Differential distribution of voltage-gated calcium channel alpha-2 delta (α2δ) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia

2005 ◽  
Vol 491 (3) ◽  
pp. 246-269 ◽  
Author(s):  
Rebecca L. Cole ◽  
Sandra M. Lechner ◽  
Mark E. Williams ◽  
Pat Prodanovich ◽  
Leo Bleicher ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Calcium Channel ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Differential Distribution ◽  
Voltage Gated ◽  
Subunit Mrna ◽  
Α2δ Subunit ◽  
Voltage Gated Calcium Channel

P/Q-type voltage-gated calcium channel antibodies in paraneoplastic disorders of the central nervous system

1999 ◽  
Vol 22 (1) ◽  
pp. 119-122 ◽  
Author(s):  
Raymond Voltz ◽  
Antoine F. Carpentier ◽  
Myrna R. Rosenfeld ◽  
Jerome B. Posner ◽  
Josep Dalmau
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Calcium Channel ◽  
Voltage Gated ◽  
The Central Nervous System ◽  
Voltage Gated Calcium Channel

Distribution of neurons expressing α1G subunit mRNA of T-type voltage-dependent calcium channel in adult rat central nervous system

1999 ◽  
Vol 268 (2) ◽  
pp. 77-80 ◽  
Author(s):  
Masahiko Kase ◽  
Shingo Kakimoto ◽  
Satoru Sakuma ◽  
Takeshi Houtani ◽  
Hitoshi Ohishi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Calcium Channel ◽  
Adult Rat ◽  
Subunit Mrna ◽  
Voltage Dependent Calcium Channel ◽  
Voltage Dependent

Su1934 Activation Status of the Central Nervous System and Lumbar Dorsal Root Ganglia in a Mouse Model of Polymicrobial Abdominal Septic Ileus

2016 ◽  
Vol 150 (4) ◽  
pp. S592-S593
Author(s):  
Sara Nullens ◽  
Steven Deleye ◽  
Joris De Man ◽  
Sven M. Francque ◽  
Steven Staelens ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mouse Model ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
The Central Nervous System ◽  
Activation Status

scholarly journals straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel α1 subunit

2008 ◽  
Vol 181 (1) ◽  
pp. 157-170 ◽  
Author(s):  
Cindy V. Ly ◽  
Chi-Kuang Yao ◽  
Patrik Verstreken ◽  
Tomoko Ohyama ◽  
Hugo J. Bellen
Keyword(s):  
Calcium Channel ◽  
Neuronal Excitability ◽  
Neuromuscular Junctions ◽  
Synaptic Function ◽  
Voltage Gated ◽  
Α2δ Subunit ◽  
Voltage Gated Calcium Channel ◽  
Α1 Subunit ◽  
Synaptic Level ◽  
Synaptic Stabilization

In a screen to identify genes involved in synaptic function, we isolated mutations in Drosophila melanogaster straightjacket (stj), an α2δ subunit of the voltage-gated calcium channel. stj mutant photoreceptors develop normal synaptic connections but display reduced “on–off” transients in electroretinogram recordings, indicating a failure to evoke postsynaptic responses and, thus, a defect in neurotransmission. stj is expressed in neurons but excluded from glia. Mutants exhibit endogenous seizure-like activity, indicating altered neuronal excitability. However, at the synaptic level, stj larval neuromuscular junctions exhibit approximately fourfold reduction in synaptic release compared with controls stemming from a reduced release probability at these synapses. These defects likely stem from destabilization of Cacophony (Cac), the primary presynaptic α1 subunit in D. melanogaster. Interestingly, neuronal overexpression of cac partially rescues the viability and physiological defects in stj mutants, indicating a role for the α2δ Ca2+ channel subunit in mediating the proper localization of an α1 subunit at synapses.

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