Pattern of long-term sensorimotor recovery following intrastriatal and -accumbens DA micrografts in a rat model of Parkinson's disease

2009 ◽  
Vol 515 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Gero Falkenstein ◽  
Christoph Rosenthal ◽  
Torsten Reum ◽  
Rudolf Morgenstern ◽  
Máté Döbrössy ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Sensorimotor Recovery

Long-Term Survival of Human Central Nervous System Progenitor Cells Transplanted into a Rat Model of Parkinson's Disease

1997 ◽  
Vol 148 (1) ◽  
pp. 135-146 ◽  
Author(s):  
Clive N. Svendsen ◽  
Maeve A. Caldwell ◽  
Jinkun Shen ◽  
Melanie G. ter Borg ◽  
Anne E. Rosser ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Central Nervous System ◽  
Parkinson's Disease ◽  
Nervous System ◽  
Progenitor Cells ◽  
Rat Model ◽  
Human Central Nervous System ◽  
Term Survival ◽  
Long Term Survival

Long-Term Survival of Porcine Expanded Neural Precursors in the Rat Model of Parkinson's Disease

2002 ◽  
Vol 103 (s47) ◽  
pp. 67P-67P
Author(s):  
T. Harrower ◽  
E. Ratcliffe ◽  
A Richards ◽  
S. Dunnett ◽  
R. Bark
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Term Survival ◽  
Neural Precursors ◽  
Long Term Survival

scholarly journals Nitric Oxide-Containing Neurons in Long-Term Grafts in a Rat Model of Parkinson's Disease

2007 ◽  
Vol 16 (5) ◽  
pp. 449-459 ◽  
Author(s):  
B. Rajakumar ◽  
B. A. Flumerfelt ◽  
A. W. Hrycyshyn ◽  
N. Rajakumar
Keyword(s):  
Nitric Oxide ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model

Long-term correction of rat model of Parkinson's disease by gene therapy

Nature ◽  
1993 ◽  
Vol 362 (6419) ◽  
pp. 450-453 ◽  
Author(s):  
Shoushu Jiao ◽  
Vladimir Gurevich ◽  
Jon A. Wolff
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Rat Model

Long-term effect of intra-striatal glial cell line-derived neurotrophic factor-releasing microspheres in a partial rat model of Parkinson's disease

2004 ◽  
Vol 356 (3) ◽  
pp. 207-210 ◽  
Author(s):  
Christophe Jollivet ◽  
Anne Aubert-Pouessel ◽  
Anne Clavreul ◽  
Marie-Claire Venier-Julienne ◽  
Claudia N. Montero-Menei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Line ◽  
Glial Cell ◽  
Rat Model ◽  
Neurotrophic Factor ◽  
Term Effect ◽  
Long Term Effect

scholarly journals Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Wan-Ling Tsai ◽  
Hsin-Yung Chen ◽  
Ying-Zu Huang ◽  
Yuan-Hao Chen ◽  
Chi-Wei Kuo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Locomotor Activity ◽  
Physical Exercise ◽  
Rat Model ◽  
Dopaminergic Neuron ◽  
Gait Pattern ◽  
Exercise Group ◽  
Neuroprotective Effects

Background. Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder affecting 7–10 million individuals. The pathologic hallmark of PD is nigrostriatal dopaminergic neuron loss, leading to several motor and nonmotor disturbances, such as akinesia, gait disturbance, depression, and anxiety. Recent animal studies have demonstrated that physical exercise improves behavioral and neuropathological deficits in PD. However, the exact underlying mechanism underlying this effect remains unclear. In this study, we investigated whether long-term exercise has neuroprotective effects on dopaminergic nigrostriatal neurons and whether it further alleviates impairment of the gait pattern, locomotor activity, akinesia, and anxiety-like behavior in PD rats. Methods. A hemiparkinsonian rat model, generated by unilateral injection of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle, was applied to evaluate neuroprotective effects and motor behaviors. Comprehensive spatiotemporal gait analysis, open-field locomotor activity, akinesia, apomorphine-induced rotational analysis, and dopaminergic neuron degeneration level were assessed every week and up to 8 weeks after daily voluntary running wheel exercise. Results. Compared with the sham-treated group, we found that 10 weeks of voluntary exercise (i.e., 2-week exercise before PD lesion and 8-week exercise post-PD lesion) significantly reduced 6-OHDA-induced motor deficits in the gait pattern, akinesia, and rotational behavior in the exercise group. Immunohistochemically, a tyrosine hydroxylase-positive neuron in the substantia nigra was significantly preserved in the exercise group. Conclusions. Our results demonstrated that long-term exercise training is effective for neuroprotection and further attenuates motor declines induced by 6-OHDA in an experimental model of PD. Our data further highlighted potential therapeutic effects of long-term physical exercise relevant to clinical effects for further potential application on human PD subjects.

Erratum: Long-term correction of rat model of Parkinson's disease by gene therapy

Nature ◽  
1996 ◽  
Vol 380 (6576) ◽  
pp. 734-734 ◽  
Author(s):  
Shoushu Jiao ◽  
Vladimir Gurevich ◽  
Jon A. Wolff
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Rat Model
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