Development of cholinergic terminals around rat spinal motor neurons and their potential relationship to developmental cell death

2001 ◽  
Vol 435 (2) ◽  
pp. 171-183 ◽  
Author(s):  
Richard Wetts ◽  
James E. Vaughn
Keyword(s):  
Cell Death ◽  
Motor Neurons ◽  
Spinal Motor Neurons ◽  
Spinal Motor ◽  
Potential Relationship ◽  
Developmental Cell Death ◽  
Cholinergic Terminals

Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

Nature ◽  
1992 ◽  
Vol 360 (6406) ◽  
pp. 753-755 ◽  
Author(s):  
Qiao Yan ◽  
Jeffrey Elliott ◽  
William D. Snider
Keyword(s):  
Cell Death ◽  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Spinal Motor Neurons ◽  
Spinal Motor

The zebrafish detour gene is essential for cranial but not spinal motor neuron induction

Development ◽  
1999 ◽  
Vol 126 (12) ◽  
pp. 2727-2737 ◽  
Author(s):  
A. Chandrasekhar ◽  
H.E. Schauerte ◽  
P. Haffter ◽  
J.Y. Kuwada
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Spinal Motor Neuron ◽  
Neuronal Phenotype ◽  
Spinal Motor Neurons ◽  
Spinal Motor ◽  
Hh Signaling ◽  
Function Cell

The zebrafish detour (dtr) mutation generates a novel neuronal phenotype. In dtr mutants, most cranial motor neurons, especially the branchiomotor, are missing. However, spinal motor neurons are generated normally. The loss of cranial motor neurons is not due to aberrant hindbrain patterning, failure of neurogenesis, increased cell death or absence of hh expression. Furthermore, activation of the Hh pathway, which normally induces branchiomotor neurons, fails to induce motor neurons in the dtr hindbrain. Despite this, not all Hh-mediated regulation of hindbrain development is abolished since the regulation of a neural gene by Hh is intact in the dtr hindbrain. Finally, dtr can function cell autonomously to induce branchiomotor neurons. These results suggest that detour encodes a component of the Hh signaling pathway that is essential for the induction of motor neurons in the hindbrain but not in the spinal cord and that dtr function is required for the induction of only a subset of Hh-mediated events in the hindbrain.

scholarly journals Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS

iScience ◽  
2021 ◽  
pp. 102700
Author(s):  
Jennifer L. Shadrach ◽  
Wesley M. Stansberry ◽  
Allison M. Milen ◽  
Rachel E. Ives ◽  
Elizabeth A. Fogarty ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Spinal Motor Neurons ◽  
Spinal Motor

A new method of isolating spinal motor neurons from fetal mouse

2017 ◽  
Vol 288 ◽  
pp. 57-61 ◽  
Author(s):  
Weifang Wang ◽  
Bao Qi ◽  
Hui Lv ◽  
Fei Wu ◽  
Lulu Liu ◽  
...  
Keyword(s):  
Motor Neurons ◽  
New Method ◽  
Fetal Mouse ◽  
Spinal Motor Neurons ◽  
Spinal Motor
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