Two types ofDrosophilaR7 photoreceptor cells are arranged randomly: A model for stochastic cell-fate determination

2007 ◽  
Vol 502 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Melanie L. Bell ◽  
James B. Earl ◽  
Steven G. Britt
Keyword(s):  
Cell Fate ◽  
Photoreceptor Cells ◽  
Cell Fate Determination ◽  
Fate Determination

Cell-fate determination in the developing Drosophila eye: role of the rough gene

Development ◽  
1991 ◽  
Vol 112 (3) ◽  
pp. 703-712 ◽  
Author(s):  
U. Heberlein ◽  
M. Mlodzik ◽  
G.M. Rubin
Keyword(s):  
Cell Fate ◽  
Double Mutant ◽  
Homeobox Gene ◽  
Photoreceptor Cells ◽  
Cell Fate Determination ◽  
Cellular Interactions ◽  
Developmental Defects ◽  
Fate Determination ◽  
Drosophila Eye ◽  
Cell Type Specific

The homeobox-gene rough is required in photoreceptor cells R2 and R5 for normal ommatidial assembly in the developing Drosophila eye. We have used several cell-type-specific markers and double mutant combinations to analyze cell-fate determination in rough. We show that the cells that would normally become R2 and/or R5 express a marker, a lacZ insertion in the seven-up (svp) gene, which is indicative of the R1/3/4/6 cell fate. In addition, the analysis of mitotically induced svp, ro double mutant clones in the eye indicates that in rough all outer photoreceptors are under the genetic control of the svp gene. These results show that, in the absence of rough function, R2 and R5 fail to be correctly determined and appear to be transformed into cells of the R3/4/1/6 subtype. This transformation and the subsequent developmental defects do not preclude the recruitment of R7 cells. However, the presence of ommatidia containing more than one R7 and/or R8 cell in rough implies a complex network of cellular interactions underlying cell-fate determination in the Drosophila retina.

scholarly journals DISTAG/TBCCd1 Is Required for Basal Cell Fate Determination in Ectocarpus

2017 ◽  
Vol 29 (12) ◽  
pp. 3102-3122 ◽  
Author(s):  
Olivier Godfroy ◽  
Toshiki Uji ◽  
Chikako Nagasato ◽  
Agnieszka P. Lipinska ◽  
Delphine Scornet ◽  
...  
Keyword(s):  
Cell Fate ◽  
Basal Cell ◽  
Cell Fate Determination ◽  
Fate Determination

scholarly journals The Natural and Engineered 3D Microenvironment as a Regulatory Cue During Stem Cell Fate Determination

2009 ◽  
Vol 15 (3) ◽  
pp. 371-380 ◽  
Author(s):  
Amanda W. Lund ◽  
Bülent Yener ◽  
Jan P. Stegemann ◽  
George E. Plopper
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cell Fate Determination ◽  
Stem Cell Fate ◽  
Fate Determination ◽  
3D Microenvironment
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