Displaced amacrine cells of the mouse retina

2007 ◽  
Vol 505 (2) ◽  
pp. 177-189 ◽  
Author(s):  
Luis Pérez De Sevilla Müller ◽  
Jennifer Shelley ◽  
Reto Weiler
Keyword(s):  
Amacrine Cells ◽  
Mouse Retina ◽  
Displaced Amacrine Cells

scholarly journals Glycinergic input of widefield, displaced amacrine cells of the mouse retina

2009 ◽  
Vol 587 (15) ◽  
pp. 3831-3849 ◽  
Author(s):  
Sriparna Majumdar ◽  
Jan Weiss ◽  
Heinz Wässle
Keyword(s):  
Amacrine Cells ◽  
Mouse Retina ◽  
Displaced Amacrine Cells

scholarly journals Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina

2005 ◽  
Vol 94 (6) ◽  
pp. 1739-1745 ◽  
Author(s):  
Lee Stewart ◽  
Mary Anne Potok ◽  
Sally A. Camper ◽  
Stefano Stifani
Keyword(s):  
Amacrine Cells ◽  
Mouse Retina ◽  
Displaced Amacrine Cells ◽  
Runx1 Expression

Expression and modulation of connexin30.2, a novel gap junction protein in the mouse retina

2010 ◽  
Vol 27 (3-4) ◽  
pp. 91-101 ◽  
Author(s):  
LUIS PÉREZ DE SEVILLA MÜLLER ◽  
KARIN DEDEK ◽  
ULRIKE JANSSEN-BIENHOLD ◽  
ARNDT MEYER ◽  
MARIA M. KREUZBERG ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Gap Junction ◽  
Ganglion Cells ◽  
Electrical Coupling ◽  
Amacrine Cells ◽  
Mouse Retina ◽  
Coding Region ◽  
Transgenic Mouse Line ◽  
Junction Protein ◽  
Displaced Amacrine Cells

AbstractMammalian retinae express multiple connexins that mediate the metabolic and electrical coupling of various cell types. In retinal neurons, only connexin36, connexin45, connexin50, and connexin57 have been described so far. Here, we present an analysis of a novel retinal connexin, connexin30.2 (Cx30.2), and its regulation in the mouse retina. To analyze the expression of Cx30.2, we used a transgenic mouse line in which the coding region of Cx30.2 was replaced by lacZ reporter DNA. We detected the lacZ signal in the nuclei of neurons located in the inner nuclear layer and the ganglion cell layer (GCL). In this study, we focused on the GCL and characterized the morphology of the Cx30.2-expressing cells. Using immunocytochemistry and intracellular dye injections, we found six different types of Cx30.2-expressing ganglion cells: one type of ON-OFF, three types of OFF, and two types of ON ganglion cells; among the latter was the RGA1 type. We show that RGA1 cells were heterologously coupled to numerous displaced amacrine cells. Our results suggest that these gap junction channels may be heterotypic, involving Cx30.2 and a connexin yet unidentified in the mouse retina. Gap junction coupling can be modulated by protein kinases, a process that plays a major role in retinal adaptation. Therefore, we studied the protein kinase–induced modulation of coupling between RGA1 and displaced amacrine cells. Our data provide evidence that coupling of RGA1 cells to displaced amacrine cells is mediated by Cx30.2 and that the extent of this coupling is modulated by protein kinase C.

scholarly journals DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina

2010 ◽  
Vol 348 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Ming Shi ◽  
Min-Hua Zheng ◽  
Zhi-Rong Liu ◽  
Ze-Lan Hu ◽  
Ying Huang ◽  
...  
Keyword(s):  
Amacrine Cells ◽  
Mouse Retina ◽  
Retinal Ganglion ◽  
Displaced Amacrine Cells

Modulation by Zn2+ of GABA responses in bipolar cells of the mouse retina

2000 ◽  
Vol 17 (2) ◽  
pp. 273-281 ◽  
Author(s):  
M. KANEDA ◽  
B. ANDRÁSFALVY ◽  
A. KANEKO
Keyword(s):  
Axon Terminal ◽  
Inhibitory Action ◽  
Phosphinic Acid ◽  
Amacrine Cells ◽  
Bipolar Cells ◽  
Mouse Retina ◽  
Induced Responses ◽  
Inhibitory Interaction ◽  
Cell Recording ◽  
Recording Conditions

The localization of endogenous Zn2+ in the mouse retina was examined histochemically and the inhibitory action of Zn2+ on GABA-induced responses was studied in bipolar cells isolated from the mouse retina. Accumulation of endogenous Zn2+ was detected in photoreceptors, bipolar, and/or amacrine cells by either the bromopyridylazo-diethylaminophenol method or the dithizone method. Under whole-cell recording conditions, GABA induced a Cl− current in isolated bipolar cells. The current consisted of two components. The first component was inhibited completely by application of 100 μM bicuculline, suggesting that this is a GABAA-receptor mediated current. The second component was inhibited completely by 100 μM 3-aminopropyl-(methyl)-phosphinic acid, suggesting that this is a GABAC-receptor mediated current. GABAC receptors were present at a higher density on the axon terminal than on dendrites. Zn2+ inhibited both GABAA and GABAC receptors. GABAC receptors were more susceptible to Zn2+; the IC50 for the GABAA receptor was 67.4 μM and that for the GABAC receptor was 1.9 μM. These results suggest that Zn2+ modulates the inhibitory interaction between amacrine and bipolar cells, particularly that mediated by the GABAC receptor.

