Glucagon-like peptide-1 in the rat brain: Distribution of expression and functional implication

2013 ◽  
Vol 521 (10) ◽  
pp. 2235-2261 ◽  
Author(s):  
Guibao Gu ◽  
Barbara Roland ◽  
Kevin Tomaselli ◽  
Carrie S. Dolman ◽  
Carolyn Lowe ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Distribution ◽  
Functional Implication ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Identification of Glucagon-Like Peptide-1(7–36) Amide in Rat Brain

1989 ◽  
Vol 26 (2) ◽  
pp. 169-171 ◽  
Author(s):  
S Yoshimoto ◽  
M Hirota ◽  
C Ohboshi ◽  
K Shima
Keyword(s):  
Rat Brain ◽  
Anion Exchange ◽  
Gel Filtration ◽  
Anion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Experimental Conditions ◽  
Specific Radioimmunoassay ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
The Brain

Acid-urea extract of rat brain was examined by glucagon-like peptide-1 (GLP-1) specific radioimmunoassay. A single peak was observed which co-eluted with GLP-1(7–36)amide on gel filtration and anion exchange chromatography. In contrast, GLP-1(1–37) was not detected under our experimental conditions. The fact that GLP-1 (7–36)amide, but not GLP-1(1–37), was present in rat brain suggests that preproglucagon was processed in the brain in the same manner as in the intestine and not as in the pancreas.

Identification and Localization of Glucagon-Like Peptide-1 and Its Receptor in Rat Brain*

Endocrinology ◽  
1987 ◽  
Vol 121 (3) ◽  
pp. 1076-1082 ◽  
Author(s):  
ICHIRO SHIMIZU ◽  
MEISEI HIROTA ◽  
CHIZUKO OHBOSHI ◽  
KENJI SHIMA
Keyword(s):  
Rat Brain ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain

Neuropeptides ◽  
1999 ◽  
Vol 33 (3) ◽  
pp. 212-215 ◽  
Author(s):  
J.A. Chowen ◽  
F.Rodrı́guez de Fonseca ◽  
E. Alvarez ◽  
M. Navarro ◽  
L.M. Garcı́a-Segura ◽  
...  
Keyword(s):  
Rat Brain ◽  
Receptor Expression ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Expression of the Glucagon-Like Peptide-1 Receptor Gene in Rat Brain

2002 ◽  
Vol 66 (3) ◽  
pp. 920-927 ◽  
Author(s):  
Elvira Alvarez ◽  
Isabel Roncero ◽  
Julie A. Chowen ◽  
Bernard Thorens ◽  
Enrique Blázquez
Keyword(s):  
Rat Brain ◽  
Receptor Gene ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Identification and characterization of glucagon-like peptide-1 7-36 amide-binding sites in the rat brain and lung

FEBS Letters ◽  
1988 ◽  
Vol 241 (1-2) ◽  
pp. 209-212 ◽  
Author(s):  
Sandip M. Kanse ◽  
Bernhard Kreymann ◽  
Mohammad A. Ghatei ◽  
Stephen R. Bloom
Keyword(s):  
Rat Brain ◽  
Binding Sites ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Identification And Characterization

Autoradiographic localization of receptors for glucagon-like peptide-1(7–36) amide in rat brain

Neuropeptides ◽  
1992 ◽  
Vol 21 (3) ◽  
pp. 143-146 ◽  
Author(s):  
L.O. Uttenthal ◽  
A. Toledano ◽  
E. Blázquez
Keyword(s):  
Rat Brain ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain

2020 ◽  
Author(s):  
Erzsébet Farkas ◽  
Anett Szilvásy-Szabó ◽  
Yvette Ruska ◽  
Richárd Sinkó ◽  
Morten Grønbech Rasch ◽  
...  
Keyword(s):  
Rat Brain ◽  
Energy Homeostasis ◽  
Ultrastructural Localization ◽  
Circumventricular Organs ◽  
High Concentration ◽  
Electron Microscopic ◽  
Axon Terminals ◽  
Brain Functions ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

AbstractGlucagon-like peptide-1 (GLP-1) inhibits food intake and regulates glucose homeostasis. These actions are at least partly mediated by central GLP-1 receptor (GLP-1R). Little information is available, however, about the subcellular localization and the distribution of the GLP-1R protein in the rat brain. To determine the localization of GLP-1R protein in the rat brain, immunocytochemistry was performed at light and electron microscopic levels. The highest density of GLP-1R-immunoreactivity was observed in the circumventricular organs and regions in the vicinity of these areas like in the arcuate nucleus (ARC) and in the nucleus tractus solitarii (NTS). In addition, GLP-1R-immunreactive (IR) neuronal profiles were also observed in a number of telencephalic, diencephalic and brainstem areas and also in the cerebellum. Ultrastructural examination of GLP-1R-immunoreactivity in energy homeostasis related regions showed that GLP-1R immunoreactivity is associated with the membrane of perikarya and dendrites but GLP-1R can also be observed inside and on the surface of axon varicosities and axon terminals. In conclusion, in this study we provide a detailed map of the GLP-1R-IR structures in the CNS. Furthermore, we demonstrate that in addition to the perikaryonal and dendritic distribution, GLP-1R is also present in axonal profiles suggesting a presynaptic action of GLP-1. The very high concentration of GLP-1R-profiles in the circumventricular organs and in the ARC and NTS suggests that peripheral GLP-1 may influence brain functions via these brain areas.

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