receptor ◽  
Receptor Expression ◽  
Evolutionarily Conserved

Estrogen Deficiency and Colonic Function: Surgical Menopause and Sex Differences in Angiotensin and Dopamine Receptor Interaction

2020 ◽  
Author(s):  
Pablo Garrido-Gil ◽  
Ana I Rodriguez-Perez ◽  
Lucia Lage ◽  
Jose L Labandeira-Garcia
Keyword(s):  
Sex Differences ◽  
Dopamine Receptors ◽  
D2 Receptor ◽  
Renin Angiotensin System ◽  
Receptor Expression ◽  
Oxidative Markers ◽  
Mutual Regulation ◽  
Inflammatory Processes ◽  
Angiotensin Type

Abstract The physiopathological mechanisms that regulate menopausal and sex differences in colonic transit, inflammatory processes, and efficacy of treatments have not been clarified. The dopaminergic system and renin–angiotensin system coexist in the gut and regulate different processes such as motility, absorption/secretion, and inflammation. We investigated the changes in expression of major angiotensin and dopamine receptors in the colon of male, female, and ovariectomized female mice. Possible interaction between both systems was investigated using male and female mice deficient (ko) for major angiotensin and dopamine receptors. In wild-type mice, colonic tissue from females showed lower angiotensin type 1/angiotensin type 2 ratio (an index of pro-inflammatory/anti-inflammatory renin–angiotensin system balance), lower dopamine D1 and D2 receptor expression, and lower levels of pro-inflammatory and pro-oxidative markers relative to males. Interestingly, ovariectomy increased the expression of pro-inflammatory angiotensin type 1 receptor expression and decreased anti-inflammatory angiotensin type 2 receptor expression, increased D1 and D2 receptor expression, and increased the levels of pro-inflammatory and pro-oxidative markers. Ovariectomy-induced changes were blocked by estrogen replacement. The present results suggest a mutual regulation between colonic angiotensin and dopamine receptors and sex differences in this mutual regulation. Estrogen regulates changes in both angiotensin and dopamine receptor expression, which may be involved in sex- and surgical menopause-related effects on gut motility, permeability, and vulnerability to inflammatory processes.

scholarly journals The Biology of Vasopressin

Biomedicines ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 89
Author(s):  
Samantha Sparapani ◽  
Cassandra Millet-Boureima ◽  
Joshua Oliver ◽  
Kathy Mu ◽  
Pegah Hadavi ◽  
...  
Keyword(s):  
Parental Behavior ◽  
Cell Types ◽  
G Protein Coupled Receptors ◽  
Receptor Expression ◽  
Evolutionarily Conserved ◽  
Terrestrial Environments ◽  
Intracellular Vesicles ◽  
G Protein Coupled ◽  
Neuropsychiatric Conditions ◽  
Vasopressin Synthesis

Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response. Vasopressin synthesis in several cell types, storage in intracellular vesicles, and release in response to physiological stimuli are highly regulated and mediated by three distinct G protein coupled receptors. Other receptors may bind or cross-bind vasopressin. Vasopressin is regulated spatially and temporally through transcriptional and post-transcriptional mechanisms, sex, tissue, and cell-specific receptor expression. Anomalies of vasopressin signaling have been observed in polycystic kidney disease, chronic heart failure, and neuropsychiatric conditions. Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists.

Distinct Roles of GluA2-lacking AMPA Receptor Expression in Dopamine D1 or D2 Receptor Neurons in Animal Behavior

Neuroscience ◽  
2019 ◽  
Vol 398 ◽  
pp. 102-112
Author(s):  
Jiayi Shou ◽  
Angelica Tran ◽  
Natasha Snyder ◽  
Eric Bleem ◽  
Seonil Kim
Keyword(s):  
Ampa Receptor ◽  
Animal Behavior ◽  
D2 Receptor ◽  
Receptor Expression ◽  
Receptor Neurons

Dopamine D2 receptor expression in the corticotroph cells of the human normal pituitary gland

