Kappa opioid receptors in the rostral ventromedial medulla of male and female rats

2006 ◽  
Vol 500 (3) ◽  
pp. 465-476 ◽  
Author(s):  
Carrie T. Drake ◽  
Andrew X. De Oliveira ◽  
Jonathan A. Harris ◽  
Denise M. Connor ◽  
Clayton W. Winkler ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Female Rats ◽  
Rostral Ventromedial Medulla ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid ◽  
Male And Female ◽  
Male And Female Rats ◽  
Ventromedial Medulla

Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla

Neuroreport ◽  
1998 ◽  
Vol 9 (8) ◽  
pp. 1777-1781 ◽  
Author(s):  
Howard B. Gutstein ◽  
Alfred Mansour ◽  
Stanley J. Watson ◽  
Huda Akil ◽  
Howard L. Fields
Keyword(s):  
Opioid Receptors ◽  
Periaqueductal Gray ◽  
Rostral Ventromedial Medulla ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid ◽  
Ventromedial Medulla

scholarly journals Effects of Kappa Opioid Receptor Agonists on Fentanyl vs. Food Choice in Male and Female Rats: Contingent vs. Non-Contingent Administration

2020 ◽  
Author(s):  
E. Andrew Townsend
Keyword(s):  
Opioid Receptor ◽  
Food Choice ◽  
Food Reinforcement ◽  
Abuse Liability ◽  
Kappa Opioid Receptor ◽  
Female Rats ◽  
Self Administration ◽  
Kappa Opioid ◽  
Male And Female ◽  
Male And Female Rats

AbstractRationaleStrategies are needed to decrease the abuse liability of mu opioid receptor (MOR) agonists. One strategy under consideration is to combine MOR agonists with kappa opioid receptor (KOR) agonists.ObjectivesThe effects of KOR-agonists (U50488, nalfurafine) on fentanyl-versus-food choice were compared under conditions where the KOR agonists were added to the self-administered fentanyl (contingent delivery) or administered as pretreatments (non-contingent delivery) in male and female rats. The effects of increasing and decreasing the magnitude of the alternative food reinforcer were also determined.MethodsRats were trained to respond under a concurrent schedule of fentanyl (0, 0.32-10 μg/kg/infusion) and food reinforcement. In Experiment 1, U50488 and nalfurafine were co-administered with fentanyl as fixed-proportion mixtures (contingent administration). In Experiment 2, U50488 (1-10 mg/kg) and nalfurafine (3.2-32 μg/kg) were administered as acute pretreatments (non-contingent administration). nor-BNI (32 mg/kg) was administered prior to contingent and non-contingent KOR-agonist treatment in Experiment 3. Experiment 4 evaluated the effects of increasing and decreasing the magnitude of the non-drug reinforcer.ResultsBoth U50488 and nalfurafine decreased fentanyl choice when administered contingently, demonstrating that KOR agonists punish opioid choice. Non-contingent U50488 and nalfurafine administration decreased rates of fentanyl and food self-administration without altering fentanyl choice. Both contingent and non-contingent U50488 and nalfurafine effects on fentanyl choice were attenuated by nor-BNI. Fentanyl choice was sensitive to increases and decreases in the magnitude of the non-drug reinforcer.ConclusionsThese results demonstrate that the effects of KOR agonists on fentanyl reinforcement are dependent upon the contingencies under which they are administered.

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