Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy

2012 ◽  
Vol 520 (7) ◽  
pp. 1387-1405 ◽  
Author(s):  
Kornél Lefkovics ◽  
Mátyás Mayer ◽  
Kinga Bercsényi ◽  
Gábor Szabó ◽  
Zsolt Lele
Keyword(s):  
Comparative Analysis ◽  
Somatosensory Cortex ◽  
Adult Mouse ◽  
Distribution Patterns ◽  
Functional Redundancy ◽  
Type Ii

scholarly journals Comparative Analysis of the Frequency and Distribution of Stem and Progenitor Cells in the Adult Mouse Brain

Stem Cells ◽  
2008 ◽  
Vol 26 (4) ◽  
pp. 979-987 ◽  
Author(s):  
Mohammad G. Golmohammadi ◽  
Daniel G. Blackmore ◽  
Beatrice Large ◽  
Hassan Azari ◽  
Ebrahim Esfandiary ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Progenitor Cells ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Adult Mouse Brain ◽  
Stem And Progenitor Cells

scholarly journals Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A

2020 ◽  
Vol 117 (49) ◽  
pp. 30907-30917 ◽  
Author(s):  
Se-Jin Lee ◽  
Adam Lehar ◽  
Yewei Liu ◽  
Chi Hai Ly ◽  
Quynh-Mai Pham ◽  
...  
Keyword(s):  
Family Member ◽  
Muscle Mass ◽  
Transforming Growth Factor ◽  
Muscle Growth ◽  
Functional Redundancy ◽  
Activin A ◽  
Metabolic Effects ◽  
Type I ◽  
Type Ii

Myostatin (MSTN) is a transforming growth factor-β (TGF-β) family member that normally acts to limit muscle growth. The function of MSTN is partially redundant with that of another TGF-β family member, activin A. MSTN and activin A are capable of signaling through a complex of type II and type I receptors. Here, we investigated the roles of two type II receptors (ACVR2 and ACVR2B) and two type I receptors (ALK4 and ALK5) in the regulation of muscle mass by these ligands by genetically targeting these receptors either alone or in combination specifically in myofibers in mice. We show that targeting signaling in myofibers is sufficient to cause significant increases in muscle mass, showing that myofibers are the direct target for signaling by these ligands in the regulation of muscle growth. Moreover, we show that there is functional redundancy between the two type II receptors as well as between the two type I receptors and that all four type II/type I receptor combinations are utilized in vivo. Targeting signaling specifically in myofibers also led to reductions in overall body fat content and improved glucose metabolism in mice fed either regular chow or a high-fat diet, demonstrating that these metabolic effects are the result of enhanced muscling. We observed no effect, however, on either bone density or muscle regeneration in mice in which signaling was targeted in myofibers. The latter finding implies that MSTN likely signals to other cells, such as satellite cells, in addition to myofibers to regulate muscle homeostasis.

scholarly journals An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512

2015 ◽  
Vol 51 (76) ◽  
pp. 14310-14313 ◽  
Author(s):  
Giulia Palermo ◽  
Elirosa Minniti ◽  
Maria Laura Greco ◽  
Laura Riccardi ◽  
Elena Simoni ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Type Ii ◽  
Human Type ◽  
Topoisomerase Poisons ◽  
Experimental Analyses ◽  
Clinical Candidate

Computational–experimental analyses explain F14512's boosted potency as a topoII poison.

scholarly journals Comparative analysis ofSix3andSix6distribution in the developing and adult mouse brain

2005 ◽  
Vol 234 (3) ◽  
pp. 718-725 ◽  
Author(s):  
Ivan Conte ◽  
Julian Morcillo ◽  
Paola Bovolenta
Keyword(s):  
Comparative Analysis ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Adult Mouse Brain
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