Endocrine ◽  
2016 ◽  
Vol 57 (2) ◽  
pp. 314-325 ◽  
Author(s):  
Rosario Pivonello ◽  
Marlijn Waaijers ◽  
Johan M. Kros ◽  
Claudia Pivonello ◽  
Cristina de Angelis ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Expression ◽  
Dopamine D2 ◽  
Normal Pituitary Gland

scholarly journals Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression

2014 ◽  
Vol 8 ◽  
Author(s):  
Anni Richter ◽  
Marc Guitart-Masip ◽  
Adriana Barman ◽  
Catherine Libeau ◽  
Gusalija Behnisch ◽  
...  
Keyword(s):  
Genetic Variant ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Expression ◽  
Dopamine D2 ◽  
Action Inhibition

Dopamine and Migraine: A Review of Pharmacological, Biochemical, Neurophysiological, and Therapeutic Data

Cephalalgia ◽  
1998 ◽  
Vol 18 (4) ◽  
pp. 174-182 ◽  
Author(s):  
A Mascia ◽  
J Qqaacute;fra ◽  
J Schoenen
Keyword(s):  
Dopamine Receptors ◽  
Dopamine Agonists ◽  
Dopaminergic System ◽  
Dopamine D2 Receptor ◽  
Relevant Literature ◽  
D2 Receptor ◽  
Primary Role ◽  
Drd2 Gene ◽  
Dopaminergic Agents ◽  
Migraine Pathogenesis

The dopamine theory of migraine pathogenesis, first proposed by F. Sicuteri in 1977, has attracted renewed interest after an increased frequency of the dopamine D2 receptor (DRD2) gene allele NcoI C was found in patients with migraine with aura. Therefore we reviewed the relevant literature. The most compelling argument favoring an interictal hypersensitivity of dopamine receptors in migraineurs stems from pharmacologic studies of the gastric and autonomic effects of dopaminergic agents such as apomorphine, but none of these studies was blinded and placebo-controlled. Various DRD2 antagonists abort migraine attacks after parenteral administration, while mere is circumstantial evidence that dopamine agonists may be useful for prophylaxis. Most drugs used in these trials, however, lack selectivity for dopamine receptors. Both in pharmacological and therapeutic studies most patients had migraine without aura. We conclude that data suggesting a primary role for the dopaminergic system in migraine pathogenesis are unconvincing. Based on well established interactions between central amines, a reduced release of serotonin between attacks could lower dopamine release which would lead to receptor hypersensitivity.

scholarly journals Intracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alexander Lopachev ◽  
Anna Volnova ◽  
Anna Evdokimenko ◽  
Denis Abaimov ◽  
Yulia Timoshina ◽  
...  
Keyword(s):  
Mouse Model ◽  
Histological Analysis ◽  
Dopaminergic System ◽  
D2 Receptor ◽  
Brain Structures ◽  
Receptor Activation ◽  
Intracerebroventricular Injection ◽  
Fast Scan Cyclic Voltammetry ◽  
The Central Nervous System ◽  
Brain Ventricle

Abstract Intracerebroventricular (ICV) administration of ouabain, an inhibitor of the Na, K-ATPase, is an approach used to study the physiological functions of the Na, K-ATPase and cardiotonic steroids in the central nervous system, known to cause mania-like hyperactivity in rats. We describe a mouse model of ouabain-induced mania-like behavior. ICV administration of 0.5 µl of 50 µM (25 pmol, 14.6 ng) ouabain into each lateral brain ventricle results in increased locomotor activity, stereotypical behavior, and decreased anxiety level an hour at minimum. Fast-scan cyclic voltammetry showed that administration of 50 µM ouabain causes a drastic drop in dopamine uptake rate, confirmed by elevated concentrations of dopamine metabolites detected in the striatum 1 h after administration. Ouabain administration also caused activation of Akt, deactivation of GSK3β and activation of ERK1/2 in the striatum of ouabain-treated mice. All of the abovementioned effects are attenuated by haloperidol (70 µg/kg intraperitoneally). Observed effects were not associated with neurotoxicity, since no dystrophic neuron changes in brain structures were demonstrated by histological analysis. This newly developed mouse model of ouabain-induced mania-like behavior could provide a perspective tool for studying the interactions between the Na,K-ATPase and the dopaminergic system.

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