scholarly journals The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Haruhito Horita ◽  
Kazuhiro Wada ◽  
Miriam Rivas ◽  
Erina Hara ◽  
Erich D. Jarvis
Keyword(s):  
Sensory Input ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Natural Stimuli

scholarly journals Experience-dependent plasticity in accessory olfactory bulb interneurons following male-male social interaction

2017 ◽  
Author(s):  
Hillary L. Cansler ◽  
Marina A. Maksimova ◽  
Julian P. Meeks
Keyword(s):  
Olfactory Bulb ◽  
Sensory Input ◽  
Granule Cells ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Intrinsic Excitability ◽  
Accessory Olfactory Bulb ◽  
Dependent Plasticity ◽  
Resident Intruder

AbstractChemosensory information processing in the mouse accessory olfactory system (AOS) guides the expression of social behavior. After salient chemosensory encounters, the accessory olfactory bulb (AOB) experiences changes in the balance of excitation and inhibition at reciprocal synapses between mitral cells (MCs) and local interneurons. The mechanisms underlying these changes remain controversial. Moreover, it remains unclear whether MC-interneuron plasticity is unique to specific behaviors, such as mating, or whether it is a more general feature of the AOB circuit. Here, we describe targeted electrophysiological studies of AOB inhibitory internal granule cells (IGCs), many of which upregulate the immediate-early gene Arc after male-male social experience. Following the resident-intruder paradigm, Arc-expressing IGCs in acute AOB slices from resident males displayed stronger excitation than non-expressing neighbors when sensory inputs are stimulated. The increased excitability of Arc-expressing IGCs was not correlated with changes in the strength or number of excitatory synapses with MCs, but was instead associated with increased intrinsic excitability and decreased HCN channel-mediated IH currents. Consistent with increased inhibition by IGCs, MCs responded to sensory input stimulation with decreased depolarization and spiking following resident-intruder encounters. These results reveal that non-mating behaviors drive AOB inhibitory plasticity, and indicate that increased MC inhibition involves intrinsic excitability changes in Arc-expressing interneurons.Significance StatementThe accessory olfactory bulb (AOB) is a site of experience-dependent plasticity between excitatory mitral cells (MCs) and inhibitory internal granule cells (IGCs), but the physiological mechanisms and behavioral conditions driving this plasticity remain unclear. Here, we report studies of AOB neuronal plasticity following male-male social chemosensory encounters. We show that the plasticity-associated immediate-early gene Arc is selectively expressed in IGCs from resident males following the resident-intruder assay. After behavior, Arc- expressing IGCs are more strongly excited by sensory input stimulation and MC activation is suppressed. Arc-expressing IGCs do not show increased excitatory synaptic drive, but instead show increased intrinsic excitability. These data indicate that MC-IGC plasticity is induced after male-male social chemosensory encounters, resulting in enhanced MC suppression by Arc-expressing IGCs.

Phylogenetic relatedness and immediate early gene expression in black-capped chickadees

2012 ◽  
Author(s):  
Christopher B. Sturdy ◽  
Marc T. Avey ◽  
Laurie L. Bloomfield ◽  
Julie E. Elie ◽  
Todd M. Freeberg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Phylogenetic Relatedness ◽  
Early Gene Expression

scholarly journals Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells

2004 ◽  
Vol 557 (3) ◽  
pp. 773-783 ◽  
Author(s):  
Guoxiang Yuan ◽  
Gautam Adhikary ◽  
Andrew A. McCormick ◽  
John. J. Holcroft ◽  
Ganesh K. Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Intermittent Hypoxia ◽  
Gene Activation ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early
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