The retinal ganglion cell distribution and the representation of the visual field in area 17 of the owl monkey, Aotus trivirgatus

1993 ◽  
Vol 10 (5) ◽  
pp. 887-897 ◽  
Author(s):  
L. C. L. Silveira ◽  
V. H. Perry ◽  
E. S. Yamada
Keyword(s):  
Visual Cortex ◽  
Visual Field ◽  
Ganglion Cell ◽  
Cell Density ◽  
Ganglion Cells ◽  
Amacrine Cells ◽  
Temporal Region ◽  
Cell Distribution ◽  
Area 17 ◽  
Displaced Amacrine Cells

AbstractThe distribution of ganglion cells and displaced amacrine cells was determined in whole-mounted Aotus retinae. In contrast to diurnal simians, Aotus has only a rudimentary fovea. Ganglion cell density decreases towards the periphery at approximately the same rate along all meridians, but is 1.2–1.8 times higher in the nasal periphery when compared to temporal region at the same eccentricities. The total number of ganglion cells varied from 421,500 to 508,700. Ganglion cell density peaked at 15,000/mm2 at 0.25 mm dorsal to the fovea. The displaced amacrine cells have a shallow density gradient, their peak density in the central region is about 1500–2000/mm2 and their total number varied from 315,900 to 482,800. Comparison between ganglion cell density and areal cortical magnification factor for the primary visual cortex, area 17, shows that there is not a simple proportional representation of the ganglion cell distribution. There is an overrepresentation of the central 10 deg of the visual field in the visual cortex. The present results for Aotus and the results of a similar analysis of data from other primates indicate that the overrepresentation of the central visual field is a general feature of the visual system of primates.

Acetylcholine synthesis by displaced amacrine cells

Science ◽  
1980 ◽  
Vol 210 (4468) ◽  
pp. 435-437 ◽  
Author(s):  
S. Hayden ◽  
J. Mills ◽  
R. Masland
Keyword(s):  
Amacrine Cells ◽  
Acetylcholine Synthesis ◽  
Displaced Amacrine Cells

scholarly journals Synaptic Transfer between Rod and Cone Pathways Mediated by AII Amacrine Cells in the Mouse Retina

2018 ◽  
Vol 28 (17) ◽  
pp. 2739-2751.e3 ◽  
Author(s):  
Cole W. Graydon ◽  
Evan E. Lieberman ◽  
Nao Rho ◽  
Kevin L. Briggman ◽  
Joshua H. Singer ◽  
...  
Keyword(s):  
Amacrine Cells ◽  
Mouse Retina ◽  
Aii Amacrine Cells ◽  
Aii Amacrine

scholarly journals Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Thomas A Ray ◽  
Suva Roy ◽  
Christopher Kozlowski ◽  
Jingjing Wang ◽  
Jon Cafaro ◽  
...  
Keyword(s):  
Synapse Formation ◽  
Ganglion Cells ◽  
Plexiform Layer ◽  
Surface Protein ◽  
Amacrine Cells ◽  
Direction Selectivity ◽  
Mouse Retina ◽  
Inner Plexiform Layer ◽  
Starburst Amacrine Cells ◽  
Developing Neurons

A common strategy by which developing neurons locate their synaptic partners is through projections to circuit-specific neuropil sublayers. Once established, sublayers serve as a substrate for selective synapse formation, but how sublayers arise during neurodevelopment remains unknown. Here, we identify the earliest events that initiate formation of the direction-selective circuit in the inner plexiform layer of mouse retina. We demonstrate that radially migrating newborn starburst amacrine cells establish homotypic contacts on arrival at the inner retina. These contacts, mediated by the cell-surface protein MEGF10, trigger neuropil innervation resulting in generation of two sublayers comprising starburst-cell dendrites. This dendritic scaffold then recruits projections from circuit partners. Abolishing MEGF10-mediated contacts profoundly delays and ultimately disrupts sublayer formation, leading to broader direction tuning and weaker direction-selectivity in retinal ganglion cells. Our findings reveal a mechanism by which differentiating neurons transition from migratory to mature morphology, and highlight this mechanism’s importance in forming circuit-specific sublayers.

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