Drosophila neuroblast 7-3 cell lineage: A model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of ganglion mother cell identity

2004 ◽  
Vol 481 (3) ◽  
pp. 240-251 ◽  
Author(s):  
Rachel Karcavich ◽  
Chris Q. Doe
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mother Cell ◽  
Cell Lineage ◽  
Model System ◽  
Cell Identity ◽  
Ganglion Mother Cell

scholarly journals Developmental Coordination of Gamete Differentiation with Programmed Cell Death in Sporulating Yeast

2015 ◽  
Vol 14 (9) ◽  
pp. 858-867 ◽  
Author(s):  
Michael D. Eastwood ◽  
Marc D. Meneghini
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mother Cell ◽  
Developmental Stages ◽  
Parental Cell ◽  
Alternative Form ◽  
Content Type ◽  
Bona Fide ◽  
Mother Cells ◽  
Degree Of Differentiation

ABSTRACT The gametogenesis program of the budding yeast Saccharomyces cerevisiae , also known as sporulation, employs unusual internal meiotic divisions, after which all four meiotic products differentiate within the parental cell. We showed previously that sporulation is typically accompanied by the destruction of discarded immature meiotic products through their exposure to proteases released from the mother cell vacuole, which undergoes an apparent programmed rupture. Here we demonstrate that vacuolar rupture contributes to de facto programmed cell death (PCD) of the meiotic mother cell itself. Meiotic mother cell PCD is accompanied by an accumulation of depolarized mitochondria, organelle swelling, altered plasma membrane characteristics, and cytoplasmic clearance. To ensure that the gametes survive the destructive consequences of developing within a cell that is executing PCD, we hypothesized that PCD is restrained from occurring until spores have attained a threshold degree of differentiation. Consistent with this hypothesis, gene deletions that perturb all but the most terminal postmeiotic spore developmental stages are associated with altered PCD. In these mutants, meiotic mother cells exhibit a delay in vacuolar rupture and then appear to undergo an alternative form of PCD associated with catastrophic consequences for the underdeveloped spores. Our findings reveal yeast sporulation as a context of bona fide PCD that is developmentally coordinated with gamete differentiation.

Cell death in normal and rough eye mutants of Drosophila

Development ◽  
1991 ◽  
Vol 113 (3) ◽  
pp. 825-839 ◽  
Author(s):  
T. Wolff ◽  
D.F. Ready
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Compound Eye ◽  
Cell Lineage ◽  
Cell Fates ◽  
Cone Cells ◽  
A Cell ◽  
Retinal Epithelium ◽  
Fly Eye ◽  
Dying Cells

The regular, reiterated cellular pattern of the Drosophila compound eye makes it a sensitive amplifier of defects in cell death. Quantitative and histological methods reveal a phase of cell death between 35 and 50 h of development which removes between 2 and 3 surplus cells per ommatidium. The timing of this epoch is consistent with cell death as the last fate to be specified in the progressive sequence of cell fates that build the ommatidium. An ultrastructural survey of cell death suggests dying cells in the fly eye have similarities as well as differences with standard descriptions of programmed cell death. A failure of cell death to remove surplus cells disorganizes the retinal lattice. A screen of rough eye mutants identifies two genes, roughest and echinus, required for the normal elimination of cells from the retinal epithelium. The use of an enhancer trap as a cell lineage marker shows that the cone cells, like other retinal cells, are not clonally related to each other or to their neighbors.

scholarly journals Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila

2002 ◽  
Vol 9 (2) ◽  
pp. 59-69 ◽  
Author(s):  
S. Gorski ◽  
M. Marra
Keyword(s):  
Cell Death ◽  
Drosophila Melanogaster ◽  
Programmed Cell Death ◽  
Gene Discovery ◽  
Fruit Fly ◽  
Model System ◽  
Physiological Process ◽  
Wide Spread ◽  
Cell Death Gene ◽  
Genetics And Genomics

Programmed cell death (PCD) is an essential and wide-spread physiological process that results in the elimination of cells. Genes required to carry out this process have been identified, and many of these remain the subjects of intense investigation. Here, we describe PCD, its functions, and some of the consequences when it goes awry. We review PCD in the model system, the fruit fly, Drosophila melanogaster, with a particular emphasis on cell death gene discovery resulting from both genetics and genomics-based approaches.

scholarly journals Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary*

Endocrinology ◽  
2001 ◽  
Vol 142 (6) ◽  
pp. 2468-2480 ◽  
Author(s):  
Tiina Matikainen ◽  
Gloria I. Perez ◽  
Timothy S. Zheng ◽  
Thomas R. Kluzak ◽  
Bo R. Rueda ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Caspase 3 ◽  
Gene Knockout ◽  
Cell Lineage ◽  
Lineage Specificity ◽  
Cell Death Signaling

scholarly journals The embryonic cell lineage of the nematode Halicephalobus gingivalis (Nematoda: Cephalobina: Panagrolaimoidea)

Nematology ◽  
2007 ◽  
Vol 9 (4) ◽  
pp. 573-584 ◽  
Author(s):  
Wouter Houthoofd ◽  
Gaëtan Borgonie
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Cell Lineage ◽  
Model Organism ◽  
Embryonic Cell ◽  
Somatic Muscle ◽  
Cell Specification ◽  
C Elegans ◽  
Fast Development ◽  
Halicephalobus Gingivalis

AbstractThis paper describes the nearly complete embryonic cell lineage of the terrestrial nematode, Halicephalobus gingivalis, up to somatic muscle contraction, resulting in the formation of 536 cells, of which 24 undergo programmed cell death. Halicephalobus gingivalis has a 94% lineage homology with both Caenorhabditis elegans and Pellioditis marina, and a fate homology of only 86% and 78%, respectively. Although H. gingivalis belongs to a different superfamily than C. elegans and P. marina, its cell lineage is remarkably consistent with them. Variations in the fate distribution of cells among the different species were only observed at the end of the cell lineage. The data presented here show that the polyclonal cell specification is much more widespread in clades 9 and 10 and is not a highly derived trait that is specifically linked to the fast development of the model organism C. elegans.

Sporulation-associated Mother Cell Lysis in Bacillus Displays Markers of Programmed Cell Death

2015 ◽  
Vol 109 (7) ◽  
pp. 1283 ◽  
Author(s):  
Swati V. Roy ◽  
Sachin N. Hajare ◽  
Satyendra Gautam ◽  
Deepti Deobagkar ◽  
Arun Sharma
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mother Cell ◽  
Cell Lysis
Sign in / Sign up

Export Citation Format

Share Document