In vivo parahippocampal white matter pathology as a biomarker of disease progression to Alzheimer's disease

2013 ◽  
Vol 521 (18) ◽  
pp. 4300-4317 ◽  
Author(s):  
Ana Solodkin ◽  
E. Elinor Chen ◽  
Gary W. Van Hoesen ◽  
Lennart Heimer ◽  
Ahmed Shereen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Disease Progression ◽  
White Matter Pathology

Corpus Callosum Measurement as an in Vivo Indicator for Neocortical Neuronal Integrity, but not White Matter Pathology, in Alzheimer's Disease

2000 ◽  
Vol 903 (1 VASCULAR FACT) ◽  
pp. 470-476 ◽  
Author(s):  
HARALD HAMPEL ◽  
STEFAN J. TEIPEL ◽  
GENE E. ALEXANDER ◽  
BARRY HORWITZ ◽  
PIETRO PIETRINI ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Corpus Callosum ◽  
White Matter Pathology

scholarly journals Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Chu Hsien Lim ◽  
Prameet Kaur ◽  
Emelyne Teo ◽  
Vanessa Yuk Man Lam ◽  
Fangchen Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Biological Effects ◽  
Amyloid Β ◽  
Tissue Loss ◽  
Amyloid Β Peptide ◽  
Physical Damage ◽  
Living Tissues

The brains of Alzheimer’s disease patients show a decrease in brain mass and a preponderance of extracellular Amyloid-β plaques. These plaques are formed by aggregation of polypeptides that are derived from the Amyloid Precursor Protein (APP). Amyloid-β plaques are thought to play either a direct or an indirect role in disease progression, however the exact role of aggregation and plaque formation in the aetiology of Alzheimer’s disease (AD) is subject to debate as the biological effects of soluble and aggregated Amyloid-β peptides are difficult to separate in vivo. To investigate the consequences of formation of Amyloid-β oligomers in living tissues, we developed a fluorescently tagged, optogenetic Amyloid-β peptide that oligomerizes rapidly in the presence of blue light. We applied this system to the crucial question of how intracellular Amyloid-β oligomers underlie the pathologies of A. We use Drosophila, C. elegans and D. rerio to show that, although both expression and induced oligomerization of Amyloid-β were detrimental to lifespan and healthspan, we were able to separate the metabolic and physical damage caused by light-induced Amyloid-β oligomerization from Amyloid-β expression alone. The physical damage caused by Amyloid-β oligomers also recapitulated the catastrophic tissue loss that is a hallmark of late AD. We show that the lifespan deficit induced by Amyloid-β oligomers was reduced with Li+ treatment. Our results present the first model to separate different aspects of disease progression.

Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease

2016 ◽  
Vol 146 ◽  
pp. 404-417 ◽  
Author(s):  
Lilian Calderón-Garcidueñas ◽  
Rafael Reynoso-Robles ◽  
Javier Vargas- Martínez ◽  
Aline Gómez-Maqueo-Chew ◽  
Beatriz Pérez-Guillé ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
White Matter ◽  
Mexico City ◽  
Neurovascular Unit ◽  
Potential Impact ◽  
White Matter Pathology

Dissociation between corpus callosum atrophy and white matter pathology in Alzheimer's disease

Neurology ◽  
1998 ◽  
Vol 51 (5) ◽  
pp. 1381-1385 ◽  
Author(s):  
S. J. Teipel ◽  
H. Hampel ◽  
G. E. Alexander ◽  
M. B. Schapiro ◽  
B. Horwitz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Corpus Callosum ◽  
White Matter Pathology

scholarly journals White matter pathology isolates the hippocampal formation in Alzheimer's disease

2010 ◽  
Vol 31 (2) ◽  
pp. 244-256 ◽  
Author(s):  
D.H. Salat ◽  
D.S. Tuch ◽  
A.J.W. van der Kouwe ◽  
D.N. Greve ◽  
V. Pappu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Hippocampal Formation ◽  
White Matter Pathology

scholarly journals What do data‐driven Alzheimer’s disease subtypes tell us about white matter pathology and clinical progression?

2021 ◽  
Vol 17 (S1) ◽  
Author(s):  
Hanyi Chen ◽  
Eric de Silva ◽  
Carole H Sudre ◽  
Jo Barnes ◽  
Alexandra L. Young ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Data Driven ◽  
Clinical Progression ◽  
Disease Subtypes ◽  
White Matter Pathology
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