scholarly journals Efferent connections of the parvalbumin-positive (PV1) nucleus in the lateral hypothalamus of rodents

2013 ◽  
Vol 521 (14) ◽  
pp. Spc1-Spc1
Author(s):  
Marco R. Celio ◽  
Alexandre Babalian ◽  
Quan Hue Ha ◽  
Simone Eichenberger ◽  
Laurence Clément ◽  
...  
Keyword(s):  
Lateral Hypothalamus ◽  
Efferent Connections

scholarly journals Efferent connections of the parvalbumin-positive (PV1) nucleus in the lateral hypothalamus of rodents

2013 ◽  
Vol 521 (14) ◽  
pp. 3133-3153 ◽  
Author(s):  
Marco R. Celio ◽  
Alexandre Babalian ◽  
Quan Hue Ha ◽  
Simone Eichenberger ◽  
Laurence Clément ◽  
...  
Keyword(s):  
Lateral Hypothalamus ◽  
Efferent Connections

scholarly journals The Paraventricular Thalamus as a Critical Node of Motivated Behavior via the Hypothalamic-Thalamic-Striatal Circuit

2021 ◽  
Vol 15 ◽  
Author(s):  
Amanda G. Iglesias ◽  
Shelly B. Flagel
Keyword(s):  
Nucleus Accumbens ◽  
Lateral Hypothalamus ◽  
External Environment ◽  
Glutamatergic Neurons ◽  
Efferent Connections ◽  
Motivated Behavior ◽  
Internal States ◽  
Paraventricular Thalamus ◽  
Motivated Behaviors ◽  
Anterior Posterior

In this review, we highlight evidence that supports a role for the paraventricular nucleus of the thalamus (PVT) in motivated behavior. We include a neuroanatomical and neurochemical overview, outlining what is known of the cellular makeup of the region and its most prominent afferent and efferent connections. We discuss how these connections and distinctions across the anterior-posterior axis correspond to the perceived function of the PVT. We then focus on the hypothalamic-thalamic-striatal circuit and the neuroanatomical and functional placement of the PVT within this circuit. In this regard, the PVT is ideally positioned to integrate information regarding internal states and the external environment and translate it into motivated actions. Based on data that has emerged in recent years, including that from our laboratory, we posit that orexinergic (OX) innervation from the lateral hypothalamus (LH) to the PVT encodes the incentive motivational value of reward cues and thereby alters the signaling of the glutamatergic neurons projecting from the PVT to the shell of the nucleus accumbens (NAcSh). The PVT-NAcSh pathway then modulates dopamine activity and resultant cue-motivated behaviors. As we and others apply novel tools and approaches to studying the PVT we will continue to refine the anatomical, cellular, and functional definitions currently ascribed to this nucleus and further elucidate its role in motivated behaviors.

scholarly journals Research progress on the mechanism of orexin in pain regulation in different brain regions

2021 ◽  
Vol 16 (1) ◽  
pp. 46-52
Author(s):  
Xianhui Kang ◽  
Hongli Tang ◽  
Yao Liu ◽  
Yan Yuan ◽  
Mi Wang
Keyword(s):  
Energy Metabolism ◽  
Acute Pain ◽  
Lateral Hypothalamus ◽  
Brain Regions ◽  
Cardiovascular Control ◽  
Research Progress ◽  
Orexin A ◽  
Physiological Functions ◽  
Pain Transmission ◽  
Pain Regulation

Abstract Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle, and energy metabolism, but also closely associated with various physiological functions, such as cardiovascular control, reproduction, stress, reward, addiction, and the modulation of pain transmission. At present, studies that have been performed both domestically and abroad have confirmed that orexin and its receptors are closely associated with pain regulation. In this article, the research progress on acute pain regulation involving orexin is reviewed.

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