Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus

2007 ◽  
Vol 501 (5) ◽  
pp. 691-702 ◽  
Author(s):  
Marie-ève Tremblay ◽  
Mustapha Riad ◽  
David Bouvier ◽  
Keith K. Murai ◽  
Elena B. Pasquale ◽  
...  
Keyword(s):  
Dendritic Spines ◽  
Rat Hippocampus ◽  
Axon Terminals ◽  
Adult Rat

Relational features of acetylcholine, noradrenaline, serotonin and GABA axon terminals in thestratum radiatum of adult rat hippocampus (CA1)

Hippocampus ◽  
1995 ◽  
Vol 5 (6) ◽  
pp. 605-620 ◽  
Author(s):  
Denis Umbriaco ◽  
Sylvia Garcia ◽  
Clermont Beaulieu ◽  
Laurent Descarries
Keyword(s):  
Rat Hippocampus ◽  
Axon Terminals ◽  
Adult Rat

Increase in mRNAs encoding neonatal II and III sodium channel α-isoforms during kainate-induced seizures in adult rat hippocampus

1997 ◽  
Vol 44 (2) ◽  
pp. 179-190 ◽  
Author(s):  
Marguerite Gastaldi ◽  
Fabrice Bartolomei ◽  
Annick Massacrier ◽  
Richard Planells ◽  
Andrée Robaglia-Schlupp ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Rat Hippocampus ◽  
Adult Rat

Dose-related effects of venlafaxine on pCREB and brain-derived neurotrophic factor (BDNF) in the hippocampus of the rat by chronic unpredictable stress

2011 ◽  
Vol 23 (1) ◽  
pp. 20-30 ◽  
Author(s):  
Jing-Jing Li ◽  
Yong-Gui Yuan ◽  
Gang Hou ◽  
Xiang-Rong Zhang
Keyword(s):  
Neurotrophic Factor ◽  
Sucrose Solution ◽  
Brain Derived Neurotrophic Factor ◽  
Rat Hippocampus ◽  
Antidepressant Effect ◽  
High Dose ◽  
Sprague Dawley ◽  
Bdnf Mrna ◽  
Adult Rat ◽  
Element Binding Protein

Background: The molecular pathogenesis of depression and psychopharmacology of antidepressants remain elusive. Recent hypotheses suggest that changes in neurogenesis and plasticity may underlie the aetiology of depression. The hippocampus is affected by depression and shows neuronal remodelling during adulthood.Objective: The present study on the adult rat hippocampus, was to evaluate the dose-related effects of chronic venlafaxine on the expression of brain-derived neurotrophic factor (BDNF) and phosphorylated cyclic-AMP response element binding protein (pCREB).Methods: Sprague-Dawley rats were exposed to a variety of chronic unpredictable stressors (CUSs) to establish a depression model. Rats were treated for either 14 or 28 days with venlafaxine (5 and 10 mg/kg, respectively). The hippocampal expression of pCREB and BDNF mRNA and protein was assessed by using immunohistochemistry, western blotting and reverse transcription polymerase chain reaction (RT-PCR).Results: Rats subjected to CUS procedure consumed less sucrose solution compared with non-stressed rats. The CUS influenced exploratory activity resulting in a reduction of the motility counts. Chronic low dose (5 mg/kg, 14 and 28 days), but not high dose (10 mg/kg, 14 and 28 days) of venlafaxine treatment increased the expression of pCREB and BDNF mRNA and protein in the CUS rat hippocampus.Conclusion: Neuronal plasticity-associated proteins such as pCREB and BDNF play an important role both in stress-related depression and in antidepressant effect.

Liquid diets reduce cell proliferation but not neurogenesis in the adult rat hippocampus

Neuroscience ◽  
2013 ◽  
Vol 254 ◽  
pp. 173-184 ◽  
Author(s):  
A.R. Patten ◽  
D.J. Moller ◽  
J. Graham ◽  
J. Gil-Mohapel ◽  
B.R. Christie
Keyword(s):  
Cell Proliferation ◽  
Rat Hippocampus ◽  
Adult Rat ◽  
Reduce Cell Proliferation
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