Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats

2009 ◽  
Vol 514 (5) ◽  
pp. 433-448 ◽  
Author(s):  
Thomas Pang Lo ◽  
Kyoung-Suok Cho ◽  
Maneesh Sen Garg ◽  
Michael Patrick Lynch ◽  
Alexander Eduardo Marcillo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Functional Outcome ◽  
Cervical Spinal Cord ◽  
Systemic Hypothermia ◽  
Spinal Cord Contusion

Modulation of the extrinsic tongue muscle activity in response to bronchopulmonary C-fiber activation following midcervical contusion in the rat

2020 ◽  
Vol 128 (5) ◽  
pp. 1130-1145
Author(s):  
Hsiao-Sen Chang ◽  
Kun-Ze Lee
Keyword(s):  
Spinal Cord ◽  
Muscle Activity ◽  
Cervical Spinal Cord ◽  
Upper Airway ◽  
Airway Patency ◽  
Tongue Muscle ◽  
Cord Injury ◽  
Burst Amplitude ◽  
C Fiber ◽  
Spinal Cord Contusion

Tongue muscle activity plays an important role in the regulation of upper airway patency. This study aimed to investigate the respiratory activity of the extrinsic tongue muscle in response to capsaicin-induced bronchopulmonary C-fiber activation following cervical spinal cord contusion. Midcervical spinal-contused animals exhibited a greater baseline preinspiratory burst amplitude of the extrinsic tongue muscle and were resistant to inhaled capsaicin-induced reduction of respiratory tongue muscle activity at the acute injured stage. However, inhalation of capsaicin caused a more severe attenuation of preinspiratory activity of the extrinsic tongue muscle at the chronic injured stage. These results suggest that the upper airway may be predisposed to collapse in response to bronchopulmonary C-fiber activation following chronic cervical spinal cord injury.

scholarly journals Early Phrenic Motor Neuron Loss and Transient Respiratory Abnormalities after Unilateral Cervical Spinal Cord Contusion

2013 ◽  
Vol 30 (12) ◽  
pp. 1092-1099 ◽  
Author(s):  
Charles Nicaise ◽  
David M. Frank ◽  
Tamara J. Hala ◽  
Michèle Authelet ◽  
Roland Pochet ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Neuron ◽  
Cervical Spinal Cord ◽  
Neuron Loss ◽  
Motor Neuron Loss ◽  
Spinal Cord Contusion

scholarly journals Rodent Neural Progenitor Cells Support Functional Recovery after Cervical Spinal Cord Contusion

2018 ◽  
Vol 35 (9) ◽  
pp. 1069-1078 ◽  
Author(s):  
John Hoffman Brock ◽  
Lori Graham ◽  
Eileen Staufenberg ◽  
Sarah Im ◽  
Mark Henry Tuszynski
Keyword(s):  
Spinal Cord ◽  
Progenitor Cells ◽  
Functional Recovery ◽  
Neural Progenitor Cells ◽  
Cervical Spinal Cord ◽  
Neural Progenitor ◽  
Support Functional ◽  
Spinal Cord Contusion

scholarly journals 5-HT7 Receptor Inhibition Transiently Improves Respiratory Function Following Daily Acute Intermittent Hypercapnic-Hypoxia in Rats With Chronic Midcervical Spinal Cord Contusion

2020 ◽  
Vol 34 (4) ◽  
pp. 333-343
Author(s):  
Ming-Jane Wu ◽  
Stéphane Vinit ◽  
Chun-Lin Chen ◽  
Kun-Ze Lee
Keyword(s):  
Spinal Cord ◽  
Tidal Volume ◽  
Dimethyl Sulfoxide ◽  
Respiratory Function ◽  
Cervical Spinal Cord ◽  
Daily Basis ◽  
Receptor Inhibition ◽  
Cord Injury ◽  
Hypercapnic Hypoxia ◽  
Spinal Cord Contusion

Background. Intermittent hypoxia can induce respiratory neuroplasticity to enhance respiratory motor outputs following hypoxic treatment. This type of respiratory neuroplasticity is primarily mediated by the activation of Gq-protein-coupled 5-HT2 receptors and constrained by Gs-protein-coupled 5-HT7 receptors. Objective. The present study hypothesized that the blockade of 5-HT7 receptors can potentiate the effect of intermittent hypercapnic-hypoxia on respiratory function after cervical spinal cord contusion injury. Methods. The ventilatory behaviors of unanesthetized rats with midcervical spinal cord contusions were measured before, during, and after daily acute intermittent hypercapnic-hypoxia (10 episodes of 5 minutes of hypoxia [10% O2, 4% CO2, 86% N2] with 5 minutes of normoxia intervals for 5 days) at 8 weeks postinjury. On a daily basis, 5 minutes before intermittent hypercapnic-hypoxia, rats received either a 5-HT7 receptor antagonist (SB269970, 4 mg/kg, intraperitoneal) or a vehicle (dimethyl sulfoxide). Results. Treatment with intermittent hypercapnic-hypoxia induced a similar increase in tidal volume between rats that received SB269970 and those that received dimethyl sulfoxide within 60 minutes post-hypoxia on the first day. However, after 2 to 3 days of daily acute intermittent hypercapnic-hypoxia, the baseline tidal volumes of rats treated with SB269970 increased significantly. Conclusions. These results suggest that inhibiting the 5-HT7 receptor can transiently improve daily intermittent hypercapnic-hypoxia–induced tidal volume increase in midcervical spinal contused animals. Therefore, combining pharmacological treatment with rehabilitative intermittent hypercapnic-hypoxia training may be an effective strategy for synergistically enhancing respiratory neuroplasticity to improve respiratory function following chronic cervical spinal cord injury.

scholarly journals A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta)

2016 ◽  
Vol 33 (5) ◽  
pp. 439-459 ◽  
Author(s):  
Ernesto A. Salegio ◽  
Jacqueline C. Bresnahan ◽  
Carolyn J. Sparrey ◽  
William Camisa ◽  
Jason Fischer ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Macaca Mulatta ◽  
Cervical Spinal Cord ◽  
Injury Model ◽  
Contusion Injury ◽  
Spinal Cord Contusion
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