Differential localization of γ-aminobutyric acid type a and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: An immunohistochemical study

2010 ◽  
Vol 518 (3) ◽  
pp. 305-328 ◽  
Author(s):  
H.J. Waldvogel ◽  
K. Baer ◽  
E. Eady ◽  
K.L. Allen ◽  
R.T. Gilbert ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Medulla Oblongata ◽  
Immunohistochemical Study ◽  
Glycine Receptor ◽  
Type A ◽  
Aminobutyric Acid ◽  
Acid Type ◽  
Cervical Segment ◽  
Differential Localization ◽  
Pons Medulla

The Plasticizer Di(2-ethylhexyl) Phthalate Modulates ??-Aminobutyric Acid Type A and Glycine Receptor Function

2007 ◽  
Vol 105 (2) ◽  
pp. 393-396 ◽  
Author(s):  
Liya Yang ◽  
Pavle S. Milutinovic ◽  
Robert J. Brosnan ◽  
Edmond I Eger ◽  
James M. Sonner
Keyword(s):  
Glycine Receptor ◽  
Type A ◽  
Aminobutyric Acid ◽  
Receptor Function ◽  
Acid Type ◽  
Ethylhexyl Phthalate

scholarly journals Gephyrin-mediated γ-Aminobutyric Acid Type A and Glycine Receptor Clustering Relies on a Common Binding Site

2011 ◽  
Vol 286 (49) ◽  
pp. 42105-42114 ◽  
Author(s):  
Hans-Michael Maric ◽  
Jayanta Mukherjee ◽  
Verena Tretter ◽  
Stephen J. Moss ◽  
Hermann Schindelin
Keyword(s):  
Binding Site ◽  
Glycine Receptor ◽  
Type A ◽  
Aminobutyric Acid ◽  
Receptor Clustering ◽  
Acid Type

scholarly journals Neural Mechanisms of Sevoflurane-induced Respiratory Depression in Newborn Rats

2008 ◽  
Vol 109 (2) ◽  
pp. 233-242 ◽  
Author(s):  
Junya Kuribayashi ◽  
Shigeki Sakuraba ◽  
Masanori Kashiwagi ◽  
Eiki Hatori ◽  
Miki Tsujita ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Respiratory Depression ◽  
Motor Neurons ◽  
Type A ◽  
Aminobutyric Acid ◽  
Respiratory Neurons ◽  
Gamma Aminobutyric Acid ◽  
Inspiratory Neurons ◽  
Acid Type ◽  
Bötzinger Complex

Background Sevoflurane-induced respiratory depression has been reported to be due to the action on medullary respiratory and phrenic motor neurons. These results were obtained from extracellular recordings of the neurons. Here, the authors made intracellular recordings of respiratory neurons and analyzed their membrane properties during sevoflurane application. Furthermore, they clarified the role of gamma-aminobutyric acid type A receptors in sevoflurane-induced respiratory depression. Methods In the isolated brainstem-spinal cord of newborn rat, the authors recorded the C4 nerve burst as an index of inspiratory activity. The preparation was superfused with a solution containing sevoflurane alone or sevoflurane plus the gamma-aminobutyric acid type A receptor antagonist picrotoxin or bicuculline. Neuronal activities were also recorded using patch clamp techniques. Results Sevoflurane decreased C4 burst rate and amplitude. Separate perfusion of sevoflurane to the medulla and to the spinal cord decreased C4 burst rate and amplitude, respectively. Both picrotoxin and bicuculline attenuated the reduction of C4 burst rate. Sevoflurane reduced both intraburst firing frequency and membrane resistance of respiratory neurons except for inspiratory neurons. Conclusion Under the influence of sevoflurane, the region containing inspiratory neurons, i.e., the pre-Bötzinger complex, may determine the inspiratory rhythm, because reduced C4 bursts were still synchronized with the bursts of inspiratory neurons within the pre-Bötzinger complex. In contrast, the sevoflurane-induced decrease in C4 burst amplitude is mediated through the inhibition of phrenic motor neurons. gamma-Aminobutyric acid type A receptors may be involved in the sevoflurane-induced respiratory depression within the medulla, but not within the spinal cord.

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