Fibroblast growth factor homologous factor 1 (FHF1) is expressed in a subpopulation of calcitonin gene-related peptide-positive nociceptive neurons in the murine dorsal root ganglia

2008 ◽  
Vol 507 (4) ◽  
pp. 1588-1601 ◽  
Author(s):  
Thomas Hubert ◽  
Steeve Bourane ◽  
Stéphanie Ventéo ◽  
Ilana Mechaly ◽  
Sylvie Puech ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Calcitonin Gene Related Peptide ◽  
Fibroblast Growth ◽  
Nociceptive Neurons ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Regulation of Calcitonin Gene-Related Peptide Expression in Dorsal Root Ganglia of Rats by Female Sex Steroid Hormones1

2000 ◽  
Vol 62 (4) ◽  
pp. 1033-1039 ◽  
Author(s):  
P.R.R. Gangula ◽  
P. Lanlua ◽  
S. Wimalawansa ◽  
S. Supowit ◽  
D. DiPette ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Calcitonin Gene Related Peptide ◽  
Sex Steroid ◽  
Related Peptide ◽  
Female Sex ◽  
Calcitonin Gene ◽  
Peptide Expression

scholarly journals Evaluation of Histological Changes in Back Muscle Injuries in Rats over Time

2017 ◽  
Vol 11 (1) ◽  
pp. 88-92 ◽  
Author(s):  
Koki Abe ◽  
Kazuhide Inage ◽  
Yoshihiro Sakuma ◽  
Sumihisa Orita ◽  
Kazuyo Yamauchi ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Calcitonin Gene Related Peptide ◽  
Histological Evaluation ◽  
Back Muscle ◽  
Paravertebral Muscle ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
The Right ◽  
Over Time

<sec><title>Study Design</title><p>Animal model study.</p></sec><sec><title>Purpose</title><p>The purpose of this study was to evaluate the histological variation in the injured muscle and production of calcitonin gene-related peptide in rats over time.</p></sec><sec><title>Overview of Literature</title><p>Vertebral surgery has been reported to cause atrophy of the back muscles, which may result in pain. However, few reports have described the time series histological variation in the injured muscle and changes in the dominant nerve.</p></sec><sec><title>Methods</title><p>We used 30 male, 8-week-old Sprague-Dawley rats. The right and left sides of the paravertebral muscle were considered as the injured and uninjured sides, respectively. A 115 g weight was dropped from a height of 1 m on the right paravertebral muscle. Hematoxylin and eosin (H&amp;E) staining of the muscle was performed 1–3 weeks after injury for histological evaluation. Fluoro-Gold (FG) was injected into the paravertebral muscle. The L2 dorsal root ganglia on both sides were resected 1, 2, and 3 weeks after injury, and immunohistochemical staining for calcitonin gene-related peptide was performed.</p></sec><sec><title>Results</title><p>H&amp;E staining of the paravertebral muscle showed infiltration of inflammatory cells and the presence of granulation tissue in the injured part on the ipsilateral side 1 week after injury. Muscle atrophy occurred 3 weeks after injury, but was repaired via spontaneous replacement of muscle cells/fibers. In contrast, compared with the uninjured side, the percentage of cells double-labeled with FG and calcitonin gene-related peptide in FG-positive cells in the dorsal root ganglia of the injured side was significantly increased at each time point throughout the study period.</p></sec><sec><title>Conclusions</title><p>These results suggest that sensitization of the dominant nerve in the dorsal root ganglia, which may be caused by cicatrix formation, can protract injured muscle pain. This information may be helpful in elucidating the underlying mechanism of persistent pain after back muscle injury.</p></sec>

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