A multisensory centrifugal neuron in the olfactory pathway of heliothine moths

2012 ◽  
Vol 521 (1) ◽  
pp. 152-168 ◽  
Author(s):  
Xin-Cheng Zhao ◽  
Gerit Pfuhl ◽  
Annemarie Surlykke ◽  
Jan Tro ◽  
Bente G. Berg
Keyword(s):  
Olfactory Pathway ◽  
Heliothine Moths

Proboscis lateralis with ipsilateral sinonasal and olfactory pathway aplasia

2010 ◽  
Vol 45 (2) ◽  
pp. 453-456 ◽  
Author(s):  
Sanjay Vaid ◽  
Darshan Shah ◽  
Sudarshan Rawat ◽  
Rahul Shukla
Keyword(s):  
Olfactory Pathway ◽  
Proboscis Lateralis

scholarly journals Developmental regulation of antennal formation in Heliothine moths

2009 ◽  
Vol 331 (2) ◽  
pp. 488-489
Author(s):  
Kristy L. Kenyon ◽  
Kathy Poole ◽  
Callie Musto ◽  
Charles E. Linn ◽  
Wendell L. Roelofs ◽  
...  
Keyword(s):  
Developmental Regulation ◽  
Heliothine Moths

Electrophysiology of the olfactory pathway in the pigeon

1980 ◽  
Vol 137 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Angelica W. Macadar ◽  
Lyle J. Rausch ◽  
Bernice M. Wenzel ◽  
Larry V. Hutchison
Keyword(s):  
Olfactory Pathway

The Olfactory Pathway as a Model Cerebral System

1975 ◽  
pp. 137-143
Author(s):  
F. L. Margolis ◽  
A. Keller ◽  
D. Ferriero
Keyword(s):  
Olfactory Pathway

scholarly journals Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1904
Author(s):  
Frank Maigler ◽  
Simone Ladel ◽  
Johannes Flamm ◽  
Stella Gänger ◽  
Barbara Kurpiers ◽  
...  
Keyword(s):  
Olfactory Mucosa ◽  
Brain Targeting ◽  
Olfactory Pathway ◽  
Delivery Methods ◽  
Major Drawback ◽  
Delivery Technique ◽  
Clinical Potential ◽  
Refined Technique ◽  
Murine Igg1

Intranasal drug delivery is a promising approach for the delivery of drugs to the CNS, but too heterogenous, unprecise delivery methods without standardization decrease the quality of many studies in rodents. Thus, the lack of a precise and region-specific application technique for mice is a major drawback. In this study, a previously developed catheter-based refined technique was validated against the conventional pipette-based method and used to specifically reach the olfactory or the respiratory nasal regions. This study successfully demonstrated region-specific administration at the olfactory mucosa resulting in over 20% of the administered fluorescein dose in the olfactory bulbs, and no peripheral bioactivity of insulin detemir and Fc-dependent uptake of two murine IgG1 (11C7 and P3X) along the olfactory pathway to cortex and hippocampus. An scFv of 11C7 showed hardly any uptake to the CNS. Elimination was dependent on the presence of the IgG’s antigen. In summary, it was successfully demonstrated that region-specific intranasal administration via the olfactory region resulted in improved brain targeting and reduced peripheral targeting in mice. The data are discussed with regard to their clinical potential.

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